Diseases & Disorders

UV light, H2O, and epigenetic effects… (3)

Trump nominates conservative Amy Coney Barrett for Supreme Court She would be the only justice on the current court not to have received her law degree from an Ivy League school. The eight current justices all attended either Harvard or Yale. Most researchers at Harvard and Yale failed to admit, and failed to teach their students, that God’s Creation of UV light and water biophysically constrains viral latency across kingdoms via oxidative phosphorylation. They are being forced to tell the…

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UV light, H2O, and epigenetic effects… (1)

See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective,…

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Coherently organized healthy longevity (3)

  Development of MicroRNAs as Potential Therapeutics against Cancer 7/15/20 The perfect pairing of the miRNA with the target mRNA promotes mRNA degradation, while imperfect base pairing will lead to protein translational repression. God’s UV light-activated “Perfect Pairing” prevents cancer and all other forms of virus-driven pathology. See: Light-mediated strong coupling between a mechanical oscillator and atomic spins 1 meter apart 5/10/20 To achieve quantum-coherent coupling (40), g must also exceed all thermal and quantum back-action decoherence rates. This is…

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The microRNA-mediated fight against COVID-19 (1)

History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

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Coherently organized healthy longevity (1)

A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

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pH-dependent healthy longevity (2)

Trump wears mask while visiting wounded soldiers, medical workers at Walter Reed hospital 7/12/20 Trump said he planned to wear a mask during the Walter Reed visit because “you’re in a hospital setting,” and “I think it’s a very appropriate thing. … I have no problem with a mask.” Use of a fast transcutaneous CO2 detector to evaluate escape hoods: the “CAPS 2000” with the inlet valves removed from the nose-cup as a test case (2012) Research showed increased CO2/hypercapnia…

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pH-dependent healthy longevity (1)

Who else linked pH-dependent viral latency to pH-dependent healthy longevity via the Korean Genome Project‘s ethnicity-specific reference genome sequences? The facts about energy-dependent microRNA-mediated biophysically constrained viral latency can be compared to ridiculous theories from the gene-centric Human Genome Project touted by NIH Director, Francis S. Collins. Other neo-Darwinian theorists also failed to start with facts about God’s Creation of UV light and water, which Charles Darwin included in his energy-dependent “conditions of life” Darwin’s “conditions of life” presciently linked…

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pH-dependent viral latency (7)

Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots  6/12/20 …we demonstrate that the RNA mutation-based APOBEC3A assay is applicable to clinical samples from cancer patients. Our study presents a strategy to follow the dysregulation of APOBEC3A in tumors, providing opportunities to investigate the role of APOBEC3A in tumor evolution… Reported as: Monitoring RNA hotspots reveals target in cancer tumor cells by University of California, Irvine The targeting is microRNA-mediated. Proteins do not create themselves…

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pH-dependent viral latency (6)

See first: pH-dependent viral latency (5) Researchers from Iran linked light-activated microRNA biogenesis in plants to the expression genes that effect the number, size and/or the pH of pathways that influence melanin synthesis in the context of human iris color and human skin pigmentation via the L‐tyrosine amino acid precursor. The claim on 6/5/20 by Frank M. LaFerla about the links from energy-dependent changes in microbes to humans and racism was retracted on the same day. Thank God, scientific Creationists…

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NIH’s ignorance: from roots to shoots (1)

A plant’s diet, surviving in a variable nutrient environment 3/3/20 links Algal ancestor of land plants was preadapted for symbiosis 10/5/15 from our NIH Director’s ridiculous claims about evolution across billions to millions of years to the fact that George M. Church has abandoned all hope for scientific progress that might otherwise have been achieved from follow-up on the Human Genome Project. See: Korean Genome Project: 1094 Korean personal genomes with clinical information 5/27/20 (with co-author George Church -Department of Genetics,…

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