Human Pheromones

For God and Country

Energy-dependent structure and function: Until death (1)

October 11, 2017
James Kohl
Autophagy, Diseases & Disorders, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA-mediated epigenetic regulation of gene expression, Variations
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The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear mechanism of gating at this site. Furthermore, the smFRET data suggest that allosteric inhibition by zinc occurs by an uncoupling of the agonist-induced changes at…

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Until death: Virus-driven failure of multisensory integration (1)

October 5, 2017
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA-directed DNA methylation, Variations
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Martha McClintock‘s works inspired my works. Publication of “The Scent of Eros: Mysteries of Odor Human Sexualty” (1995) led Denise Chen to study olfaction and pheromones. See for example: Encoding human sexual chemosensory cues in the orbitofrontal and fusiform cortices. Her student, Wen Zhou, returned to China and she is the senior author of Olfaction Warps Visual Time Perception. Since 1995, all accurate representations of how foraging behavior links food odors and pheromones from feedback loops to sexual reproduction and…

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Caught in an epigenetic trap: flag waving consequences

September 28, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA-mediated epigenetic regulation of gene expression, Subatomic, Variations
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Egypt concert-goers arrested for raising rainbow flag This is an example of “flag waving” consequences from another part of the world. They are accused of “public indecency” and “inciting immorality among young people”, the sources said following Monday’s arrests. Why? These protesters were probably caught in an epigenetic trap. See: Search Results for “epigenetic trap” The colors of the rainbow link the anti-entropic virucidal energy of sunlight to epigenetically trapped water in supercoiled DNA and all biophysically constrained biodiversity via…

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For God and Country

Sci-Hub vs limits on the dissemination of information

September 20, 2017
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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The ideology of “Americanism” is not consistent with the tactics of academics and politicians that constrain release of accurate information about  biologically-based cause and effect. …Americanism is an ideology, or belief in devotion, loyalty, or allegiance to the United States of America, or to its flag, traditions, customs, culture, symbols, institutions, or form of government.[2] In the words of Theodore Roosevelt, “Americanism is a question of spirit, conviction, and purpose, not of creed or birthplace.”[3] Americanism has two different meanings.…

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Evolution outside the context of “the light of evolution”

September 13, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
One Comment

Summary: The claim that two mutations led to the weekend resurrection of the bacterial flagellum cannot be supported with the claim that only one amino acid substitution differentiates the cell type of two different primate species (gorillas and humans) from two similar species (chimpanzees and humans). The fact that mutations are not amino acid substitutions can be supported in the context of food energy-dependent pheromone-controlled cell type differentiation in species from microbes to humans. Nothing in Biology Makes Any Sense…

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Optogenetics replaces fMRI but not pseudoscientific nonsense

September 8, 2017
James Kohl
Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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Summary: The ability to evaluate spaciotemporal influences on health compared to virus-driven pathology must include a link from quantized energy to the creation of ATP and the creation of RNA. Hunting people down who are aware of that fact is difficult because most of them have ignored the facts from this 1964 publication. Ed Boyden and Optogenetics: The Future of Neuroscience (video) (transcript) What I’m trying to do now is see whether we can help people pilot crazy projects that…

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Science vs Secularism: Molecular Mechanisms or Math?

September 7, 2017
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, Variations, What's in the News
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Summary: An example from ancient knowledge of trigonometry links pattern recognition as the basis for the science of creationism, and pattern recognition also is the basis for molecular biology. What form of virus-driven pathology would you most like to see eliminated from future consideration by serious scientists who know how energy-dependent RNA-mediated cell type differentiation occurs? In any case, a PubMed search for microRNA and your disease of choice will be enlightening. See for example: microRNA + Alzheimer’s or microRNA…

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MicroRNAs: Nature’s secret ingredient

September 1, 2017
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations, What's in the News
One Comment

The Secret Ingredient That Stops Honeybees From Becoming Queens Learning more about how these molecules can affect species in different kingdoms — like plants and insects or plants and humans — could help identify therapeutic applications for cancer treatments or to suppress allergic reactions, Dr. Askenase said. “Some important biological problems could now be addressed with this new knowledge of how nature works,” he said. Plant microRNAs in larval food regulate honeybee caste development Overall, our study uncovered a new…

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A fear of pheromones (revisited)

September 1, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, RNA Directed, RNA-directed DNA methylation, Variations
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Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference Reported as: Scents and social preference: Neuroscientists ID the roots of attraction “MicroRNAs were ideal candidates for the job,” said Lippi, a project scientist in Berg’s laboratory in the Division’s Neurobiology Section. “They are post-transcriptional repressors and can target hundreds of different mRNAs to consolidate specific genetic programs and trigger developmental switches.” Energy-dependent changes in the microRNA/messenger RNA balance link the physiology of pheromone-controlled reproduction to all healthy longevity in…

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Sexual communication signals: New Insights!

August 31, 2017
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Subatomic
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Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull New insights in the evolution of sexual communication signals Abstract excerpt: Our research focuses on identifying a) the genes underlying sexual signals and responses in both sexes2-4, and b) ecological factors that may cause divergence in…

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