Combating Evolution to Fight Disease “…an important gap is being filled by molecular understanding of the genesis of variation that confers the ability to evolve.” Inside the drive to collect DNA from 1 million veterans and revolutionize medicine Excerpt 1) The U.S. Department of Veterans Affairs is gathering blood from 1 million veterans to sequence … Can veterans and other prisoners escape pseudoscience?
Unraveling the Secrets of DNA Excerpt: Belmont’s team will “rewire” chromosome regions to different nuclear locations and then determine the functional consequences of this rewiring. My comment: The “rewiring” can be placed into the context of nutrient-dependent pheromone-controlled rewiring of the genome that led to a report of over-the-weekend” re-evolution of the bacterial flagellum. Two … Unraveling the secrets of RNA-mediated events
It’s Not Brain Surgery, Ben Carson Excerpt: …“Heal Inspire Revive,” invokes an image of him pounding on the chest of a pulseless America. Whether or not he actually knows how to handle a crash cart of that size, many voters don’t seem to doubt that he can. And he doesn’t doubt it either. My comment: … Skip the politics; embrace the facts
FREE* SAMPLE Histone Modification Antibodies See also — as used in ad copy excerpt for their products: Histone modification antibodies are notorious for binding non-specifically to similar, but off-target histone modifications and/or having their specific binding inhibited by steric hindrance from modifications on neighboring residues. CST addresses these issues by using including a peptide … FREE* SAMPLE: Histone modification
Analysis of 5′ gene regions reveals extraordinary conservation of novel non-coding sequences in a wide range of animals Conclusion: It is our hope that each and every one of these regions will make interesting candidates for experimental analysis, helping to increase our understanding of regulation of gene expression, and particularly our understanding of regulatory elements … 700 million years of evolution?
Retrotransposons (also called transposons via RNA intermediates) are genetic elements that can amplify themselves in a genome and are ubiquitous components of the DNA of many eukaryotic organisms. See also: A Single Amino Acid Change in the Yeast Retrotransposon Ty5 Abolishes Targeting to Silent Chromatin Excerpt: Target site biases observed among retroviruses and retrotransposons are … RNA-mediated retrotransposon-mediated biodiversity
Sperm RNAs Transmit Stress Re: Bale’s group will next try to identify epigenetic changes in embryos that might allow miRNA changes to have an effect in adult animals. Nutrient-dependent microRNAs are the link from viral microRNAs to transgenerational epigenetic inheritance of morphological and behavioral phenotypes. The nutrient-dependent microRNAs typically protect organized genomes from DNA damage … Epigenetic inheritance of stress-perturbed protein folding
Sex Differences in the Brain (revisited) A comment that was complementary led me to add this: Ideas about evolutionary processes that automagically led to sex differences in cell types can be dissmissed in the light of experimental evidence of biologically-based cause and effect. Since 1996, for example, serious scientists have known about the role of … Xist-ing on planet Earth
Tethering Transposons Excerpt: Transposons—thought to be related to viruses—can copy themselves and insert randomly around the genome. A paper published today (October 15) in Science provides a greater understanding of how cells shut down these rogue jumping genes. My comment: Shouldn’t someone else be claiming that nutrient-dependent microRNAs prevent the accumulation of viral microRNAs that leads … Preventing genomic entropy
Brains work via their genes just as much as their neurons Excerpt 1) Genes direct the production of the above-mentioned brain molecules via intermediaries made of RNA. RNA molecules tell the machinery of the cell when and how to make the proteins it needs to grow and function. Excerpt 2) This reciprocity between genes and … The Current State of Neuroscience
