Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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Quantum initiation of cold chemistry vs Hypeology (3)

See: Quantum initiation of cold chemistry vs Hypeology (2) Facts about the quantized energy-dependent creation of reverse transcriptase, an enzyme that converts a sequence in an RNA molecule into a sequence in a DNA molecule, have been placed into the context of social organization. Social organization: The thermodynamic basis The objective of this work is to establish the connection between energy engineering and social organization and to bring social organization under the big tent of physics. Reported as: How physics…

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NHEJ disruption and HDR correction?

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop is being held in Park Inn by Radisson Pulkovskaya Hotel & Conference Centre St Petersburg, Saint-Petersburg, Russia, September 2-7 2018. We will discuss all aspects…

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An evolutionary theory killer

Cardiac energy metabolism requires units of energy

Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism (First published May 17, 2018 ) Silencing the mRNA of general control of amino acid synthesis 5-like protein 1 reduced acetylation of LCAD and βHAD as well as fatty acid oxidation rates in cardiomyocytes. Thus, hypertrophy in CHDs prevents the postnatal increase in myocardial acetylation, resulting in a delayed maturation of cardiac fatty acid oxidation. The virus-driven theft of quantized energy causes the silencing of mRNA, which generally controls amino…

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An evolutionary theory killer

Quantum initiation of cold chemistry vs Hypeology (1)

Cold chemistry with two atoms Summary For centuries, chemists have written equations representing chemical reactions by using symbols for atoms and molecules; for example, 2H2O + 2Na → 2NaOH + H2. This short notation shows only four reacting particles, but even in a classroom demonstration where a small piece of sodium is dropped in water, the total number of reactants will be on the order of Avogadro’s number (∼6 × 1023). On page 900 of this issue, Liu et al.…

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Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

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Laws of biology vs no laws of physics

There Are No Laws of Physics. There’s Only the Landscape In Einstein’s view, if we probed the essence of physics deeply enough, there would be one and only one way in which all the components — matter, radiation, forces, space and time — would fit together to make reality work, just as the gears, springs, dials and wheels of a mechanical clock uniquely combine to keep time. Reported as:  Physicist concludes there are no laws of physics It was June…

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MicroRNA-mediated alternative splicing (revisited)

Building one molecule from a reservoir of two atoms reported as: Cold chemistry with two atoms. They linked differences in the energy of photons from two different wavelengths of light, 700 nm and 976 nm, to the creation of the molecule NaCs*. They were able to detect molecule formation in the context of atom loss and NaCs* vibrational levels near the dissociation threshold. Detecting resonances that have not been previously observed appears to be the link from quantum physics to…

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Corporate owned microRNA-mediated biodiversity

Corporate control and global governance of marine genetic resources Who owns ocean biodiversity? All biodiversity is quantized energy-dependent and RNA-mediated in the context of the physiology of reproduction and pheromone-controlled RNA interference (RNAi) . Naturally occurring light-activated RNAi ensures viral latency, which helps to ensure healthy longevity. George Church et al, own this patent on RNA interference, which suggests that he and others own all biodiversity in the context of the Virus-mediated archaeal hecatomb in the deep seafloor and patent…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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