Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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Natural models inspire future therapeutics

Natural models inspire future therapeutics See: Screaming viruses and Alzheimer’s (1) Screaming viruses and Cancer Screaming Viruses and Alzheimer’s (2) MicroRNA biogenesis, the microRNAome, and your brainome and Reciprocal Interactions Between Gut Microbiota and Host Social Behavior We suggest that investigating these reciprocal interactions can advance our understanding of sociality, from healthy and impaired social cognition to the evolution of specific social behaviours and societal structure. There is no natural model of evolved social behavior. I suggest that all theorists…

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NHEJ disruption and HDR correction?

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop is being held in Park Inn by Radisson Pulkovskaya Hotel & Conference Centre St Petersburg, Saint-Petersburg, Russia, September 2-7 2018. We will discuss all aspects…

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An evolutionary theory killer

Cardiac energy metabolism requires units of energy

Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism (First published May 17, 2018 ) Silencing the mRNA of general control of amino acid synthesis 5-like protein 1 reduced acetylation of LCAD and βHAD as well as fatty acid oxidation rates in cardiomyocytes. Thus, hypertrophy in CHDs prevents the postnatal increase in myocardial acetylation, resulting in a delayed maturation of cardiac fatty acid oxidation. The virus-driven theft of quantized energy causes the silencing of mRNA, which generally controls amino…

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Predicting naturally occurring viral latency

KLRD1-expressing natural killer cells predict influenza susceptibility We identified KLRD1-expressing NK cells as a potential biomarker for influenza susceptibility. Expression of KLRD1 was inversely correlated with symptom severity. Our results support a model where an early response by KLRD1-expressing NK cells may control influenza infection. The NK cells are natural killer cells that help to control viral latency This was reported as: Scientists discover biomarker for flu susceptibility  “We found that a type of immune cell called a natural killer…

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An evolutionary theory killer

Quantum initiation of cold chemistry vs Hypeology (1)

Cold chemistry with two atoms Summary For centuries, chemists have written equations representing chemical reactions by using symbols for atoms and molecules; for example, 2H2O + 2Na → 2NaOH + H2. This short notation shows only four reacting particles, but even in a classroom demonstration where a small piece of sodium is dropped in water, the total number of reactants will be on the order of Avogadro’s number (∼6 × 1023). On page 900 of this issue, Liu et al.…

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Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

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The concept of a species (4)

Trump Tries to Destroy the West The alliance between the United States and Western Europe has accomplished great things. It won two world wars in the first half of the 20th century. Then it expanded to include its former enemies and went on to win the Cold War, help spread democracy and build the highest living standards the world has ever known. President Trump is trying to destroy that alliance. —– Scientific creationists from South Korea, the “creationist capitol of…

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The concept of a species (2)

The science of peaceful coexistence among members of the same species and human populations that are vilified starts with an understanding of the birds and the bees, which seems to be beyond the ability of neo-Darwinian theorists and Big Bang cosmologists to grasp. See for comparison: Birds from different species recognize each other and cooperate Article excerpt 1): Australian fairy-wrens not only recognize individual birds from other species, but also form long-term partnerships that help them forage and defend their…

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An evolutionary theory killer

The concept of a species (3)

Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction (2005) This remodeling of LH circuitry could contribute to the chronic deficit in reward function that has been hypothesized to drive the transition to drug addiction. Lena D. van der Stap discussed her role in the publication of this article, which failed to make any assumptions about mutations and/or evolution. James Kohl Did you co-author Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction McEwen told…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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