Pharmacogenomics

The microRNA-mediated fight against COVID-19 (1)

History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

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Vaccines do not control pandemics (1)

See: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/16/18 Compared to the G2 RotaTeq vaccine strain, 17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed. Amino acid changes control pandemics. Congo: MSF Ebola vaccination begins 5/30/18 The Ebola vaccine (rVSVDG-ZEBOV-GP) is being used as part of the overall strategy to control the Ebola outbreak. There was no indication that the vaccine strategy…

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The microRNA-mediated future of humanity (8)

The levels of complexity linked to the microRNA-mediated future of humanity can be examined by ages 10-14+ via game-play of: Bacillus (failed project) See instead: Function of miR825 and miR825* as Negative Regulators in Bacillus cereus AR156-elicited Systemic Resistance to Botrytis cinerea in Arabidopsis thaliana 10/17/19 Peptide Players compete to link amino acids to build a peptide chain (a fancy word for a protein). Virulence Players take on the role of viruses and compete to infect a host cell in…

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The microRNA-mediated future of humanity (3)

Light-activated microRNA biogenesis has been linked from the pheromone-controlled physiology of reproduction to healthy longevity via protection from the virus-driven degradation of messenger RNA in all living genera. On 4/21/20 that fact was misrepresented as: Coronavirus has mutated into at least 30 different strains, Chinese study finds. The report was based on this non-peer-reviewed paper Patient-derived mutations impact pathogenicity of SARS-CoV-2 We observed intrapersonal variation and 6 different mutations in the spike glycoprotein (S protein), including 2 different SNVs that…

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WHO’s ignorance: From roots to shoots (2)

WHO’s ignorance: From roots to shoots (1) Amino acid substitutions within or near the active site of the viral neuraminidase (NA) may affect influenza virus fitness. See: Neuraminidase inhibitor susceptibility and neuraminidase enzyme kinetics of human influenza A and B viruses circulating in Thailand in 2010–2015  The authors cite the World Health Organization’s Summary of neuraminidase amino acid substitutions associated with reduced inhibition by neuraminidase inhibitors” The summary is available as a pdf download. See also: Viral Factors Associated With…

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Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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An evolutionary theory killer

Epigenetic inheritance of spatiotemporal regulation (5)

Thanks for the Stress, Dad As embryos, the researchers found that the mouse offspring, which exhibited more anxious behavior than usual, also had lower miRNA levels, as did the sperm of the male offspring upon maturity. The stress-linked degradation of messenger RNA is caused by virus-driven energy theft, which has been linked to all pathology in species from bacteria to humans.  For example: Neutrons identify critical details in bacterial enzyme implicated in gastric cancer Ronning’s team focused on H. pylori’s…

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From photons to the proton motive force (2)

If you know someone who has linked differences in the energy of photons from the proton motive force to the physiology of reproduction and all biophysically constrained biodiversity, ask if they will attend Schrödinger at 75-The Future of Biology For contrast, touting genetic evolution is not the future of biology. See: Abstract: K06.00013 : A Path Integral Method for Analytically Tractable Inference of Evolutionary Dynamics Understanding the forces that shape genetic evolution is a subject of fundamental importance in biology…

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From photons to the proton motive force (1)

Conclusion: If you would like to learn how to link quantized energy-dependent changes in atoms to ecosystems in all living genera via the physiology of reproduction, join others age 10+ who will be playing this game in September 2018. Fly’s Blood-Brain Barrier Has Circadian Rhythms “the anatomic characteristics of insect and vertebrate BBB structures are quite distinct.” The molecular mechanisms are conserved. My comment to The Scientist: Feedback of the Drosophila period gene product on circadian cycling of its messenger…

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Light-activated carbon fixation did not evolve (4)

Summary: Dobzhansky was joking about the time it would take for the creation of light to cause the energy-dependent fixation of RNA-mediated amino acid substitutions, which link food energy to the creation of enyzmes that metabolized food. His joke extends from the creation of sunlight — as the “light of evolution” — to the species-specific pheromone-controlled physiology of reproduction and cell type differentiation in chimpanzees and humans compared to gorillas via one amino acid substitution. The joke was played on…

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