What energy source do proteins prefer?

Quantized energy as information is the anti-entropic virucidal source of healthy longevity. All pathology is caused by virus-driven energy theft. Impact of cytosine methylation on DNA binding specificities of human transcription factors …many developmentally important proteins display preference for mCpG-containing sequences.   How do proteins display a preference for anything except food and codon optimality? Natural selection for quantized food energy-dependent codon optimality links the structure and function of supercoiled DNA to protection from virus-driven energy theft. That fact was…

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The death of human ethology via ecology

Nutrient-dependent/pheromone-controlled adaptive evolution: a model Open access publication on June 14, 2013 Mutation-driven evolution also published on June 14, 2013 Variable habitat conditions drive species covariation in the human microbiota http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005435 Open access publication on April 27, 2017 Conclusion: …we found that genetically related species respond to fluctuating habitat conditions in the same way, implying that they occupy similar ecological niches. Thus, current taxonomic groupings of bacteria are largely sufficient for explaining cross-sectional correlations in relative species abundances over the…

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Dispensing with March for Science Dispatches (2)

Dispensing with March for Science Dispatches (1) “We want to work with other science societies to start preparing their members—the scientists and the friends of science—to communicate what needs to be communicated,” he told The Scientist. See: Cytosis: A Cell Biology Board Game A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses! 6,650 backers pledged $389,357 to help bring this project to life. More than 60,000 published…

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Dispensing with March for Science Dispatches (1)

Earlier today, Phillip from ATT repaired the splicings that were required to re-establish my energy-dependent internet access. I published 1000 posts to this blog before the April 22, 2017 March for Science. Most of the blog posts attest to the facts about energy-dependent alternative splicings of RNA that link chirality and autophagy to all biodiversity on Earth via the physiology of pheromone-controlled reproduction. See for comparison: March for Science: Dispatches from Washington, DC “The hope is somebody will listen. We’re…

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Game over for theorists

Trump’s opacity with regard to his positions on science has propelled science advocacy to a new level of intensity. Marching Into an Uncertain Future If you saw what he did with the leaks and ‘fake news,’ why can’t you see what he has done with the controlled release of information. He got two conflicting representations of energy-dependent top-down causation concurrently published in Science. 1) Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention 2) A conserved NAD+ binding pocket…

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Open Science: Closed to facts about microRNAs

See my 5-part series on: The tipping point? 50, 000 publications Imagine how we could accelerate innovation, stimulate economic growth and all the solutions we need to live on a healthy and sustainable planet, if we were to open up our science fully and allow a free flow of scientific knowledge.” says Kamila Markram, a neuroscientist and the CEO of Frontiers, one of the largest Open Access science publishers in the world and a leader in the Open Science movement.…

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What is life without sunshine?

Summary: It seems likely that Schrodinger’s anti-entropic virucidal effect of sunlight will be linked to the RNA-mediated de novo creation of all organized genomes and the maintenance of the “spotless epigenome” in this presentation later today. If so, even theorists and other pseudoscientists who planned to “March for Science” will finally be seen in the context of Dobzhansky’s claims about the “…light of evolution.” Erasing Epigenetic Marks: Eternal Sunshine of the Spotless Epigenome Topics to be covered: The variety of…

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Viruses in pathogenic variants disrupt alternative splicings (2)

Autophagy is activated by virus-driven energy theft. Click on the term “Autophagy” That fact is clear in the diagram of systems complexity and in my model. See for contrast:  Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors A key question in virology, that is potentially answerable using paleovirological analyses, is what caused the elimination of extinct viral lineages? Conclusion: The selection pressures acting on hsaHTenv, its orthologs and progenitors might have been complex. Loss of fusogenicity…

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Viruses in pathogenic variants disrupt alternative splicings

Pathogenic variants that alter protein code often disrupt splicing Approximately 10% of exonic mutations altered splicing, mostly by disrupting multiple stages of spliceosome assembly. We present a large-scale characterization of exonic splicing mutations using a new technology that facilitates variant classification and keeps pace with variant discovery. Assay of nearly 5,000 mutations reveals roots of genetic splicing errors “Splicing errors can be very deleterious because instead of just changing one amino acid [the building block of a protein], it can…

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Respiration-dependent endogenous RNA interference

If you are a theorist, please take a deep breath before beginning to read this. The speed of light on contact with water has been linked from the level of oxygen on Earth to all biodiversity via the physiology of pheromone-controlled reproduction and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in all living genera. @jvkohl 15h15 hours ago  It’s “game over” for all theorists. There’s a new game in town. https://www.kicktraq.com/projects/geniusgames/cytosis-a-cell-biology-board-game/ … It’s an evolutionary theory killer. @jvkohl…

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