Model Organisms

Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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Quantum initiation of cold chemistry vs Hypeology (3)

See: Quantum initiation of cold chemistry vs Hypeology (2) Facts about the quantized energy-dependent creation of reverse transcriptase, an enzyme that converts a sequence in an RNA molecule into a sequence in a DNA molecule, have been placed into the context of social organization. Social organization: The thermodynamic basis The objective of this work is to establish the connection between energy engineering and social organization and to bring social organization under the big tent of physics. Reported as: How physics…

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Quantum initiation of cold chemistry vs Hypeology (2)

See first: Quantum initiation of cold chemistry vs Hypeology (1) Genotype Genotype is a betting and manipulation game about cross-breeding pea plants, as in Gregor Mendel’s famous experiments. Players compete over three generations to predict the traits of new offspring, by controlling the parent plants’ genetic makeup (“genotype”). The offspring are determined by a die-roll at the end of each round and become the starting parents for the next generation. Changing the parent genotypes dramatically alters the likelihood of the…

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NHEJ disruption and HDR correction?

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop is being held in Park Inn by Radisson Pulkovskaya Hotel & Conference Centre St Petersburg, Saint-Petersburg, Russia, September 2-7 2018. We will discuss all aspects…

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An evolutionary theory killer

Cardiac energy metabolism requires units of energy

Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism (First published May 17, 2018 ) Silencing the mRNA of general control of amino acid synthesis 5-like protein 1 reduced acetylation of LCAD and βHAD as well as fatty acid oxidation rates in cardiomyocytes. Thus, hypertrophy in CHDs prevents the postnatal increase in myocardial acetylation, resulting in a delayed maturation of cardiac fatty acid oxidation. The virus-driven theft of quantized energy causes the silencing of mRNA, which generally controls amino…

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Predicting naturally occurring viral latency

KLRD1-expressing natural killer cells predict influenza susceptibility We identified KLRD1-expressing NK cells as a potential biomarker for influenza susceptibility. Expression of KLRD1 was inversely correlated with symptom severity. Our results support a model where an early response by KLRD1-expressing NK cells may control influenza infection. The NK cells are natural killer cells that help to control viral latency This was reported as: Scientists discover biomarker for flu susceptibility  “We found that a type of immune cell called a natural killer…

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An evolutionary theory killer

Quantum initiation of cold chemistry vs Hypeology (1)

Cold chemistry with two atoms Summary For centuries, chemists have written equations representing chemical reactions by using symbols for atoms and molecules; for example, 2H2O + 2Na → 2NaOH + H2. This short notation shows only four reacting particles, but even in a classroom demonstration where a small piece of sodium is dropped in water, the total number of reactants will be on the order of Avogadro’s number (∼6 × 1023). On page 900 of this issue, Liu et al.…

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Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

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An evolutionary theory killer

The concept of a species (3)

Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction (2005) This remodeling of LH circuitry could contribute to the chronic deficit in reward function that has been hypothesized to drive the transition to drug addiction. Lena D. van der Stap discussed her role in the publication of this article, which failed to make any assumptions about mutations and/or evolution. James Kohl Did you co-author Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction McEwen told…

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The concept of a species (1)

In an attempt to discuss The misleading evidence that fooled scientists for decades I wrote: The concept of a species is clearly seen in the context of Darwin’s “conditions of life” and sympatric speciation. What organisms eat is linked from their physiology of pheromone-controlled reproduction to biophysically constrained viral latency and all extant biodiversity via energy-dependent changes in base pairs and fixation of amino acid substitutions in the organized genomes of species from microbes to humans. See Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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