Adaptations

From optoribogenetics to HelioRiboGenetics (3)

See first: From optoribogenetics to HelioRiboGenetics (2) and From optoribogenetics to HelioRiboGenetics (1) “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Circulating microRNAs associated with liver fibrosis in chronic hepatitis C patients Chronic hepatitis C (CHC) evolves in 20% of cases to liver cirrhosis after progressive stages of fibrosis (Center for Diseases Control and Prevention – CDC, 2019). The most serious complication…

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From optoribogenetics to HelioRiboGenetics (2)

See first: From optoribogenetics to HelioRiboGenetics (1) For consistency see Abcam’s: Spotlight on Neuroscience [and the 2020 Nobel Prize for Physiology or Medicine] Abcam’s forthcoming live sessions Adult Neurogenesis  Building and Reparing the Brain Epigenetics in the Nervous System On-demand webinars Role of chronic inflammation in risk for neurodegenerative disorders: Alzheimer’s disease Autophagy and Neurodegeneration Chronic virus-driven inflammation perturbs epigenetic effects on energy-dependent microRNA-mediated autophagy, which prevents neurodegeneration. Attempts to discredit Judy A. MIkovits for her role in linking God’s…

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From optoribogenetics to HelioRiboGenetics (1)

Optoribogenetic control of regulatory RNA molecules 9/24/20 “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Had he lived, Bruce S. McEwen probably would have received the 2020 Nobel Prize in Physiology or Medicine for linking God’s Creation of UV light and water from energy-as-information to biophysically constrained viral latency across kingdoms. McEwen et al., (1964) linked that heliocentric approach to scientific creationism…

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Optoribogenetic-driven sympatric speciation (2)

See the 7-part series: Predicting who wins the 2017 Nobel Prizes (7) Conclusion: The biggest threat to humanity is not the “Big Bang” theory of creation or the “Big Bang” theory of how life on Earth might end after an explosion of cosmic proportions. The biggest threat has always been “human idiocy.” For examples of human idiocy, see anything published by any researcher or any research group that failed to link God’s Creation of UV light and water from oxidative…

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Optoribogenetic-driven sympatric speciation (1)

For presentation during session: Polycomb and chromatin remodeling Historical perspective: Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes… Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at…

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UV light, H2O, and epigenetic effects… (2)

UV light, H2O, and epigenetic effects… (1) 9/25/20 During the 9/26/20 “Benghazi and Twin Towers Memorial Ride and Veterans Event” at Band of Brothers Veterans Park in Murphy, North Carolina,  DW (Del) Wilber ( guest speaker and “Counterterrorism Analyst”) reminded me that in 2006, Greg Bear’s Quantico was near future, hard counterterrorism science fiction. Historical perspective:Greg Bear is the author of more than thirty books, spanning thrillers, science fiction, and fantasy, including Blood Music, Eon, The Forge of God, Darwin’s…

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UV light, H2O, and epigenetic effects… (3)

Trump nominates conservative Amy Coney Barrett for Supreme Court She would be the only justice on the current court not to have received her law degree from an Ivy League school. The eight current justices all attended either Harvard or Yale. Most researchers at Harvard and Yale failed to admit, and failed to teach their students, that God’s Creation of UV light and water biophysically constrains viral latency across kingdoms via oxidative phosphorylation. They are being forced to tell the…

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UV light, H2O, and epigenetic effects… (1)

See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective,…

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Coherently organized healthy longevity (3)

  Development of MicroRNAs as Potential Therapeutics against Cancer 7/15/20 The perfect pairing of the miRNA with the target mRNA promotes mRNA degradation, while imperfect base pairing will lead to protein translational repression. God’s UV light-activated “Perfect Pairing” prevents cancer and all other forms of virus-driven pathology. See: Light-mediated strong coupling between a mechanical oscillator and atomic spins 1 meter apart 5/10/20 To achieve quantum-coherent coupling (40), g must also exceed all thermal and quantum back-action decoherence rates. This is…

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The microRNA-mediated fight against COVID-19 (1)

History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

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