Human Brain

Making sense of quotes scattered across disciplines

Speaking of Science November 2014’s selection of notable quotes By The Scientist Staff | November 1, 2014 My comment: The quotes are scattered from across disciplines, but can be linked to what is known about conserved molecular mechanisms of biologically-based cause and effect that, in context, make sense of them. 1) Cell type differentiation occurs via amino acid substitutions in the Ebola viruses. Identification of two amino acid residues on Ebola virus glycoprotein 1 critical for cell entry 2) What…

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Intelligent viruses and cancers?

The Very Intelligent Ebola Virus Takes Front and Center Excerpt 1) “Ebola doesn’t enter the nucleus. It uses the cell’s machinery of ribosomes and transfer RNA to make proteins from the viral messengerRNA.” Excerpt 2) “Normally, mechanisms inside the nucleus have complex relations with messenger RNA and the alternative RNA editing process (see RNA alternative editing post). Specific protein complexes help splice the messengerRNA before it is sent from the nucleus to the ribosomes in the cytoplasm to make proteins.”…

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2014 and 2004 Nobel Prize in Medicine

2014 Nobel Prize in Medicine is Awarded for Discovery of Brain’s ‘Inner GPS’ Excerpt: “… gray lines show the path followed by a rat as it moves around a box looking for pieces of food.” 2014 Nobel prize in physiology or medicine for finding brain’s ‘you are here’ cells Excerpt: John Stein, professor of physiology at Oxford University, said: “This is great news and well deserved. I remember how great was the scoffing in the early 1970s when John first…

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Color vision refutes the evolutionary dogma of gene duplication

The Rainbow Connection Color vision as we know it resulted from one fortuitous genetic event after another. By Kerry Grens | October 1, 2014 Excerpt 1: “The fact that we have the same few amino-acid substitutions as New World monkeys argues there was a single ancestral variation that gave rise to [the cone opsins of] both Old and New World primates,” Nathans says. “It leads to an interesting twist on the evolutionary dogma of gene duplication.” My comment: The fact…

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Systems biology and memory disorders

Reversal of cognitive decline: A novel therapeutic program Reported as: Memory loss associated with Alzheimer’s reversed: Small trial succeeds using systems approach to memory disorders News Article Excerpt: (1) eliminating all simple carbohydrates, leading to a weight loss of 20 pounds; (2) eliminating gluten and processed food from her diet, with increased vegetables, fruits, and non-farmed fish; (3) to reduce stress, she began yoga; (4) as a second measure to reduce the stress of her job, she began to meditate…

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RNA-mediated cell type differentiation and behavior

Neuroscience Meeting Planner Now Available The Preliminary Program and Neuroscience Meeting Planner for Neuroscience 2014 are available. At the 2012 Meeting I learned that the microRNA/messenger RNA balance had emerged during the past decade to be the most likely regulator of all downstream effects on cell type differentiation. That inspired me to focus on what I knew about RNA-mediated events and put what we detailed about them in our 1996 Hormones and Behavior review into the context of a this…

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Metabolism, fixation, health or neurodegerative disorder

“Shown is the location of the conserved regions encoding for the N-terminal chromo domain and the C-terminal MYST functional domain. An arrow denotes the position site of amino acid substitution E431Q.” Microarray Analysis Uncovers a Role for Tip60 in Nervous System Function and General Metabolism My comment: The article links a nutrient-dependent amino acid substitution via changes in metabolism to cell type differentiation, multicellularity, and brain development in Drosophila. It suggests the substitution is fixed by the model organism’s pheromone-controlled…

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Ecological variation and niche construction: 1, 2, 3

Part 1 From its most basic expression in grazing and predatory nematodes with differences in morphological and behavioral phenotypes, neurogenic niche construction is nutrient-dependent and pheromone-controlled. One of these two worms has teeth. It also recognizes self vs other differences and eats other worms. “The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding behaviours of P. pacificus and C. elegans”, Ralf Sommer concludes. Evolutionary theorists concluded and continue to claim that “…without mutation, evolution would not…

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Did our adapted mind evolve?

What is currently know about neuroendocrine regulation clearly links ecological variation to ecological adaptations manifested in morphological and behavioral phenotypes via RNA-mediated events without the pseudoscientific nonsense of evolutionary theory. Evidence that biological facts about cause and effect make no difference to theorists shows up in what we can expect from conference presentations next year. ADAPTED MIND, ADAPTED BODY: THE EVOLUTION OF HUMAN BEHAVIOR AND ITS NEUROENDOCRINE REGULATION The idea that the human behavior evolved in the context of neuroendocrine…

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Watching and waiting for more retractions

Brain Genetics Paper Retracted A study that identified genes linked to communication between different areas of the brain has been retracted by its authors because of statistical flaws. By Anna Azvolinsky | September 4, 2014 Excerpt: “This retraction raises the issue of how many papers may have falsely reported gene associations because of the constantly evolving changes in gene assemblies and boundaries. That’s really alarming to me.” My comment: I am alarmed by those who report anything in terms of…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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