Model Organisms

From optoribogenetics to HelioRiboGenetics (1)

Optoribogenetic control of regulatory RNA molecules 9/24/20 “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Had he lived, Bruce S. McEwen probably would have received the 2020 Nobel Prize in Physiology or Medicine for linking God’s Creation of UV light and water from energy-as-information to biophysically constrained viral latency across kingdoms. McEwen et al., (1964) linked that heliocentric approach to scientific creationism…

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Optoribogenetic-driven sympatric speciation (1)

For presentation during session: Polycomb and chromatin remodeling Historical perspective: Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes… Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at…

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The microRNA-mediated fight against COVID-19 (1)

History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

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Coherently organized healthy longevity (1)

A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

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pH-dependent viral latency (6)

See first: pH-dependent viral latency (5) Researchers from Iran linked light-activated microRNA biogenesis in plants to the expression genes that effect the number, size and/or the pH of pathways that influence melanin synthesis in the context of human iris color and human skin pigmentation via the L‐tyrosine amino acid precursor. The claim on 6/5/20 by Frank M. LaFerla about the links from energy-dependent changes in microbes to humans and racism was retracted on the same day. Thank God, scientific Creationists…

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NIH’s ignorance: from roots to shoots (1)

A plant’s diet, surviving in a variable nutrient environment 3/3/20 links Algal ancestor of land plants was preadapted for symbiosis 10/5/15 from our NIH Director’s ridiculous claims about evolution across billions to millions of years to the fact that George M. Church has abandoned all hope for scientific progress that might otherwise have been achieved from follow-up on the Human Genome Project. See: Korean Genome Project: 1094 Korean personal genomes with clinical information 5/27/20 (with co-author George Church -Department of Genetics,…

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pH-dependent viral latency (4)

My top tweet @microRNApro during the month of March 2018 earned 3,884 impressions. I wrote: See also my series on “Interethnic biodiversity” via this search: Interethnic genetic simiarities and a PubMed search for microRNA See also: Denying Genetics Isn’t Shutting Down Racism, It’s Fueling It 3/30/18 On the male-female divide, for example, Reich cites profound differences, “reflecting more than 100 million years of evolution and adaptation.” On race, he is both agnostic about what we will eventually find out with respect…

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pH-dependent viral latency (2)

New vaccines protect against COVID-19 in non-human primates, study finds 5/20/20 See for comparison: Vaccines do not control pandemics (1) 5/15/20 I reiterate: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/18/18 Amino acid substitutions at these positions were found to be associated with an inability to serotype a strain and are responsible for antigenic changes48. Recently, amino acid substitutions in the three main antigenic regions, especially at positions 96…

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Vaccines do not control pandemics (1)

See: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/16/18 Compared to the G2 RotaTeq vaccine strain, 17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed. Amino acid changes control pandemics. Congo: MSF Ebola vaccination begins 5/30/18 The Ebola vaccine (rVSVDG-ZEBOV-GP) is being used as part of the overall strategy to control the Ebola outbreak. There was no indication that the vaccine strategy…

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The microRNA-mediated future of humanity (8)

The levels of complexity linked to the microRNA-mediated future of humanity can be examined by ages 10-14+ via game-play of: Bacillus (failed project) See instead: Function of miR825 and miR825* as Negative Regulators in Bacillus cereus AR156-elicited Systemic Resistance to Botrytis cinerea in Arabidopsis thaliana 10/17/19 Peptide Players compete to link amino acids to build a peptide chain (a fancy word for a protein). Virulence Players take on the role of viruses and compete to infect a host cell in…

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