Neuronal Plasticity

Election day blues for fools who “voted blue” (3)

November 4, 2020
James Kohl
Adaptations, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Subatomic
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See first: Election day blues for fools who “voted blue” (2) Medical experts rip Trump’s suggestion that sunlight, disinfectants may treat coronavirus President Donald J. Trump linked God’s Creation of subatomic particles from differences in the energy of positively charged protons and negatively charged electrons to biophysically constrained healthy longevity across kingdoms via the physiology of reproduction. If Biden wins, we are a nation of losers like Jonathan Reiner. Play Biden’s stupid game, wear masks, and practice social distancing, or…

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The tipping point (revisited): 110K (2)

October 22, 2020
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Neuronal Plasticity, Physics, RNA Directed, RNA interference
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Democrats seem to believe that President Trump’s claims about UV light and humidity have not been linked from the end of the COVID-19 nonsense to the end of their party, the end of Communism, the end of atheism, the end of racism and the end of all the liberal BS. Is the link from God’s Creation of UV light and water to ATP-dependent oxidative phosphorylation not perfectly clear to all intelligent people? See for review: From Fertilization to Adult Sexual…

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pH-dependent viral latency (2)

May 24, 2020
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, What's in the News
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New vaccines protect against COVID-19 in non-human primates, study finds 5/20/20 See for comparison: Vaccines do not control pandemics (1) 5/15/20 I reiterate: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/18/18 Amino acid substitutions at these positions were found to be associated with an inability to serotype a strain and are responsible for antigenic changes48. Recently, amino acid substitutions in the three main antigenic regions, especially at positions 96…

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Natural models inspire future therapeutics (2)

June 24, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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An evolutionary theory killer

The concept of a species (3)

June 12, 2018
James Kohl
Alternative Splicings, Autophagy, Cytosis, Diseases & Disorders, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction (2005) This remodeling of LH circuitry could contribute to the chronic deficit in reward function that has been hypothesized to drive the transition to drug addiction. Lena D. van der Stap discussed her role in the publication of this article, which failed to make any assumptions about mutations and/or evolution. James Kohl Did you co-author Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction McEwen told…

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Misleading evidence, Raman Hyperspectroscopy and FB jail

June 5, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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Yesterday, on the topic of vaccines used to prevent Ebola virus transmission, I wrote: …. There is no such thing as an extinct virus. Their ability to steal energy is biophysically constrained until nutrient stress and/or social stress cause their reactivation. I provided a link to The Darwin Code Today, I read about The misleading evidence that fooled scientists for decades After posting this comment to “The Conversation,” I learned I was blocked from posting anything to Facebook. Have you considered…

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From quantum physics to quantum souls (4)

May 30, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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The long-range consequences of food energy-dependent social factors predictably link everything known about social odors called pheromones from the quantized energy in food to metabolism and biophysically constrained viral latency.  Sympatric speciation exemplifies what is known about how quantized energy links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency in species from microbes to humans. In this review of biophysically constrained viral latency and biodiversity, I linked energy-dependent changes from angstroms to ecosystems in the mouse-to-human model of microRNA-mediated amino…

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An evolutionary theory killer

Epigenetic inheritance of spatiotemporal regulation (5)

May 25, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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Thanks for the Stress, Dad As embryos, the researchers found that the mouse offspring, which exhibited more anxious behavior than usual, also had lower miRNA levels, as did the sperm of the male offspring upon maturity. The stress-linked degradation of messenger RNA is caused by virus-driven energy theft, which has been linked to all pathology in species from bacteria to humans.  For example: Neutrons identify critical details in bacterial enzyme implicated in gastric cancer Ronning’s team focused on H. pylori’s…

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Epigenetic inheritance of spatiotemporal regulation (2)

May 23, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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See: Epigenetic inheritance of spatiotemporal regulation Summary: Food energy-dependent changes in base pairs have repeatedly been linked to spatiotemporal regulation of mRNA translation via the pheromone-controlled physiology of reproduction and microRNA-mediated amino acid substitutions that stabilize organized genomes. See:  Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes One SNP rs4713668 (P=4.62 × 10−4) identified in our study, was in LD (r2=0.65) with rs3227, which is one of the three variants recently…

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Epigenetic inheritance of spatiotemporal regulation

May 22, 2018
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Excerpt: The perception of time thus varies between people and may depend at least in part on personality. These results open up a new avenue for studying and manipulating how we process social situations. This could eventually benefit people who struggle with social interactions, such as those with autism spectrum disorders. Link opens the pdf: Olfaction Warps Visual Time Perception Concluding paragraph: In physics, space-time is warped by the distribution of mass and energy in it (Hwaking 1988). Our findings,…

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