Genomic surveillance ends our world of RNA-mediated ecological adaptations

Why is this woman smiling? 1) Identifying Recent Adaptations in Large-Scale Genomic Data Senior author: Sabeti with co-author Rinn Excerpt: “As natural selection can only act on mutations that drive phenotypic variation…”. 2) Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak  Senior author: Sabeti. Excerpt: “Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.” 3) RNA and…

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Physics, Chemistry, and Molecular biology (PCMb)

Physics, Chemistry, and Molecular biology (PCMb) link ecological variation to ecological adaptations via a model of gene-cell-tissue-organ-organ system complexity that I first presented in 1992. After adding gene activation by pheromones, I co-authored a book that linked the pheromone-controlled physiology of reproduction across species from microbes to man: The Scent of Eros: Mysteries of Odor in Human Sexuality (1995/2002) Since then, others have written books that claimed that pheromones evolved: Pheromones and Animal Behaviour (2003/2014) and one claimed that mammals…

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Physics denied; pseudoscientific nonsense accepted

  The events depicted are now portrayed in the context of Genome Dynamics Events, which are biophysically-constrained RNA-mediated events. RNA-mediated events lead to amino acid substitutions that differentiate the cell types of species. For example: “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.” Dobzhansky (1973) See also: God, Darwin and My College Biology Class By DAVID P.…

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Ecological variation and niche construction: 1, 2, 3

Part 1 From its most basic expression in grazing and predatory nematodes with differences in morphological and behavioral phenotypes, neurogenic niche construction is nutrient-dependent and pheromone-controlled. One of these two worms has teeth. It also recognizes self vs other differences and eats other worms. “The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding behaviours of P. pacificus and C. elegans”, Ralf Sommer concludes. Evolutionary theorists concluded and continue to claim that “…without mutation, evolution would not…

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Epigenetically-effected metabolic shifts and ecological adaptations

Epigenetics of Trained Innate Immunity: Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages. By Ruth Williams | September 25, 2014 [open access] Excerpt: “…they then analyzed genome-wide distributions of four epigenetic indicators of gene activity: DNAse hypersensitivity and three different histone modifications—trimethylation of histone H3 at lysine 4, monomethylation of histone H3 at lysine 4, and acetylation of histone H3 at lysine 27. They also analyzed genome-wide transcription and transcription factor binding. Together…

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Did our adapted mind evolve? (Revisited)

Did our adapted mind evolve? In my extended comments on this topic I concluded with “Experience-dependent changes in DNA methylation can exert profound effects on neuronal function and behaviour. A single learning event can induce a variety of DNA modifications within the neuronal genome, some of which may be common to all individuals experiencing the event, whereas others may occur in a subset of individuals.” The experience-dependent changes are due to RNA-directed DNA methylation (i.e., RNA-mediated events, not evolutionary events).…

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Did our adapted mind evolve?

What is currently know about neuroendocrine regulation clearly links ecological variation to ecological adaptations manifested in morphological and behavioral phenotypes via RNA-mediated events without the pseudoscientific nonsense of evolutionary theory. Evidence that biological facts about cause and effect make no difference to theorists shows up in what we can expect from conference presentations next year. ADAPTED MIND, ADAPTED BODY: THE EVOLUTION OF HUMAN BEHAVIOR AND ITS NEUROENDOCRINE REGULATION The idea that the human behavior evolved in the context of neuroendocrine…

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RNA-directed DNA methylation and RNA-mediated events

Many colleagues and most of my antagonists seem to be unwilling to accept the fact that RNA-directed DNA methylation links the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man. Lack of acceptance appears to be due to the fact that they think mutations and natural selection link evolutionary events to biodiversity. There is no model for that, but they refuse to accept the fact that RNA-mediated events link ecological variation…

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Miracles are not miracles to evolutionary theorists

Science 19 September 2014: Vol. 345 no. 6203 pp. 1443-1445 DOI: 10.1126/science.345.6203.1443 No miracles Excerpt: “There’s a reason these crows make tools and other birds don’t,” he says. “It’s not a miracle.” THAT SENTENCE, along with the even shorter phrase “no miracles,” is a favorite of Gray’s. The power of evolution “to explain many things,” as he puts it, struck him when he was still in high school in Tauranga, south of Auckland, after reading Richard Dawkins’s The Selfish Gene.”…

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Mathematical model: microRNA and epigenetic regulation

Hypothesis & Theory ARTICLE Front. Genet. | doi: 10.3389/fgene.2014.00345 Interplay of microRNA and epigenetic regulation in the human regulatory network. Excerpt: “…a detailed model of the epigenetic interaction and its relations with the cellular environment would be required, and this is still an open issue (24).” My comment: Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Conclusion:  “Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’.” The model starts with…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]