Laws of Biology / Rules of Life

Summary: Slide number 6 clearly states the “Levels of Biological Organization” that the “NSF’s 10 Big Ideas” finally places into the context of what has been known to all serious scientists for more than a century. Simply put, Hugo de Vries definition of mutation (sudden energy jumps) should never have been accepted as anything besides the claim of a biologically uninformed science idiot. Instead, the definition bastardized every aspect of what is now known about biophysically constrained viral latency and…

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NSF’s parrot and other parrots

Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) “Isolated thymus nuclei transport amino acids into an intranuclear pool by a process which seems to depend on energy from nuclear ATP synthesis (20).” The energy must be biophysically constrained: Long-range coherence and energy storage in biological systems (1968) Human Pheromones: Linking Neuroendocrinology and Ethology (revisited) (2010) Slide # 6 attests to the fact that the levels of biological organization…

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Less evolvable RNA-mediated ecological adaptations

No experimental evidence of biophysically constrained RNA-mediated cell type differentiation supports the claim about “…the evolutionary plasticity of the regulatory regions involved in transcriptional regulation…” The overwhelming systems complexity of energy-dependent RNA-mediated cause and effect can no longer be placed into the context of the pseudoscientific nonsense touted by theorists. Watch Andrea Wagner’s group try to escape from the claims made by losers. But first see: Kalevi Kull: Censorship & Royal Society Evo Event Nobody wants to belong to the…

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Let there be anti-entropic virucidal light

Summary: This is a lie! …theories are too detailed to be included in models that study host-phage interactions in the long term, which hinders our understanding of systems that range from pathogens infecting gut bacteria to marine phage shaping present and future oceans. Fuelling the future In his short story ‘Let There Be Light’, the science-fiction author Robert A Heinlein introduced the energy source that would power his Future History series of stories and novels. In The Darwin Code, Greg…

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Psychophysical Laws of Biology: RNA-mediated nutritional psychiatry (3)

Psychophysical Laws and the Superorganism  (open access) …superorganisms may also exhibit such behaviour, suggesting that these laws arise from fundamental mechanisms of information processing and decision-making. Reported on Jun 14, 2013 as Nutrient-dependent/pheromone-controlled adaptive evolution: a model and again on: Mar 27, 2018 as Honeybees may unlock the secrets of how the human brain works The study… found that superorganisms may obey the same laws as the human brain. Kohl’s “Laws of Biology” and Darwin’s “conditions of life” can now be…

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Odor activation of ATP (2)

Metabolic Regulation of Cytoplasmic DNA Synthesis (1974) The curve that results when the rate of DNA synthesis is plotted as a function of ATP concentration is sigmoidal, suggesting that more than one site on the enzyme interacts with ATP and that these sites are acting cooperatively. Odor activation of ATP is the obvious link to RNA-mediated feedback loops that control the food energy-dependent pheromone-controlled physiology of reproduction via the rate of DNA repair in species from microbes to humans. See:…

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Part 3: Light-controlled cell biology (revisited)

Your cells are constantly being shed and replaced—so is your body ever completely refreshed? Does anything remain of the body that existed on Jan. 1, 2017? 2007? The day you were born? (video) Out of Order: Undaunted  …as I prepared for this issue’s Special Report on Microbiomics (starting on page 19), I am stunned by what I am only starting to understand. That our individual existence as humans may only be 10 percent of what we see in the mirror—and…

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Light-controlled cell biology (revisited)

See Sci-Bay Scholar for citations and downloads of more than 3300 published works that link viruses to microRNAs Summary: …either the organized genomes of all cell types use the energy source, or viruses use the biophysically constrained energy of the cell types. No extant species can be used as an example of how the virus-driven theft of quantized energy can be linked from natural selection to the evolution of a new species. See also, with my emphasis: Light Offers New…

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MicroRNA-activated / RNA-mediated gene expression

Summary: All patterns exist only in the context of the de novo creation of  enzymes and energy-dependent microRNAs that link light-activated endogenous substrates from what is known about particle physics to biophysically constrained viral latency in the cell biology game: Cytosis. See also: miRNA activation is an endogenous gene expression pathway Moving forward: Few people are likely to ask about the origin (i.e., the de novo creation) of energy-dependent microRNAs. Fewer still will link the creation of quantized energy as…

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Death cures theorist’s Amyotrophic Lateral Sclerosis (ALS).

Stephen Hawking death: Was he the smartest man in the world? The media need superheroes in science just as in every sphere of life, but there is really a continuous range of abilities with no clear dividing line. For comparison: Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS) A pathogenic mutation in D-amino acid oxidase (DAO) associated with familial ALS impairs D-serine metabolism and causes protein aggregation, autophagy and cell death…

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