Neuronal Plasticity

RNAi 2002 to AI 2021 (10)

The 6-part series on Energy-dependent epigenetic translation to mRNA stability that ran here between 5/12/17 and 5/22/17 predictably links facts about energy-dependent microRNA-mediated chromosomal inheritance to the end of all the stupid theories that were touted by Gene Levinson in Rethinking Evolution: The Revolution That’s Hiding in Plain Sight (2021) See first: RNAi 2002 to AI 2021 (8) Light-activated microRNA biogenesis obviously links God’s energy-dependent Creation of the cell wall across kingdoms via: Biogenesis and Mechanisms of miRNA-Mediated Gene Regulation…

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RNAi 2002 to AI 2021 (8)

Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes 8/12/19 To test whether the inclusion of amino acids addresses this problem, we coupled direct techniques of cryoelectron microscopy and fluorescence microscopy Reported as:  First cells may have emerged because building blocks of proteins stabilized membranes 8/12/19 The stability of membranes is hydrogen-bond (pH) dependent. Nothing known to intelligent serious scientists about top-down causation suggests that stability of cell membranes automagically emerged. See for comparison:  microRNA More than 133,000…

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RNAi 2002 to AI 2021 (5)

In case you are a moronic public health fascist, liberal, atheist, or Communist who missed it, start your new year with facts about how to prevent or to effectively treat all virus-driven diseases. See: Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20, Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 and Peptide synthesis at the origin of life 11/13/20. Don’t wait another year to learn how to link energy-dependent biophysically constrained changes in…

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RNAi 2002 to AI 2021 (4)

Happy New Year. Got SARS-Cov-2 or one of its synthetic mRNA vaccine-induced variants yet? SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes 12/28/21 …we unexpectedly discovered a viral miRNA-like small RNA, named CoV2-miR-O7a (for SARS-CoV-2 miRNA-like ORF7a-derived small RNA). Its abundance ranges from low to moderate as compared to host miRNAs and it associates with Argonaute proteins-core components of the RNA interference pathway. For a historical perspective on the role of microRNA-like small RNAs in viruses,…

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microRNA-mediated cures (10)

Merry Christmas 2021! Summary: microRNA-mediated cures for all virus-driven pathology have been linked from the 2002 Breakthrough of the Year: Small RNAs (12/19/02) to the 2021 Breakthrough of the year: Protein structures for all (12/16/21) via light-activated carbon fixation and biophysically constrained naturally-attenuated viral endemicity/latency in species from cyanobacteria to humans. As presciently predicted in Biblical Genesis, the physiology of pheromone-regulated genetic processes is required. That fact has been exemplified in at least 3 different patents, all of which attest…

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microRNA-mediated cures (8)

A clear indicator of what is required to end the SARS-CoV-2 pandemic was published as: Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review) 12/20/21 The pathophysiology of coronavirus disease 2019 (COVID‑19) is mainly dependent on the underlying mechanisms that mediate the entry of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) into the host cells of the various human tissues/organs.…

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microRNA-mediated cures (7)

Pharmacogenomics: A road ahead for precision medicine in psychiatry 10/6/21 In this 2017 Precision Medicine Virtual Conference presentation, I linked the National Microbiome Initiative from microbial quorum sensing to the physiology of pheromone-regulated genetic processes of reproduction and endogenous RNA interference (#RNAi) via chromosomal rearrangements in flies from the works of Thomas Hunt Morgan (1910) to sympatric speciation across kingdoms. The chromosomal rearrangements link light-activated carbon fixation to the ATP-dependent creation of RNA and fixation of amino acid substitutions links…

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microRNA-mediated cures (5)

“Dead” nucleotides are biophysically constrained pH-dependent single nucleotide substitutions (SNPs). See first: microRNA-mediated cures (4) Remember what’s been known for decades about dead nucleotides, nucleotide substitutions that are biophysically constrained, when you read about the prevention of bioterrorism and public health fascism in Imagination and remembrance: what role should historical epidemiology play in a world bewitched by mathematical modelling of COVID-19 and other epidemics? 6/7/21 …every established respiratory pandemic of the last 130 years has caused seasonal waves of infection…

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microRNA-mediated cures (3)

See first:  microRNA-mediated cures (2) For comparison to Genetic variations creating microRNA target sites…, and Nutrient-dependent/pheromone-controlled adaptive evolution, Masatoshi Nei claimed that nucleotide substitutions, insertion/deletion, segmental gene duplication, genomic duplication, changes in gene regulatory systems, transposition of genes, horizontal gene transfer et al., were mutations. Simply put, simple-minded theorists start with the idea that everything the happens to our supercoiled DNA is a mutation and they link mutations to evolution across billions to millions of years after energy-emerged from the…

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microRNA-mediated cures (2)

If you find a recently published article that does not link “How microRNAs control cell division, differentiation and death” (2005) to healthy longevity instead of virus-driven diseases, please share it for comparison to “Advances in Genetics: Chapter One – miRNA, Development and Disease (2012) and Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors (3/15/12). Neo-Darwinian theorists and Big Bang cosmologists desparately need experimental evidence of energy-dependent top-down causation to support their stupid theories, and…

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