Model Organisms

Food energy-as-information, and consciousness

Informational Mode of the Brain Operation and Consciousness as an Informational Related System (6/7/19) Conclusion: consciousness could be fully described and understood in informational terms. In the same issue, the food that organisms eat is linked to human consciousness via natural selection for energy-dependent codon optimality. Codon optimality biophysically constrains viral latency via the physiology of pheromone-controlled reproduction and fixation of RNA-mediated amino acid substitutions. The amino acid substitutions link food energy as information to transgenerational epigenetic inheritance of healthy…

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Trump-hating advocates of vaccines + GMOs (2)

Trump-hating advocates of vaccines + GMOs (1) Conclusion: People who understand the facts about how energy-dependent ecological adaptations to viruses across kingdoms and across generations prevent pathology do not need more theoretical models. For instance, see: Genome-Wide Study Reveals a Novel Regulatory Pathway: Translation Affects mRNA Stability in a Codon-Dependent Manner on June 26, 2019. It is time to force theorists to move forward. Trump-hating advocates of vaccines + GMOs (2) For an attempt to return to the neo-Darwinian pseudoscientific…

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Virus-driven downsizing of the human brain (5)

Virus-driven downsizing of the human brain (3) (8/9/16) Virus-driven downsizing of the human brain (4) (4/23/17) Who the heck is James V. Kohl? Thanks for asking. Posted by u/Sphinx_for_hire 3 months ago I’m in biochemistry/toxicology and was reading up on LUCA (aka Last Universal Common Ancestor). While Googling the work of Nick Lane, I stumbled upon the following page absolutely flaying Lane’s and others’ LUCA theories. This guy, James V. Kohl, has many websites in which he writes about human…

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Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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Quantum initiation of cold chemistry vs Hypeology (3)

See: Quantum initiation of cold chemistry vs Hypeology (2) Facts about the quantized energy-dependent creation of reverse transcriptase, an enzyme that converts a sequence in an RNA molecule into a sequence in a DNA molecule, have been placed into the context of social organization. Social organization: The thermodynamic basis The objective of this work is to establish the connection between energy engineering and social organization and to bring social organization under the big tent of physics. Reported as: How physics…

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Quantum initiation of cold chemistry vs Hypeology (2)

See first: Quantum initiation of cold chemistry vs Hypeology (1) Genotype Genotype is a betting and manipulation game about cross-breeding pea plants, as in Gregor Mendel’s famous experiments. Players compete over three generations to predict the traits of new offspring, by controlling the parent plants’ genetic makeup (“genotype”). The offspring are determined by a die-roll at the end of each round and become the starting parents for the next generation. Changing the parent genotypes dramatically alters the likelihood of the…

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NHEJ disruption and HDR correction?

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop is being held in Park Inn by Radisson Pulkovskaya Hotel & Conference Centre St Petersburg, Saint-Petersburg, Russia, September 2-7 2018. We will discuss all aspects…

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An evolutionary theory killer

Cardiac energy metabolism requires units of energy

Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism (First published May 17, 2018 ) Silencing the mRNA of general control of amino acid synthesis 5-like protein 1 reduced acetylation of LCAD and βHAD as well as fatty acid oxidation rates in cardiomyocytes. Thus, hypertrophy in CHDs prevents the postnatal increase in myocardial acetylation, resulting in a delayed maturation of cardiac fatty acid oxidation. The virus-driven theft of quantized energy causes the silencing of mRNA, which generally controls amino…

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Predicting naturally occurring viral latency

KLRD1-expressing natural killer cells predict influenza susceptibility We identified KLRD1-expressing NK cells as a potential biomarker for influenza susceptibility. Expression of KLRD1 was inversely correlated with symptom severity. Our results support a model where an early response by KLRD1-expressing NK cells may control influenza infection. The NK cells are natural killer cells that help to control viral latency This was reported as: Scientists discover biomarker for flu susceptibility  “We found that a type of immune cell called a natural killer…

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An evolutionary theory killer

Quantum initiation of cold chemistry vs Hypeology (1)

Cold chemistry with two atoms Summary For centuries, chemists have written equations representing chemical reactions by using symbols for atoms and molecules; for example, 2H2O + 2Na → 2NaOH + H2. This short notation shows only four reacting particles, but even in a classroom demonstration where a small piece of sodium is dropped in water, the total number of reactants will be on the order of Avogadro’s number (∼6 × 1023). On page 900 of this issue, Liu et al.…

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