Pharmacogenomics

Crimes against humanity (1)

From Michigan State University Ask the expert: What is Juneteenth? Historical Perspective: See: “Apology to People of Color for APA’s Role in Promoting, Perpetuating, and Failing to Challenge Racism, Racial Discrimination, and Human Hierarchy in U.S.” October 29, 2021 When will this historic apology be celebrated? Did you even know about it? Michigan State’s Richard Lenski still promotes the moronic theory that racial differences evolved from nutrient-dependent pheromone-regulated genetic processes of reproduction in E. coli. See: Experimental Test of the…

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Codon optimality vs systemic fraud (4)

A good model predicts. See: From Fertilization to Adult Sexual Behavior (1996). In our section on molecular epigenetics we predicted that A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins 6/16/22 would be linked to food energy and pheromone-regulated genetic processes of reproduction across kingdoms. On 6/23/22, that fact was placed back into the context of stupid theories. See: Abracadabra, One Becomes Two: The Importance of Context in Viral −1 Programmed Ribosomal Frameshifting  Yeast and potentially mammalian cells,…

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Polymathy changes society (1)

Is X-FILES relevant now… Did X-FILES predict the future? 6/9/22 (video) Science fiction author Greg Bear linked gene editing technology to the laboratory-based creation of a novel virus in his 2006 review published as “Quantico.” His claims about the existential threat were turned into a comedy routine by Jon Stewart. 6/1/07 (video) Former President Trump linked God’s Creation of sunlight and humidity to healthy longevity via KB Whaley’s polymathy when he claimed, albeit indirectly, that pH-dependent microRNA-mediated protein folding chemistry…

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Codon optimality vs systemic fraud (3)

A system of fraud exists that fails to link natural selection for energy-dependent codon optimality to The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents 5/17/22 This article belongs to the Special Issue Molecular Effects of Phytochemicals on Cholesterol Metabolism Genes Collectively, everything known to intelligent serious scientists about cell type differentiation across kingdoms can be linked from An Expanded Landscape of Unusually Short RNAs in 11 Samples…

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Codon optimality vs systemic fraud (2)

See first: Codon optimality vs systemic fraud (1) Researchers identified over 5,500 new viruses in the ocean, including a missing link in viral evolution 4/8/22 and Ocean water samples yield treasure trove of RNA virus data 4/8/22 attest to facts about the Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20 that link God’s ATP-dependent Creation of RNA from RNA-peptide interactions at the origin of life to the Mapping and characterization of structural variation in 17,795…

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Epistemic corruption (10)

Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly 5/26/22 Full functional evaluation of the recombinant key enzymes in vivo and in vitro, individually and in concert, provided in-depth mechanistic insights into a streamlined C–C bond-forming cascade that involves installation of compatible reactivity at seemingly unreactive Cα positions of amino acid precursors. Our work extends the biosynthetic and biocatalytic toolbox for γ-butyrolactone formation, provides a general paradigm for furanolide biosynthesis and sets the stage for their targeted discovery, biosynthetic…

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Epistemic corruption (9)

A prebiotically plausible scenario of an RNA–peptide world was reported in Science Magazine by Robert F. Service. See: How life could have arisen on an ‘RNA world’ 5/11/22 New evidence suggests RNA and peptides may have helped build each other on early Earth Researchers who study the origin of life have long considered RNA the central player because it can both carry genetic information and catalyze necessary chemical reactions. It was likely present on our planet before life evolved. But…

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Epistemic corruption (5)

This is a false claim Bacterial species rarely work together  5/5/22 See this placard from the US Department of the Interior’s National Park Service for comparison: Cyanobacteria were once called blue-green algae. Light-activated carbon fixation in cyanobacteria links their color from microRNA-mediated protein folding chemistry to protection from the virus-driven degradation of messenger RNA (mRNA). The protection of organized genomes from viruses has been linked to constraints on all virus-driven pathology across kingdoms via this patent for RNA interference, which…

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Epistemic corruption (4)

Link opens the CDC’s page on: Cyanobacteria, also called blue-green algae, are microscopic organisms found naturally in all types of water. These single-celled organisms live in fresh, brackish (combined salt and fresh water), and marine water. These organisms use sunlight to make their own food. Acting NIH Director Admits Appearance Of Conflict Of Interest In Secret Royalty Payments To Fauci, Scientists 5/11/22 Collins received 14 payments, Fauci received 23 payments… There is no better example of this than the third-party…

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MicroRNA-mediated existential threats (8)

Summary: Natural processes link light-activated microRNA biogenesis to pH-dependent prevention of viral infections. The natural processes are energy-dependent and biophysically constrained by the pheromone-regulated genetic processes of reproduction across kingdoms from microbes to humans. Follow me @microRNApro on Twitter if you want to help others prevent virus-driven existential threats to humanity. See also: MicroRNA.pro, http://Autophagy.pro & continue to follow me on http://RNA-mediated.com as I link God’s Creation of subatomic particles from pH-dependent peptide synthesis to sympatric speciation and healthy ecosystems…

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