Pharmacogenomics

RNAi 2002 to AI 2021 (4)

Happy New Year. Got SARS-Cov-2 or one of its synthetic mRNA vaccine-induced variants yet? SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes 12/28/21 …we unexpectedly discovered a viral miRNA-like small RNA, named CoV2-miR-O7a (for SARS-CoV-2 miRNA-like ORF7a-derived small RNA). Its abundance ranges from low to moderate as compared to host miRNAs and it associates with Argonaute proteins-core components of the RNA interference pathway. For a historical perspective on the role of microRNA-like small RNAs in viruses,…

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RNAi 2002 to AI 2021 (3)

See first: RNAi 2002 to AI 2021 (2) 12/30/21 The number of intelligent serious scientists who have integrated what is known about the physics, chemistry, and molecular biology of naturally occurring biophysically constrained microRNA-mediated viral endemicity and healthy longevity attests to the fact that most of them have been silenced. Indeed, in response to many of my Facebook Posts, Facebook claims: Independent fact-checkers investigate stories in a journalistic process meant to result in establishing the truth or falsity of the…

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RNAi 2002 to AI 2021 (1)

Summary: Intelligent serious scientists have linked energy-dependent RNA interference (RNAi) to all biodiversity on Earth. For comparison, biologically uninformed theorists have nothing but mathematical models and Artificial Intelligence (AI). Human pheromones: integrating neuroendocrinology and ethology  (2001) …the affect of pheromones on our emotions is linked to the effect of pheromones on the hormones of the hypothalamic-pituitary-gonadal axis –an unconscious affect. Based upon a detailed mammalian neuroendocrine model, Kohl [15] proposed that LH is the measurable link between sex and the…

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microRNA-mediated cures (10)

Merry Christmas 2021! Summary: microRNA-mediated cures for all virus-driven pathology have been linked from the 2002 Breakthrough of the Year: Small RNAs (12/19/02) to the 2021 Breakthrough of the year: Protein structures for all (12/16/21) via light-activated carbon fixation and biophysically constrained naturally-attenuated viral endemicity/latency in species from cyanobacteria to humans. As presciently predicted in Biblical Genesis, the physiology of pheromone-regulated genetic processes is required. That fact has been exemplified in at least 3 different patents, all of which attest…

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microRNA-mediated cures (7)

Pharmacogenomics: A road ahead for precision medicine in psychiatry 10/6/21 In this 2017 Precision Medicine Virtual Conference presentation, I linked the National Microbiome Initiative from microbial quorum sensing to the physiology of pheromone-regulated genetic processes of reproduction and endogenous RNA interference (#RNAi) via chromosomal rearrangements in flies from the works of Thomas Hunt Morgan (1910) to sympatric speciation across kingdoms. The chromosomal rearrangements link light-activated carbon fixation to the ATP-dependent creation of RNA and fixation of amino acid substitutions links…

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microRNA-mediated cures (3)

See first:  microRNA-mediated cures (2) For comparison to Genetic variations creating microRNA target sites…, and Nutrient-dependent/pheromone-controlled adaptive evolution, Masatoshi Nei claimed that nucleotide substitutions, insertion/deletion, segmental gene duplication, genomic duplication, changes in gene regulatory systems, transposition of genes, horizontal gene transfer et al., were mutations. Simply put, simple-minded theorists start with the idea that everything the happens to our supercoiled DNA is a mutation and they link mutations to evolution across billions to millions of years after energy-emerged from the…

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Naturally attenuated viral endemicity (8)

See first: Naturally attenuated viral endemicity (7) “MicroRNA-101-3p Modulates Mitochondrial Metabolism via the Regulation of Complex II Assembly 11/19/21 …we describe a new role for miR-101-3p as a modulator of mitochondrial metabolism via its regulation of multiple mitochondrial processes, including mtDNA transcription and complex II biogenesis.” See also: Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function 11/24/21 Exposure to long wavelength light (650–900 nm) in animals improves mitochondrial function, increasing ATP production and…

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God’s microRNA-mediated Creation of genotypes (9)

Watch for the 2021 Nobel Prize in Chemistry (10/6/21) to be linked from claims about the diet of moths and their physiology of reproduction to today’s resignation of NIH Director, Francis S. Collins, or to corruption among members of the Nobel Prize Committee. With few exceptions, awards in the “hard sciences” (Physics, Chemistry, Physiology and Medicine) link the light-activated proton motive force from the ATP-dependent Creation of microRNAs, RNA, and RNA interference to the pH-dependent physiology of reproduction across kingdoms…

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God’s microRNA-mediated Creation of genotypes (6)

microRNA 128,290 results. I was too busy to post links to articles when the total number of indexed publications hit 128,000. But see: Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis 9/30/21 These results indicate possible therapeutic use of stable anti-miR-24, albeit administered by other routes, in diseases that are alleviated by STING. miR-24 is known to affect brain development and fetal neuronal differentiation [69]; however these effects should have little bearing on…

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MicroRNA-mediated population control (4)

See first: MicroRNA-mediated population control (3) …nearly 125,000 indexed published works link peptide synthesis at the origin of life to visualizing a protonated RNA state that modulates microRNA-21 maturation to biophysically constrained viral latency and healthy longevity across kingdoms from microbes to mammals. See: microRNA There are now more than 125,000 indexed published works. The link from God’s Creation of energy-as-information to pH-dependent biophysically constrained viral latency and healthy longevity across kingdoms can be compared in the context of Characteristics…

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