Diseases & Disorders

Creation vs evolution of ribonucleotide removal strategies (2)

See first: Creation vs evolution of ribonucleotide removal strategies (1) Special Issue “Non-Coding RNAs in Viral Infections” Guest Editor  Rebecca L. Skalsky Guest Editor Dr. Eva Gottwein Non-coding RNAs (ncRNAs) are key regulators in anti-viral responses and play diverse roles in various aspects of infection, including virus replication, persistence, and pathogenesis. In addition to host Creation vs evolution of ribonucleotide removal strategies (2)

Predicting the CRISPR Cas9 Market Collapse

Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo Knowing that nucleosomes interfere directly with Cas9 cleavage, but not with ZFN cleavage, is useful information. It may explain some cases of unanticipated sgRNA failure, and it should guide specific applications where precisely located, high-efficiency cleavage is necessary. Reported as: CRISPR’s hedgehog problem: Rolled-up genes can’t be Predicting the CRISPR Cas9 Market Collapse

The tipping point (revisited): 77,000 publications (3)

The Future of Chemistry

See: The tipping point (revisited): 77,000 publications (2) Summary: “The resulting genomes can reveal a pathogen’s most intimate evolutionary secrets.” Is Kathryn Holt the enemy? She portrays the virus-driven degradation of messenger RNA in the context of evolutionary secrets without telling anyone about how the Virus-mediated archaeal hecatomb in the deep seafloor has been linked The tipping point (revisited): 77,000 publications (3)

Schrödinger at 75 Day 1

#whatislife75  None of today’s speakers linked sunlight from the physiology of pheromone-controlled reproduction in soil bacteria to biophysically constrained viral latency in the context of quantum effects on supercoiled DNA. What is Life? (1944) Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely Schrödinger at 75 Day 1

Eulogizing McCain (2)

Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis  (7/10/18) is reported to be …an important in vivo demonstration of the relevance of microRNA-mediated communication between neurons and astrocytes. See: Lost in translation: microRNAs mediate pathological cross-talk between motor neurons and astrocytes (8/29/18) Stephen Hawking and John McCain, who like all others died from Eulogizing McCain (2)

Eulogizing McCain

Unlike conspiracy theorists, I cite my sources. In Eulogy, Meghan McCain Takes Swing at Trump Obama: “So much of our politics, our public life, our public discourse can seem small and mean and petty, tracking in bombast and insult and phony controversies and manufactured outrage. It’s a politics that pretends to be brave and tough Eulogizing McCain

The ignorance of Philip C. Ball’s sneaky counter-attack (1)

See: Light-activated polycombic ecological adaptations vs hecatombic pathology (5) Review: A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation  …plants alter microRNA (miRNA) biogenesis in response to light transition. See also: Roles of microRNAs in mammalian reproduction: from the commitment of germ cells to The ignorance of Philip C. Ball’s sneaky counter-attack (1)

MicroRNA-mediated DDT-autism link

First biomarker evidence of DDT-autism link …they point to androgen receptor binding, a process key to neurodevelopment. A study in rats found DDE inhibits androgen receptor binding, an outcome also seen in a rat model of autism. These chemicals are transferred across the placenta in concentrations greater than those seen in the mother’s blood. “Unfortunately, MicroRNA-mediated DDT-autism link

Information Wars started by medical professionals (6)

Disrupted nitrogen metabolism might spell cancer

Summary: Quantized energy-dependent microRNA biogenesis drives the RNA-medated separation of chromosomes when cells divide. See first:  Information Wars started by medical professionals (5) Tide of lies August 17, 2018 This monograph recapitulates my claims 4 days after I started to make them in my series on Information Wars started by medical professionals …they found 11 Information Wars started by medical professionals (6)