Light Energy

Viruses, amino acids, and somatic cell types (2)

Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain Excerpt: The RNA-seq data enabled us to detect a positive correlation between developmental changes in the magnitude of parental biases and overall gene expression for most imprinted genes. Conclusion: At the level of the organism, our data uncover how paternal and maternal alleles of Bcl-x make vastly different contributions to brain development, a result that has profound implications for the analysis of parentally-inherited polymorphisms in human health. Reported…

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Koonin: viruses killed neo-Darwinism

The environmental influence on epigenetics Excerpt:  Let the (informed) debate begin. My comment: Informed debate is not possible in the ScienceX venue. See for comparison: Riding the Evolution Paradigm Shift With Eugene Koonin Excerpt: “…the new understanding of evolution needs to integrate what we now know about viruses and virus-host interactions which, from my own perspective, has been absolutely one of the key factors of all evolution since the emergence of cells — well, actually even before the emergence of…

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Riding the wrong direction

Riding the Evolution Paradigm Shift With Eugene Koonin Excerpt: The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis… Excerpt: [T]he entire ideology of personalized medicine should be taken with many grains of salt. My comment: Personalized medicine links the conserved molecular mechanisms of biologically-based cause and effect from nutrient-dependent RNA-mediated gene duplication to RNA-mediated amino acid substitutions, which differentiate…

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Decreased phenotypic variation: Faith in Facts

Serious scientists have known for more than a decade that …phenotypic variation decreases through geologic time, because microRNAs (miRNAs) increase genic precision, by turning an imprecise number of mRNA transcripts into a more precise number of protein molecules… See for example: MicroRNAs and metazoan macroevolution: insights into canalization, complexity, and the Cambrian explosion That fact links the anti-entropic epigenetic effects of nutrient-dependent microRNAs to DNA repair in the organized genomes of species from microbes to man. Viruses appear to cause…

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MicroRNA controlled growth and brain development

Navigable networks as Nash equilibria of navigation games Nature Communications | Article  Open Excerpt: Here we show that the ideal maximally navigable networks do share some basic structural properties with the Internet, E.coli metabolic network, English word network, US airport network, the Hungarian road network and a structural network of the human brain. Reported as: Researchers find the organization of the human brain to be nearly ideal Excerpt: “An optimal network in the brain would have the smallest number of…

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Celebrating independence from ridiculous theories

Firework Colors Enhanced by Elements of Life Excerpt: “…these elements are involved in everything from transporting oxygen and releasing hormones to regulating blood pressure and maintaining bone strength. They also give a burst of color when they are added to a fireworks recipe.” My comment: An epigenetic (above the genome) trap links the speed of light in a vacuum to the speed of light when it is slowed on contact with water. The epigenetic trap causes the light-induced de novo…

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Is SUMOylation RNA-directed DNA methylation? (revisited)

See: Is SUMOylation RNA-directed DNA methylation? posted here on 6/16/15 See also: 1) The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3 (subscription required 6/17/15) 2) SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3 (open access 6/23/15) 3) The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton (open access 6/23/15) 4) MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream…

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What I cannot create I eliminate from discussion

New inorganic aromatic ion Excerpt: Aromatic molecules are a staple of organic chemistry. This comment was removed by the site staff for violation of the comments guidelines : Excerpt: “… when a molecule that looks perfectly reasonable does not exist, the reason may be as simple as nobody has yet found a way to make it.”The same claim explains all biodiversity. Although no one has found a way to re-create existing differences in morphological and behavioral phenotypes, theorists think it…

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Rejecting pseudoscientific nonsense

Rejecting Evolutionary Psychology is Rejecting Evolution Discussion on the closed group Applied Evolutionary Psychology includes my comments on several other reports, beginning with: My comments on: Early Code New research points to key properties of transfer RNA molecules and amino acids that may have supported the origin of life on Earth. I wrote: Thanks for providing yet another reason to reject evolutionary psychology.  Acceptance of RNA-mediated links to cell type differentiation in all cells of all individuals of all genera…

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