Diseases & Disorders

The biologically-based origin of the mammalian placenta (2)

See also: The biologically-based origin of the mammalian placenta I’ll preface this follow-up on the origins of the mammalian placenta with comments that attest to foolishness of theoretical physicists who try to link Big Bang cosmology to neo-Darwinian theories about mutations and evolution. RPF Interviews Dr. Alexander Unzicker Excerpt 1)  “It annoys me too much to see another generation of physicists deterred by the dumb messy patchwork called the standard model of particle physics, that hides the basic problems physics…

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Are viruses microRNAs?

Evolution of Intelligent Viruses and Jumping Genes Conclusion: “…it is intelligent warfare between mobile genetic elements and the epigenetic responses of the cell that, most likely, determines evolution.” My comment: This conclusion appears to place biologically-based cause and effect into the context of viruses and evolved immune system responses. Epigenetically-effected immune system responses can be compared in the context of epigenetic effects on cell type differentiation that link ecological variation to ecological adaptation. This puts cause and effect into their…

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Mute points: most are afraid to mention them

In discussion of anthropic theory and the fact that fundamental physical constraints underlie our life-enabling universe, Andrew Jones wrote: “Pathogenicity of E. coli 0157 has nothing to do with its temperature stability.” Like others who are biologically uninformed, Jones defies a common sense approach and he also defies the US president’s call for intelligent researchers to be integrated into areas of medical research: See: Obama Calls for Medical-Research Expansion Excerpt: “President Barack Obama called for a new medical research push…

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Amino acid homeostasis for a Happy New Year!

Works by Christ et al., continue to attest to the rejuvenating power of blood. For example, in the context of epigenetic pharmacology and regenerative medicine, one protein in the blood has been linked to health via nutrient-dependent amino acid substitutions that differentiate all cell types in all individuals of all species. Simply put, blood seems to reverse aging in another mammal, which suggests an across-species link to RNA-mediated amino acid substitutions. For contrast, nothing currently known about any species links…

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Unified nutritional and molecular mechanisms

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits Article image: Excerpt: “…unifying nutritional and molecular mechanisms remain elusive.” Reported as Molecular mechanism behind health benefits of dietary restriction identified Excerpt 1) “Dietary restriction is a type of intervention that can include reduced overall food intake, decreased consumption of particular macronutrients such as protein, or intermittent bouts of fasting. It is known to have beneficial health effects, including protection from tissue injury and improved metabolism. It has also been…

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Chemical ecology and RNA-mediated control of DNA loops

DNA Loop-the-Loops A new full-genome map indicates how DNA is folded within the nuclei of human cells.By Kate Yandell | December 11, 2014 Excerpt: “…many loops were conserved among cell types, and even between mice and humans. But others seemed to drive cell type-specific gene expression patterns.” My comment to The Scientist Magazine: Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Excerpt: “A form of GnRH associated with sexual orientation in yeasts links control of the feedback loops and developmental processes required for…

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Single-cell level assay of protein biosynthesis and degradation

High-throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry Excerpt: “We use this technique to show modulation of a microRNA critical for T-cell function, miR-155. We adapt this assay for simultaneous detection of mRNA and proteins by ImageStream technology.” Reported as: Technology breakthrough reveals cellular transcription process My comment: Their assay simultaneously detects epigenetically-effected changes in the miRNA/mRNA balance and proteins, which link nutrient-uptake to the physical landscape of DNA in the organized genomes of…

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Glycine and GnRH: Am I being pedantic?

Posted to the FB page on 12/3/14 at Skeptics; Atheists; Realists; Agnostics; Humanists Stephen Hawking and Brian Cox take part in Monty Python sketch – video Excerpt: “I think you are being pedantic.” My comment: Some people may think I am being pedantic. My focus is not on physics; it is on the role of GnRH in cell type differentiation. My focus now extends from what is known about quantum physics, quantum smell, chirality, quantum biology, and quantum consciousness. What is known about chirality…

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Dual genomes: exposing the evolution industry

Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes Excerpt: “The CDP showed a significant overrepresentation of certain gene ontology (GO) groups (global tests Po0.001–0.009), using the programme FUNC23 (Methods). These groups included GPCRs, in particular olfactory receptors (ORs), and other membrane and cell-surface proteins, as well as proteins related to the immune system, such as the MHC (Class I and II), and drug metabolism…” My comment: Biodiversity “…converges upon a ‘common diplotypic proteome (CDP)’, a distinctive subset…

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One test of bioenergetic health?

Success of new-generation metabolo-therapies in personalized medicine depends on measuring bioenergetic health Excerpt: “In one test, a comprehensive measure of energetic health, or its disease-related deterioration, can now be made. The prognostic and diagnostic value of bioenergetic measurements in patients is still unknown, but recent findings support an emerging concept that circulating leukocytes and platelets can serve as the “canary in the coal mine” by acting as early sensors or predictive biomarkers of metabolic function under conditions of chronic stress…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]