Diseases & Disorders

Darwinian theories vs Darwin's facts

“Darwin’s Theories“, submitted by Celia Secades of the Elesapiens website was the runner-up in the Third Annual NESCent Evolution Video Contest. (unfortunately, the video has been removed — perhaps for good reasons. For example: My comment: No experimental evidence supports the representations of mutation-initiated natural selection in the video. For comparison, tenOever on microRNA and Vaccines  addresses what is currently known about glucose-dependent RNA-mediated amino acid substitutions and self vs non-self identification in viruses to living species with varying degrees of nutrient-dependent pheromone-controlled ecologically-adapted organismal complexity.…

Read More

Targeting a cancer gene

‘Undruggable’ mutation meets its match: Six-year effort yields first drug to target important cancer gene See also: Drug discovery: Pocket of opportunity[subscription required] Excerpt: “.,.the non-mutated protein is the beating heart of cell signalling, but mutated versions are the villainous masterminds of malignancies.” and see K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions [subscription required] Excerpt: “…initial evaluation of our compounds in lung cancer cell lines suggests allele-specific impairment of K-Ras function.” My comment: 1) They ignored any aspect…

Read More

Alternative splicings (very technical)

From time to time I try to update my knowledge base on specific aspects included in my model. Here is the link to an open access article that may be of interest to others who want to learn more about biologically based cause and effect. This is not the type of information that you are likely to see in news reported by science journalists. Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition Excerpt 1) DNA…

Read More

Pheromone-controlled thermodynamics and cancer

“If you learnt evolutionary biology and genetics a decade or more ago you need to be aware that those debates have moved on very considerably, as has the experimental and field work on which they are based.” — Denis Noble Can thermodynamics help us better understand human cancers? Excerpt: “In a new study, UCLA researchers analyzed the gene-expression profiles of more than 2,000 patients and were able to identify cancer-specific gene signatures for breast, lung, prostate and ovarian cancers. The…

Read More

Nutrient-dependent pheromone-controlled stickleback evolution

Sexual imprinting on ecologically divergent traits leads to sexual isolation in sticklebacks Excerpt: “Odour differences may be owing to pleiotropic effects of adaptive differences in diet [18], habitat [12] and major histocompatibility complex (MHC) alleles selected by parasite differences [19,20].” Excerpt: “…imprinting has turned odour and nuptial coloration into magic traits.” My comment: In my model, natural odour production in vertebrates is not a magic trait. It results from the role of food odours in nutrient-dependent RNA-mediated ecological niche construction.…

Read More

Functional coding variants are not mutations

Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome “Conclusions: Our results validate the hypothesis that the SERT regulatory network harbors rare, functional variants that impact SERT activity and regulation in ASD, and encourages further investigation of this network as a site for additional functional variation that may impact ASD risk.” My comment: This open access article mentions mutations, but the title and conclusion correctly infer that coding “variants”…

Read More

Mirror neurons and microRNA: theory vs biological facts

Mirror neurons through the lens of epigenetics to be published in Trends in Cognitive Sciences Volume 17, Issue 9, September 2013, Pages 450–457. epub on 14 August 2013 Abstract excerpt: … we propose a new evolutionary developmental biology (evo-devo) perspective, which predicts that environmental differences early in development should produce variations in mirror neuron response patterns, tuning them to the social environment. See Figure 1: Excerpt: “…the early social experience produces modifications in gene expression through epigenetic marks, such as…

Read More