Nutrigenomics

The microRNA-mediated fight against COVID-19 (1)

History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

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pH-dependent viral latency (5)

Molecular and biochemical mechanisms of human iris color: A comprehensive review 6/2/20 MicroRNAs also affect melanocyte synthesis, which is usually affected by the downregulation of essential genes involved in pigmentation. Researchers from Iran linked light-activated microRNA biogenesis in plants to the expression genes that effect the number, size and/or the pH of pathways that influence melanin synthesis in the context of human iris color and human skin pigmentation via the L‐tyrosine amino acid precursor. The energy-dependent microRNA-mediated link from the…

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pH-dependent viral latency (4)

My top tweet @microRNApro during the month of March 2018 earned 3,884 impressions. I wrote: See also my series on “Interethnic biodiversity” via this search: Interethnic genetic simiarities and a PubMed search for microRNA See also: Denying Genetics Isn’t Shutting Down Racism, It’s Fueling It 3/30/18 On the male-female divide, for example, Reich cites profound differences, “reflecting more than 100 million years of evolution and adaptation.” On race, he is both agnostic about what we will eventually find out with respect…

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Vaccines do not control pandemics (1)

See: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/16/18 Compared to the G2 RotaTeq vaccine strain, 17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed. Amino acid changes control pandemics. Congo: MSF Ebola vaccination begins 5/30/18 The Ebola vaccine (rVSVDG-ZEBOV-GP) is being used as part of the overall strategy to control the Ebola outbreak. There was no indication that the vaccine strategy…

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The microRNA-mediated future of humanity (8)

The levels of complexity linked to the microRNA-mediated future of humanity can be examined by ages 10-14+ via game-play of: Bacillus (failed project) See instead: Function of miR825 and miR825* as Negative Regulators in Bacillus cereus AR156-elicited Systemic Resistance to Botrytis cinerea in Arabidopsis thaliana 10/17/19 Peptide Players compete to link amino acids to build a peptide chain (a fancy word for a protein). Virulence Players take on the role of viruses and compete to infect a host cell in…

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The microRNA-mediated future of humanity (3)

Light-activated microRNA biogenesis has been linked from the pheromone-controlled physiology of reproduction to healthy longevity via protection from the virus-driven degradation of messenger RNA in all living genera. On 4/21/20 that fact was misrepresented as: Coronavirus has mutated into at least 30 different strains, Chinese study finds. The report was based on this non-peer-reviewed paper Patient-derived mutations impact pathogenicity of SARS-CoV-2 We observed intrapersonal variation and 6 different mutations in the spike glycoprotein (S protein), including 2 different SNVs that…

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The tipping point (revisited): 100K (4)

The wisdom gap The resulting “wisdom gap” leaves us ripe for manipulation… unaware of threats and unprepared for dangers. And as science and technology push the bounds of the possible, the “wisdom gap” will render us increasingly unable to wrestle with how far those bounds should be pushed. Wrestle with this: Why is Oregon still on lock down? Many people want to believe our health authorities know what they’re doing. Intelligent serious scientists know that our health authorities are corrupt.…

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WHO’s ignorance: From roots to shoots (2)

WHO’s ignorance: From roots to shoots (1) Amino acid substitutions within or near the active site of the viral neuraminidase (NA) may affect influenza virus fitness. See: Neuraminidase inhibitor susceptibility and neuraminidase enzyme kinetics of human influenza A and B viruses circulating in Thailand in 2010–2015  The authors cite the World Health Organization’s Summary of neuraminidase amino acid substitutions associated with reduced inhibition by neuraminidase inhibitors” The summary is available as a pdf download. See also: Viral Factors Associated With…

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Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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NHEJ disruption and HDR correction?

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop is being held in Park Inn by Radisson Pulkovskaya Hotel & Conference Centre St Petersburg, Saint-Petersburg, Russia, September 2-7 2018. We will discuss all aspects…

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