Human Pheromones

Methylation maintains cell type differences (2)

Follow up to:  Methylation maintains cell type differences Brain’s ‘gender’ may be quite flexible: Mechanism that plays key role in sexual differentiation of brain described Excerpt: “Prof. McCarthy is now doing additional research on the links between the immune system and brain sex differences.” See also: An immune hypothesis of sexual orientation Excerpt: “…this ICS-hypothesis is consistent with the fact that many mfTSs can have children and does not preclude effects of odors and pheromones, but elucidates why those substances…

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Methylation maintains cell type differences

Female Brain Maintained by Methylation Development of female sexual behaviors requires DNA methylation in the preoptic area of the rodent brain. By Anna Azvolinsky | March 30, 2015 Excerpt: “…programmed during brain development, but how exactly this occurs is not clear. In the preoptic area (POA) of the brain…” My comment: See the section on molecular epigenetics in our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior Excerpt: “Small intranuclear proteins also participate in generating alternative splicing…

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The quantum / classical RNA-mediated ‘tipping point’

Researchers identify ‘tipping point’ between quantum and classical worlds Excerpt: “Any popular explanation of quantum theory usually begins with Schroedinger’s cat – a thought experiment describing a cat inside a closed box, that may be either dead or alive,” Vered says. “Rather than looking at the tipping-point between life and death, our experiment examines the point at which quantum behavior gives way to classical physics. Since quantum behavior kicks in at a very small scale, one could liken our results…

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RNA-directed gene choice

March 2015: ChemoSense; see Timothy S. McClintock: “Odorant Receptor Gene Choice” He concludes: “The epigenetic control of OR gene expression through repression and de-repression is a remarkable story, and as a fundamental mechanism intimately associated with the random differentiation of a neural progenitor cell into multiple neuronal subtypes, one wonders whether it might be a framework for understanding other instances of differentiation of neural subtypes (Lyons and Lomvardas, 2014).” My comment: The epigenetic control of OR gene expression is RNA-directed…

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RNA directed DNA methylation and cell types

Cell type differentiation is included in all topics in biology, which is why it is important to understand what is currently known about top-down causation in the context of physics and chemistry. Taken together, physics, chemistry, and the conserved molecular mechanisms of biology link Drosophila to Octopuses and all other species on this planet via RNA-directed DNA methylation and RNA-mediated amino acid substitutions that differentiate cell types. See for examples: Let there be anti-entropic light (1) An antagonist led me…

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RNA-mediated repurposing in microbes and adaptations in primate brains

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion Excerpt: “…the C-terminal 47 amino-acids of ARHGAP11B (after lysine-220) constitute not only a unique sequence, resulting from a frameshifting deletion (fig. S10), but also are functionally distinct from their counterpart in ARHGAP11A.” My comment: Co-author Svante Paabo is the senior author of this 2003 publication: Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees The 2015 publication was reported as: A gene for brain size only found…

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An epigenetic trap (the prequel)

See also: An epigenetic trap (the sequel) Excerpt: “Support for the link from one epigenetic trap to cell type differentiation was included in the molecular epigenetics section of our 1996 review, which detailed how RNA-mediated chromatin remodeling occurs.” My comment: One epigenetic trap leads to the de novo creation of olfactory receptor genes and cell type differentiation. See also: Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons. The first epigenetic trap links the sun’s biological energy to cell type…

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Imagining that data historically supports evolutionary theory

1) Arguments in the evo-devo debate: say it with flowers! Abstract excerpt: A key question in evolutionary developmental biology is how DNA sequence changes have directed the evolution of morphological diversity. The widely accepted view was that morphological changes resulted from differences in number and/or type of transcription factors, or even from small changes in the amino acid sequence of similar proteins. My comment: This is the first time I have seen anyone claim that the “…small changes in the…

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Atheism: Arrogant, useless, and divisive ignorance

Scientific Seeker Stuart Kauffman on Free Will, God, ESP and Other Mysteries By John Horgan | February 4, 2015 Excerpt: Horgan: What do you make of the antipathy toward religion expressed by Richard Dawkins and other “New Atheists?” Kauffman: … moral behavior requires no belief in God. Morality probably evolved in Paleolithic to some extent. But to dismiss those who do believe in God, in any sense, is arrogant and useless and divisive. Excerpt: We need accelerating expansion of universe for…

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Environment epigenetically shapes the immune system

Environment, more than genetics, shapes immune system 1) –with my emphasis Re: “There’s nothing here that is revolutionary or requires rethinking of our assumptions about how the immune system functions…” My comment: They removed assumptions about cell type differentiation by linking differences in metabolic networks to genetic networks. They indirectly showed that ecological adaptations are nutrient-dependent and the adaptations are controlled by the metabolism of nutrients to species-specific pheromones. The pheromones control the nutrient-dependent physiology of reproduction in species from…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]