RNA-Mediated

2018 Chemistry Nobel Laureate, Frances H. Arnold failed to link the light-activated assembly of the microRNA-RNA-peptide nanocomplex from microRNA biogenesis to her claims about the evolution of enzymes, which were retracted. See: Nobel Prize-winning scientist Frances Arnold retracts paper 1/3/20 “For my first work-related tweet of 2020, I am totally bummed to announce that we have retracted last year’s paper on enzymatic synthesis of beta-lactams. The work has not been reproducible,” she tweeted. beta-lactamase confers penicillin resistance to various bacterial…

Public Heath Fascism vs Creationism (1)

January 14, 2021

Adaptations, Alternative Splicings, base editing, biophotonics, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Subatomic, Variations

More than 114,000 indexed publications that mention “microRNA” link energy-dependent biophysically constrained viral latency to all biodiversity on Earth via ecological adaptations. See: microRNA Ask “Where did the energy come from?” Difference and similarities linked to energy-dependent epigenetic imprinting across kingdoms were placed into the context of: Structural basis for the final steps of human 40S ribosome maturation 11/18/20 This was reported as: Human ribosome assembly has no counterparts in simpler model organisms 11/23/20 This demonstrates the importance of considering…

Protonated RNA interference vs stupid theories (9)

November 24, 2020

Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA interference, Subatomic, Variations

Operation of a TCA cycle subnetwork in the mammalian nucleus 11/23/20 ignores the fact that God’s Creation of hydrogen and H2O is required to support the biophysically constrained epigenetic effects of sunlight and humidity on organized genomes. For instance, on 4/23/20, President Donald J. Trump linked the effects of sunlight and humidity to the weakening of coronavirus pathology and the end of the COVID19 nonsense via what is known to all intelligent serious scientists about protonated RNA interference and the…

Protonated RNA interference vs stupid theories (7)

November 23, 2020

Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity, Subatomic

See first: Protonated RNA interference vs stupid theories (6) Watch mask-wearing fools dictate that you become more like them before they mandate use of an mRNA vaccine to prevent what has been prevented by food energy and pheromone-regulated genetic processes during the past 5-10,000 years of energy-dependent ecological adaptations. The energy-dependent ecological adaptations were reported in the context of gene-centric theories. See: Gene experts claim they identified human genes that can protect against Covid-19 11/20/20 …current treatments for SARS-CoV-2 infection…

Election day blues for fools who “voted blue” (1)

November 3, 2020

Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity

See first: microRNA-mediated quantum error correction (4) See also: Biofluorescence in the platypus (Ornithorhynchus anatinus) 10/15/20 was reported as The Mystery of The Platypus Deepens With The Discovery of Its Biofluorescent Fur 10/31/20 If nothing else, the discovery is a nice reminder of our sheer ignorance. See: Epigenetics – From Bench to Clinic starts today, 11/3/20 Live Sessions include information on: RNA modifications and epitranscriptomics11/3/20 Polycomb and chromatin remodeling 11/9/02 DNA-dependent epigenetic events 11/16/20 Histone-mediated epigenetics 11/18/20 The facts may…

Protonated RNA interference vs stupid theories (4)

November 2, 2020

Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA interference, Subatomic

Remember, a vote for Joe Biden, and/or other Democrats, is a vote for more unnecessary suffering and premature deaths. See first: Protonated RNA interference vs stupid theories (3) See also: The first report on circulating microRNAs at Pre- and Post-metamorphic stages of axolotls 10/22/20 Comparison with previous reports on axolotl miRNAs unraveled common and unique members of the axolotl circulating miRNome. Overall, this work provides novel insights into non-mammalian aspects of circulating miRNA biology and expands the multi-omics toolkit for…

Protonated RNA interference vs stupid theories (2)

October 29, 2020

Adaptations, Alternative Splicings, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic

Protonated RNA interference vs stupid theories (1) Evidence for Hidden Involvement of N3-Protonated Guanine in RNA Structure and Function 1/31/19 Charged nucleobases have been found to occur in several known RNA molecules and are considered essential for their structure and function. Estimating Strengths of Individual Hydrogen Bonds in RNA Base Pairs: Toward a Consensus between Different Computational Approaches 4/30/19 Noncoding RNA molecules are composed of a large variety of noncanonical base pairs that shape up their functionally competent folded structures.…

Protonated RNA interference vs stupid theories (1)

October 28, 2020

Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Physics, RNA interference, Subatomic, Variations

Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 …microRNA maturation efficiency may be encoded in the intrinsic dynamic ensemble of primary and precursor microRNAs, providing a potential means of regulating microRNA biogenesis in response to environmental and cellular stimuli. See for comparison: The landscape of host genetic factors involved in immune response to common viral infections 10/27/20 Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response…

microRNA-mediated quantum error correction (4)

October 27, 2020

Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Physics, RNA Directed, RNA interference

I’ve posted presentation abstract submissions here because I anticipated they would not be selected for presentation. See: UV light, H2O, and epigenetic effects… (1) 9/25/20 Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics Moderator Tony Kouzarides Conclusion: Theorists who ignore the role of nutrition in biophysically constrained viral latency are largely to blame for all extant diseases. 21 See for instance: The Secret Language of Cells:…

The tipping point (revisited): 110K (2)

October 22, 2020

Adaptations, Alternative Splicings, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Neuronal Plasticity, Physics, RNA Directed, RNA interference