Model Organisms

The tipping point (revisited): 110K (1)

It has been 110 years since Thomas Hunt Morgan presciently linked claims from Biblical Genesis to nutrient-dependent pheromone-regulated genetic processes in flies that biophysically constrain viral latency across kingdoms via chromosomal rearrangements and sympatric speciation. Morgan demonstrated that genes are carried on chromosomes and are the mechanical basis of heredity. More than 110,000 indexed published works (one thousand for each year) link optoribogenetics from helioRibogenetics to microRNA-mediated quantum error correction and biophysically constrained healthy longevity across kingdoms via the STEM…

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microRNA-mediated quantum error correction (2)

What Fans of ‘Herd Immunity’ Don’t Tell You 10/19/20 …the White House has all but embraced herd immunity and has also poisoned the public with misinformation, making it all but impossible to get national, near-universal compliance with public health advice for the foreseeable future. Herd immunity exemplifies nutrient-dependent pheromone-controlled ecological adaptations, which annoys neo-Darwinian theorists and Big Bang cosmologists, especially those who also are Trump-haters. See for comparison: Robust Filtering and Noise Suppression in Intragenic miRNA-Mediated Host Regulation 9/21/20 Specifically,…

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microRNA-mediated quantum error correction (1)

On 10/19/20, more than 250 additions to the indexed articles that mention the term ‘microRNA’ appeared after 5 days of what appeared to be a moratorium linked to publication of Thousands of Previously Unknown Phages Discovered in Whole-community Human Gut Metagenomes on 10/14/20 The discovery of the unknown phages was reported by senior author, Eugene Koonin. For a historical perspective see: Riding the Evolution Paradigm Shift With Eugene Koonin (2015) The entire evolution of the microbial world and the virus…

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From optoribogenetics to HelioRiboGenetics (1)

Optoribogenetic control of regulatory RNA molecules 9/24/20 “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Had he lived, Bruce S. McEwen probably would have received the 2020 Nobel Prize in Physiology or Medicine for linking God’s Creation of UV light and water from energy-as-information to biophysically constrained viral latency across kingdoms. McEwen et al., (1964) linked that heliocentric approach to scientific creationism…

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Optoribogenetic-driven sympatric speciation (1)

For presentation during session: Polycomb and chromatin remodeling Historical perspective: Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes… Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at…

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The microRNA-mediated fight against COVID-19 (1)

History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

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Coherently organized healthy longevity (1)

A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

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pH-dependent viral latency (6)

See first: pH-dependent viral latency (5) Researchers from Iran linked light-activated microRNA biogenesis in plants to the expression genes that effect the number, size and/or the pH of pathways that influence melanin synthesis in the context of human iris color and human skin pigmentation via the L‐tyrosine amino acid precursor. The claim on 6/5/20 by Frank M. LaFerla about the links from energy-dependent changes in microbes to humans and racism was retracted on the same day. Thank God, scientific Creationists…

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NIH’s ignorance: from roots to shoots (1)

A plant’s diet, surviving in a variable nutrient environment 3/3/20 links Algal ancestor of land plants was preadapted for symbiosis 10/5/15 from our NIH Director’s ridiculous claims about evolution across billions to millions of years to the fact that George M. Church has abandoned all hope for scientific progress that might otherwise have been achieved from follow-up on the Human Genome Project. See: Korean Genome Project: 1094 Korean personal genomes with clinical information 5/27/20 (with co-author George Church -Department of Genetics,…

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pH-dependent viral latency (4)

My top tweet @microRNApro during the month of March 2018 earned 3,884 impressions. I wrote: See also my series on “Interethnic biodiversity” via this search: Interethnic genetic simiarities and a PubMed search for microRNA See also: Denying Genetics Isn’t Shutting Down Racism, It’s Fueling It 3/30/18 On the male-female divide, for example, Reich cites profound differences, “reflecting more than 100 million years of evolution and adaptation.” On race, he is both agnostic about what we will eventually find out with respect…

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