Pharmacogenomics

RNA-mediated silencing (10)

Stopping pandemics before they start: Lessons learned from SARS-CoV-2 3/11/22 The impact of COVID-19 on human health in 2020 alone was estimated to be estimated  to cost more than $2 trillion. Light-activated pH-dependent carbon fixation in cyanobacteria and microRNA-mediated protein folding chemistry clearly link the potential of hydrogen (pH) to all biodiversity on Earth via RNA-mediated silencing (10)

RNA-mediated silencing (9)

WHO, the World Health Organization, thought you wouldn’t notice that your organizations were infiltrated by entitled feminists and stupid conspiracy theorists. See: Skirting the Matter of Feminism’s Culpability 4/4/22 “…true to feminist form, shifts to men and misogyny the blame for the epistemological collapse occurring in liberal democracies while ignoring the real culprit, feminism.” See RNA-mediated silencing (9)

RNA-mediated silencing (8)

Now fully complete, human genome reveals new secrets 3/31/22 reports on: A next-generation human genome sequence 3/31/22 From telomere to telomere: The transcriptional and epigenetic state of human repeat elements 4/1/22 The complete sequence of a human genome 4/1/22 Epigenetic patterns in a complete human genome 4/1/22 Complete genomic and epigenetic maps of human centromeres RNA-mediated silencing (8)

RNA-mediated silencing (4)

Angel Trumpets are extinct in the wild. Daffodils are extremely well adapted. Other organisms and people who are not ecologically adapted suffer unnecessarily and die prematurely from the virus-driven degradation of mRNA. They do not evolve into different species. See first: RNA-mediated silencing (3) Robert H. Singer, co-authored: Single-molecule imaging of microRNA-mediated gene silencing in RNA-mediated silencing (4)

RNA-mediated silencing (2)

Transcriptional and post-transcriptional control of epithelial-mesenchymal plasticity: why so many regulators? 3/12/22 God’s Creation of sunlight and humidity at the origin of life ~6000 years ago links light-activated carbon fixation in cyanobacteria to microRNA-mediated protein folding chemistry and healthy longevity across kingdoms via the number of regulators. Fixation of amino acid substitutions is the link RNA-mediated silencing (2)

microRNA-mediated biodiversity (9)

microRNA (miR-KT-635) encoded by Cyprinid herpesvirus 2 regulates the viral replication with targeting to the ORF23 (2/19/22) has been linked to the patented cure for all virus-driven diseases across kingdoms via Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency (2/8/22) Who, besides our NIH Director, Lawrence A. Tabak and microRNA-mediated biodiversity (9)

microRNA-mediated biodiversity (2)

From microRNA-mediated biodiversity (1) See for comparison my blog posts that mention: glycine, which start with Epigenetic regulation of aging by glycine and GnRH 5/26/15 The focus here is on vertebrates, but the conserved molecular mechanisms extend across all species. Who else is watching science journalist John Hewitt continue on his collision course with reality? microRNA-mediated biodiversity (2)

RNAi 2002 to AI 2021 (4)

Happy New Year. Got SARS-Cov-2 or one of its synthetic mRNA vaccine-induced variants yet? SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes 12/28/21 …we unexpectedly discovered a viral miRNA-like small RNA, named CoV2-miR-O7a (for SARS-CoV-2 miRNA-like ORF7a-derived small RNA). Its abundance ranges from low to moderate as compared to host miRNAs RNAi 2002 to AI 2021 (4)

RNAi 2002 to AI 2021 (3)

See first: RNAi 2002 to AI 2021 (2) 12/30/21 The number of intelligent serious scientists who have integrated what is known about the physics, chemistry, and molecular biology of naturally occurring biophysically constrained microRNA-mediated viral endemicity and healthy longevity attests to the fact that most of them have been silenced. Indeed, in response to many RNAi 2002 to AI 2021 (3)

RNAi 2002 to AI 2021 (1)

Summary: Intelligent serious scientists have linked energy-dependent RNA interference (RNAi) to all biodiversity on Earth. For comparison, biologically uninformed theorists have nothing but mathematical models and Artificial Intelligence (AI). Human pheromones: integrating neuroendocrinology and ethology  (2001) …the affect of pheromones on our emotions is linked to the effect of pheromones on the hormones of the RNAi 2002 to AI 2021 (1)