RNA-Mediated

Published May 3, 2017 Genetic variation and RNA structure regulate microRNA biogenesis …primary sequence determinants and RNA structure are key regulators of miRNA biogenesis. Genetic variation aka primary sequence determinants are energy-dependent and RNA-mediated. Energy-dependent RNA methylation is an experience-dependent link from natural selection for energy-dependent codon optimality. Natural selection for energy-dependent codon optimality links ATP-dependent microRNA biogenesis to RNA biosynthesis. Ridiculous attempts to portray energy-dependent top-down causation as if genetic variation came first may continue for another 52 years.…

Ignoring peer review, ATP, and microRNA biosynthesis

April 29, 2017

Adaptations, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations

Cell diversity and network dynamics in photosensitive human brain organoids …neuronal activity within organoids could be controlled using light stimulation of photosensitive cells, which may offer a way to probe the functionality of human neuronal circuits using physiological sensory stimuli. They are not going to tell anyone that these findings link the speed of light on contact with water to the energy-dependent physiology of reproduction in all living genera because the physiology of reproduction is nutrient-dependent and pheromone-controlled. Everyone knows…

Virus-driven downsizing of the human brain (4)

April 23, 2017

Adaptations, Ecology, Human Pheromones, Model Organisms, Variations

Virus-driven downsizing of the human brain (7/1/16) Virus-driven downsizing of the human brain (2) (7/6/16) Virus-driven downsizing of the human brain (3) (8/9/16) Excerpt: A Postdoctoral Researcher threatened me with litigation if I did not remove the tags with his name that linked his works to works at the institution where he works. In an attempt to discuss Breakthrough in understanding how stem cells become specialized More than two years ago, he wrote: We house our animal mouse models in…

Feng Zhang refutes theistic evolution

April 20, 2017

Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated gene silencing, Variations

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Nucleic acid detection with CRISPR-Cas13a/C2c2 My summary: Their ability to detect single base differences links differences in the energy of photons to the light-induced de novo creation of RNA and to RNA-mediated amino acid substitutions that differentiate all cell types in all individuals of all living genera. Any claims about mutations and evolution have already been replaced by what serious scientists have learned about natural selection for energy-dependent codon optimality and the pheromone-controlled physiology of reproduction, which biophysically constrains all…

Epigenetically-effected nucleosome repositioning sheds Dobzhansky’s light on evolution

April 14, 2017

Adaptations, Alternative Splicings, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations

Crystal structure of the overlapping dinucleosome composed of hexasome and octasome My summary: Nucleosomes are dynamic entities that are repositioned by energy-dependent links from sunlight to ATP and RNA biosynthesis that act on DNA during the chromatin remodeling, which is biophysically constrained by the pheromone-controlled physiology of reproduction during the transgenerational epigenetic inheritance of all morphological and behavioral phentoypes. processes. Reported as: Unveiling how nucleosome repositioning occurs to shed light on genetic diseases …an incomplete formation of overlapping dinucleosome may…

Virus-driven dietary pathology (1)

April 7, 2017

Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations

Viral Trigger for Celiac Disease? A common, seemingly benign human virus can trigger an immune response that leads to celiac disease in a mouse model, researchers show. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease Editor’s summary: Viruses compound dietary pathology Reoviruses commonly infect humans and mice asymptomatically. Bouziat et al. found that immune responses to two gut-infecting reoviruses take different paths in mice (see the Perspective by Verdu and Caminero). Both reoviruses invoked protective immune…

Light-activated feedback loops vs self-organization of ecosystems

March 30, 2017

Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations

John Lieff has been trying to update his ridiculous misrepresentations of biologically-based cause and effect to match the accurate representations we made in a section on molecular epigenetics in our 1996 Hormones and Behavior review. From Fertilization to Adult Sexual Behavior Nothing can stop him, but this will provide the next source for material that he must borrow as if he learned about it somewhere else. Apoptosis analysis guide | Free ebook download Virus-driven energy theft causes apoptosis, which releases…

Sal Giardina: apologetics revisited

March 27, 2017

Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations

March 26, 2017 Sal Giardina wrote: “James, I appreciate your responding to my posts but I would prefer that your input would be related to the content of the post.” My reply: If you do not want people to learn how my claims are linked to yours, please tell me that you intend to continue with apologetics rather the concept of energy as information. Apologetics: … the religious discipline of defending or proving the truth of religious doctrines through systematic…

Where do sex differences come from?

March 23, 2017

Adaptations, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA methylation

3/22/17 Study identifies brain cells involved in Pavlovian response “The mice learned to associate the new scent with food, just like Pavlov’s dogs,” said Masmanidis, who is also a member of UCLA’s California NanoSystems Institute and Brain Research Institute. “Our next step was to uncover what happens to the Pavlovian response when we silence different groups of cells in the striatum.” Classically conditioned responses link the experience-dependent de novo creation of G protein-coupled receptors from food odors and pheromones to…

Thinking about energy is not radical re-thinking

March 19, 2017

Adaptations, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations