microRNA editing

RNA-mediated radiosensitivity (1)

I posted this to microRNA.pro after resolve of an access issue. It now appears as part two of The Tipping Point (revisited): 90K (2) I will follow up on the link to RNA-mediated radiosensitivity after consideration of Maximum Entropy (Most Likely) Double Helical and Double Logarithmic Spiral Trajectories in Space-Time, which was reported in today’s news as Kepler’s Forgotten Ideas about Symmetry Could Explain Spiral Galaxies Without the Need for Dark Matter 8/8/19 Watch as everything known about biophysically constrained…

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Information Wars started by medical practitioners (1)

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (Apr 11, 2018) My Summary: The pheromone-controlled physiology of reproduction biophysically constrains viral latency and the transgenerational epigenetic inheritance of healthy longevity in the context of fixation of the EDAR V370A variant. The variant links changes in a single base pair to differences in an amino acid substitution, which links the mouse-to-human model of ecological adaption from microbes to all extant morphological and behavioral biodiversity. See for comparison: Biological Networks: An Introductory…

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Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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NHEJ disruption and HDR correction?

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop is being held in Park Inn by Radisson Pulkovskaya Hotel & Conference Centre St Petersburg, Saint-Petersburg, Russia, September 2-7 2018. We will discuss all aspects…

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An evolutionary theory killer

Cardiac energy metabolism requires units of energy

Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism (First published May 17, 2018 ) Silencing the mRNA of general control of amino acid synthesis 5-like protein 1 reduced acetylation of LCAD and βHAD as well as fatty acid oxidation rates in cardiomyocytes. Thus, hypertrophy in CHDs prevents the postnatal increase in myocardial acetylation, resulting in a delayed maturation of cardiac fatty acid oxidation. The virus-driven theft of quantized energy causes the silencing of mRNA, which generally controls amino…

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Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

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The tipping point (revisited): 74,000 publications

President Trump and Kim Jong Un will probably discuss this fact: All serious scientists have learned that quantized energy-dependent microRNA biogenesis links everything known about the creation of sunlight from the physiology of food energy-dependent pheromone-controlled reproduction to viral latency and healthy longevity in the context of the creation of the innate immune system of bacteria. See also: The tipping point (revisited): 73,000 publications May 16, 2018 In less than one month, nearly 1000 publications have been added to the…

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MicroRNA-mediated alternative splicing (revisited)

Building one molecule from a reservoir of two atoms reported as: Cold chemistry with two atoms. They linked differences in the energy of photons from two different wavelengths of light, 700 nm and 976 nm, to the creation of the molecule NaCs*. They were able to detect molecule formation in the context of atom loss and NaCs* vibrational levels near the dissociation threshold. Detecting resonances that have not been previously observed appears to be the link from quantum physics to…

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Corporate owned microRNA-mediated biodiversity

Corporate control and global governance of marine genetic resources Who owns ocean biodiversity? All biodiversity is quantized energy-dependent and RNA-mediated in the context of the physiology of reproduction and pheromone-controlled RNA interference (RNAi) . Naturally occurring light-activated RNAi ensures viral latency, which helps to ensure healthy longevity. George Church et al, own this patent on RNA interference, which suggests that he and others own all biodiversity in the context of the Virus-mediated archaeal hecatomb in the deep seafloor and patent…

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