base editing

From base editing to RNA editing (3)

Summary: Claims about spontaneous deamination fail to link energy-dependent changes from base editing to RNA-mediated DNA repair of damage caused by the virus-driven degradation of messenger RNA. Highly efficient RNA-guided base editing in mouse embryos 27 February 2017 They reported the use of RNA-programmable deaminases to make various animal models with single amino-acid substitutions.They linked the single amino acid substitutions from the correction of nonsense mutations in the future to the correction of genetic defects in human embryos. Reported as:…

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From base editing to RNA editing (2)

Summary: The link from the creation of the sun’s anti-entropic virucidal energy and the physiology of pheromone-controlled reproduction to fixation of RNA-mediated amino acid substitutions in the organized genomes of all living genera is all that is required to claim adaptation for comparison to Koonin’s moronic assertion that the amino acid composition of proteins varies because the composition evolved. Digital reconstruction of the Ceprano calvarium (Italy), and implications for its interpretation A “fresh” (i.e., not yet “fossil”) bone can be…

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From base editing to RNA editing

Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine “Nature conveniently provides us with cytosine deaminase enzymes that operate on DNA,” Liu tells The Scientist. The creation of quantized energy in sunlight links energy as information from electrons to ecosystems via the physiology of reproduction in all living genera. The claim that “Nature” provides us with cytosine deaminase enzymes makes it seem that the enzymes emerged and automagically evolved to become purposeful and meaningful in the context of ridiculous theories…

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Criticisms of a validated model

Microglia Turnover in the Human Brain “With electron microscopy, we find a variety of immune cells in the brain, especially in contexts of disease,” she writes. Richard Feynman predicted this in the context of a lecture on nanotechnology. He presciently placed cryo-EM into the context of a lecture about Plenty of Room at the Bottom. Examination at this level of observable energy-dependent top-down causation has since linked the sun’s anti-entropic virucidal energy from hydrogen-atom transfer in DNA base pairs in…

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Thanks again for asking about DNA methylation

Re: RNA-directed DNA methylation (1996) See: From Fertilization to Adult Sexual Behavior Molecular epigenetics. It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes. See also: RNA-directed DNA methylation: an epigenetic…

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Viral infection linked to cancer via a “unique mechanism”

Summary: The virus-driven degradation of messenger RNA was reported in the context of a “unique mechnanism.” DNA cytidine deaminases remove RNA-mediated amino acid substitutions from a cytosine and convert the cytosine uracil. The deamination causes the degradation of DNA and mutations if not repaired. Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression The family members of apolipoprotein B messenger RNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3; A3) are DNA cytidine deaminases that remove the amino group from a…

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Epitranscriptomics: a “new” field

Conclusion: Serious scientists have a 20 year history of their ability to link energy-dependent changes from electrons to ecosystems via the physiology of pheromone-controlled reproduction in the context of hydrogen-atom transfer in DNA base pairs in solution. This fact links hydrogen-atom transfer in DNA base pairs in solution to the fixation of RNA-mediated amino acid substitutions in hydrophobic supercoiled DNA, which protects all organized genomes from virus-driven entropy. I reiterate: Hordenine lacks a meta-hydroxyl group compared to dopamine, rendering it…

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For God and Country

Dispelling the ignorance of theorists

American Legion Riders (Riding for God and Country on 9/9/17) Summary: The highest-order of energy-dependent pre-assembly of respiratory chain complexes allows mitochondria to respond to energy-requiring conditions. There is no such thing as the emergence of energy, self-assembly, self-organization or any other pseudoscientific nonsense touted by theorists. Their theories exemplify what Richard P. Feynman referred to as “human idiocy.” That is why I refer to theorists who argue with me as “biologically uninformed science idiots.” Friends sometimes tell me I…

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Host-derived creation of all pathology (2 of 2)

Summary: All serious scientists know that all epigenetic diversity is food energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction. See for comparison: Jay R. Feierman: “Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.” A Bacterial Messenger Molecule Extends Healthspan …indole,…

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Evolutionary congruence (losers) vs ecological adaptation (winners)

Nuclear and Plastid DNA Sequence-based Molecular Phylogeography of Salvadora oleoides (Salvadoraceae) in Punjab, India Reveals Allopatric Speciation in Anthropogenic Islands Due to Agricultural Expansion This is the first DNA-sequence based phylogeographic assessment of Salvadora in the world. Sequence based phylogeographic assessment of tropical tree species is a relative rarity and in India, such investigations are almost non-existent.   Kalevi Kull: Censorship & Royal Society Evo Event Nobody wants to belong to the party of losers. One of the best strategies…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]