Diseases & Disorders

Some neuroscientists think a mutation led to human language development

Neuroscientists identify key role of language gene Excerpt: “Neuroscientists have found that a gene mutation that arose more than half a million years ago may be key to humans’ unique ability to produce and understand speech.” Excerpt: “…the gene that allowed us to speak may have something to do with a special kind of learning, The gene was first identified in a group of family members who had severe difficulties in speaking and understanding speech, and who were found to…

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Genotype, observed phenotype, and distinctly disordered behaviors

Schizophrenia not a single disease but multiple genetically distinct disorders September 15, 2014 By Jim Dryden News article excerpt: “Genes don’t operate by themselves,” said C. Robert Cloninger, MD, PhD, one of the study’s senior investigators. “They function in concert much like an orchestra, and to understand how they’re working, you have to know not just who the members of the orchestra are but how they interact.” My comment: Robert Cloninger and Jay R. Feierman were psychiatry post-doc residents at…

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Is the problem an internet echo or Feierman's ethics?

Docosahexaenoic acid (DHA) is an omega-3 fatty acid. It is found in cold water fatty fish… On 9/19/13, I posted here and to the evolutionary psychology yahoo group  (msg #152240) on the link between Aquatic Ape Theory, dietary DHA, my model, and brain development. Today, the moderator of the human ethology yahoo group posted a 9/13/13 link (msg # 49666) to Diet During Pregnancy and Early Life May Affect Children’s Behavior and Intelligence Excerpt: “Eating oily fish is also very…

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Mechanisms that are not understood increase clarity

Science 12 September 2014: Vol. 345 no. 6202 pp. 1240-1241 DOI: 10.1126/science.1252966 Perspective RNA Function RNA and dynamic nuclear organization John Rinn1,2,3, Mitchell Guttman4 Excerpt: “While the mechanism for how lncRNAs establish these domains is not fully understood, it is becoming increasingly clear that lncRNAs are important at all levels of nuclear organization—exploiting, driving, and maintaining nuclear compartmentalization.” My comment to Science Magazine: Title: RNA and dynamic nuclear organization Received: Fri, 12 Sep 2014 03:12:03 -0400 Your Comment: The authors…

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Nutrient-dependent erythropoiesis and anemia

A critical role for mTORC1 in erythropoiesis and anemia Excerpt 1): “Cells must coordinate their rate of growth and proliferation with the availability of nutrients. mTOR , a serine-threonine kinase, is one the key proteins responsible for nutrient signaling in eukaryotic cells. mTOR is activated by conditions that signal energy abundance, such as the availability of amino acids, growth factors, and intracellular ATP. Activated mTOR then phosphorylates a set of downstream targets that promote anabolic processes, such as protein translation…

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Biophysically constrained beginnings of RNA and DNA

Any anonymous participant in the discussion of: DNA may have had humble beginnings as nutrient carrier (Sep 01, 2014 by Adam Hadhazy) asks: “when are you going to keep quiet?” In a series of responses, I have explained the problem I have with honoring his request. The following excerpts from Wikipedia and other sources are loosely strung together because there is no point to providing more extensive details of biologically-based cause and effect until others accept the fact that mutations…

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A microRNA-mediated mechanism that is epigenetically inherited

Pregnancy Stress Spans Generations The stressors a female rat experiences during pregnancy can have repercussions for her granddaughters, a study shows. By Anna Azvolinsky | August 7, 2014 Excerpt: “These changes could be the result of a microRNA (miRNA)-mediated mechanism, which may be epigenetically inherited across generations.” My comment:  There is currently no alternative explanation for these changes. However, a model of how nutrient-dependent pheromone-controlled amino acid substitutions link cell type differentiation (e.g., from the epigenetic landscape to the physical landscape of DNA in…

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Drunks and Monkeys: Pseudoscientific nonsense

Drunks and Monkeys Understanding our primate ancestors’ relationship with alcohol can inform its use by modern humans. By Robert Dudley | June 1, 2014 Excerpt: “…if the right kinds of bacteria are also present, fermentation will stabilize certain foodstuffs (think cheese, yogurt, sauerkraut, and kimchi, for example).” My comment:  Epigenetic changes induced by ethanol in astrocytes link histone acetylation, DNA methylation, and non-coding microRNAs in the developing and adult brain from frugivory to the nutrient-dependent de novo creation of olfactory receptor genes in bats. The…

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MiRNAs methylation and ecological adaptation sans mutations

MiRNAs methylation and ecological adaptation sans mutations  “Our 2003 Molecular and Cellular Biology paper …opened the mechanistic ‘black box’ of the developmental origins of adult disease susceptibility, and firmly placed the word, epigenetics, in the vernacular of this research field.”  — Randy Jirtle (2009) Our 1996 Hormones and Behavior paper included a section on molecular epigenetics with evidence that attested to the involvement of epigenetics in the context of olfactory/pheromonal input and the developmental origins of hormone-organized and hormone-activated adult sexual behavior.…

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Darwinian theories vs Darwin's facts

“Darwin’s Theories“, submitted by Celia Secades of the Elesapiens website was the runner-up in the Third Annual NESCent Evolution Video Contest. (unfortunately, the video has been removed — perhaps for good reasons. For example: My comment: No experimental evidence supports the representations of mutation-initiated natural selection in the video. For comparison, tenOever on microRNA and Vaccines  addresses what is currently known about glucose-dependent RNA-mediated amino acid substitutions and self vs non-self identification in viruses to living species with varying degrees of nutrient-dependent pheromone-controlled ecologically-adapted organismal complexity.…

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