Pharmacogenomics

RNA-mediated silencing (9)

April 9, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
No Comments

WHO, the World Health Organization, thought you wouldn’t notice that your organizations were infiltrated by entitled feminists and stupid conspiracy theorists. See: Skirting the Matter of Feminism’s Culpability 4/4/22 “…true to feminist form, shifts to men and misogyny the blame for the epistemological collapse occurring in liberal democracies while ignoring the real culprit, feminism.” See also: RNA-mediated silencing (7) Three of the 4 articles that linked light-activated carbon fixation in cyanobacteria from microRNA-mediated protein folding chemistry across kingdoms were published…

Read More

RNA-mediated silencing (8)

April 1, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
No Comments

Now fully complete, human genome reveals new secrets 3/31/22 reports on: A next-generation human genome sequence 3/31/22 From telomere to telomere: The transcriptional and epigenetic state of human repeat elements 4/1/22 The complete sequence of a human genome 4/1/22 Epigenetic patterns in a complete human genome 4/1/22 Complete genomic and epigenetic maps of human centromeres 4/1/22 The articles and the reporting obfuscate the fact that God’s Creation of energy-as-information links sunlight and humidity to His Creation of all biodiversity on…

Read More

RNA-mediated silencing (4)

March 21, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
One Comment

Angel Trumpets are extinct in the wild. Daffodils are extremely well adapted. Other organisms and people who are not ecologically adapted suffer unnecessarily and die prematurely from the virus-driven degradation of mRNA. They do not evolve into different species. See first: RNA-mediated silencing (3) Robert H. Singer, co-authored: Single-molecule imaging of microRNA-mediated gene silencing in cells 3/17/22 Simultaneous visualization of single mRNAs, translation, and miRNA-binding revealed that miRNAs preferentially bind to translated mRNAs rather than untranslated mRNAs. Among other positions,…

Read More

RNA-mediated silencing (2)

March 14, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
No Comments

Transcriptional and post-transcriptional control of epithelial-mesenchymal plasticity: why so many regulators? 3/12/22 God’s Creation of sunlight and humidity at the origin of life ~6000 years ago links light-activated carbon fixation in cyanobacteria to microRNA-mediated protein folding chemistry and healthy longevity across kingdoms via the number of regulators. Fixation of amino acid substitutions is the link to viral endemicity. The facts are clear in: Cellulose: A Plant Cell Biology Game , a STEM toy for ages 14+, which links God’s Creation…

Read More

microRNA-mediated biodiversity (9)

February 20, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
No Comments

microRNA (miR-KT-635) encoded by Cyprinid herpesvirus 2 regulates the viral replication with targeting to the ORF23 (2/19/22) has been linked to the patented cure for all virus-driven diseases across kingdoms via Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency (2/8/22) Who, besides our NIH Director, Lawrence A. Tabak and former President Trump is not surprised to see that researchers from Harvard collaborated with researchers from China to obfuscate the facts from the patent for…

Read More

microRNA-mediated biodiversity (2)

February 3, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
No Comments

From microRNA-mediated biodiversity (1) See for comparison my blog posts that mention: glycine, which start with Epigenetic regulation of aging by glycine and GnRH 5/26/15 The focus here is on vertebrates, but the conserved molecular mechanisms extend across all species. Who else is watching science journalist John Hewitt continue on his collision course with reality? In Myelin is a gift from retroviruses 2/1/22, he again fails to link light-activated carbon fixation in cyanobacteria to biophysically constrained naturally attenuated viral endemicity…

Read More

RNAi 2002 to AI 2021 (4)

December 31, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
No Comments

Happy New Year. Got SARS-Cov-2 or one of its synthetic mRNA vaccine-induced variants yet? SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes 12/28/21 …we unexpectedly discovered a viral miRNA-like small RNA, named CoV2-miR-O7a (for SARS-CoV-2 miRNA-like ORF7a-derived small RNA). Its abundance ranges from low to moderate as compared to host miRNAs and it associates with Argonaute proteins-core components of the RNA interference pathway. For a historical perspective on the role of microRNA-like small RNAs in viruses,…

Read More

RNAi 2002 to AI 2021 (3)

December 30, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA–Mediated Epigenetic Heredity
No Comments

See first: RNAi 2002 to AI 2021 (2) 12/30/21 The number of intelligent serious scientists who have integrated what is known about the physics, chemistry, and molecular biology of naturally occurring biophysically constrained microRNA-mediated viral endemicity and healthy longevity attests to the fact that most of them have been silenced. Indeed, in response to many of my Facebook Posts, Facebook claims: Independent fact-checkers investigate stories in a journalistic process meant to result in establishing the truth or falsity of the…

Read More

RNAi 2002 to AI 2021 (1)

December 29, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity
No Comments

Summary: Intelligent serious scientists have linked energy-dependent RNA interference (RNAi) to all biodiversity on Earth. For comparison, biologically uninformed theorists have nothing but mathematical models and Artificial Intelligence (AI). Human pheromones: integrating neuroendocrinology and ethology  (2001) …the affect of pheromones on our emotions is linked to the effect of pheromones on the hormones of the hypothalamic-pituitary-gonadal axis –an unconscious affect. Based upon a detailed mammalian neuroendocrine model, Kohl [15] proposed that LH is the measurable link between sex and the…

Read More

microRNA-mediated cures (10)

December 25, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
No Comments

Merry Christmas 2021! Summary: microRNA-mediated cures for all virus-driven pathology have been linked from the 2002 Breakthrough of the Year: Small RNAs (12/19/02) to the 2021 Breakthrough of the year: Protein structures for all (12/16/21) via light-activated carbon fixation and biophysically constrained naturally-attenuated viral endemicity/latency in species from cyanobacteria to humans. As presciently predicted in Biblical Genesis, the physiology of pheromone-regulated genetic processes is required. That fact has been exemplified in at least 3 different patents, all of which attest…

Read More
RSS Perfuming the Mind