biophotonics

RNA-mediated silencing (2)

March 14, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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Transcriptional and post-transcriptional control of epithelial-mesenchymal plasticity: why so many regulators? 3/12/22 God’s Creation of sunlight and humidity at the origin of life ~6000 years ago links light-activated carbon fixation in cyanobacteria to microRNA-mediated protein folding chemistry and healthy longevity across kingdoms via the number of regulators. Fixation of amino acid substitutions is the link to viral endemicity. The facts are clear in: Cellulose: A Plant Cell Biology Game , a STEM toy for ages 14+, which links God’s Creation…

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RNA-mediated silencing (1)

March 12, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, What's in the News
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The alphavirus 3′-nontranslated region: size heterogeneity and arrangement of repeated sequence elements 1/5/98 The 19-nt conserved sequence element directly adjacent to the poly(A) tract was found in all viruses, More than 1000 indexed publications that mention microRNAs, which are small RNAs, have been added each month during the past 6 years. That makes it almost impossible to keep up with “origin of life” Science. WHO doesn’t help. Where’s Fauci? Systemic Silencing Of An Endogenous Plant Gene By Two Classes Of…

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Photonics in Forensics (9)

March 11, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, replication timing, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity, Variations
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Suppression and Activation of Intracellular Immune Response in Initial Severe Acute Respiratory Syndrome Coronavirus 2 Infection 11/26/21 …when intracellular immunity is suppressed, SARS-CoV-2 shows a correlation with dysregulation of metal ion homeostasis. Herein, the inhibitory activity of copper ions against SARS-CoV-2 was further validated in in vitro experiments. Ions are atoms that have a positive or negative charge because they have unequal numbers of protons and electrons. If atoms lose electrons, they become positive ions, or cations. If atoms gain…

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Photonics in Forensics (7)

March 10, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Living with the Neanderthals 8/14/03 …Bear pleads for biologists to write clearly: “Don’t they realize how important it is to get the word out to everybody?” Social media censorship prevents people from learning the facts. All intelligent serious scientists and many intelligent people know that sunlight is beneficial in the context of biophotonics and forensics In the context of coronavirus pathology, this was stated clearly as US government experiments with simulations to show the coronavirus can ‘quickly’ be destroyed by…

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Photonics in Forensics (6)

March 4, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic
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The alphavirus 3′-nontranslated region: size heterogeneity and arrangement of repeated sequence elements 1/5/98 The 19-nt conserved sequence element directly adjacent to the poly(A) tract was found in all viruses The 19-nt conserved sequence element is biophysically constrained across kingdoms. No experimental evidence of top-down energy-dependent causation suggests that this 19-nt conserved sequence evolved via natural selection for mutations during billions to millions of years. For comparison, the conservation of one 22-nucleotide ring was reported in Footprints of a Singular 22-Nucleotide…

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Photonics in Forensics (5)

March 1, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Forensics: a laboratory or department responsible for tests used in detection of crime, especially the crimes committed by corrupt politicians. Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability 1/5/21 However, the strength of this mechanism during embryogenesis, as well as its relationship with other known regulatory elements, such as microRNA, remains unclear. God’s Creation of sunlight and humidity biophysically constrains the pH-dependent crosstalk via oxidative phosphorylation and stem cell creation. That fact about microRNAs is perfectly clear. See:…

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Peptide synthesis and therapy update 2/28/22

February 28, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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I just discovered the URL I used for Peptide synthesis at the origin of life has changed from what I initially reported in more than 100 different blog posts. That could make it more difficult for most people to link peptide synthesis to the origin of information and to peptide therapy via Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20, which was published two days after former President Trump linked God’s Creation of sunlight and…

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Photonics in Forensics (4)

February 24, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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See first: Photonics in Forensics (3) MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position 2/22/22 ….the two 3′-binding modes both appear to be compatible with either of the two gene-regulatory  processes that involve 3′ pairing—TDMD (target-directed miRNA degradation (TDMD) and miRNA-mediated repression. All metabolic disease processes are microRNA-mediated see: microRNA 136,017 results and this 2/23/22 indexed adddition:”Spatially Resolved, Error-Robust Multiplexed MicroRNA Profiling in Single Living Cells” 2/22/22 The FluoELs enabled a single-cell…

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Photonics in Forensics (3)

February 23, 2022
James Kohl
Adaptations, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Model Organisms, Physics, replication timing, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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On 2/22/22, I was able to reach many more stupid theorists than usual with one tweet, which was based on publication of: MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position 2/22/22 ….the two 3′-binding modes both appear to be compatible with either of the two gene-regulatory processes that involve 3′ pairing—TDMD (target-directed miRNA degradation (TDMD) and miRNA-mediated repression. In my model, all gene regulatory processes are energy-dependent and “MicroRNAs organize intrinsic variation…

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