replication timing

microRNA-mediated biodiversity (6)

Tell me if you know a paleontologist or any other stupid theorist who is willing to discuss facts that link “Lessons from microRNA biology: Top key cellular drivers of Autosomal Dominant Polycystic Kidney Disease  to “… better understanding [of] the key processes resulting in pathophysiological changes that underlie disease.” Most theorists, especially paleontologists, seem willing to keep the diseases and their theories that link the virus-driven degradation of messenger RNA to the fossil record via extinctions and the Flood in…

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microRNA-mediated biodiversity (5)

Criticisms of the nutrient-dependent pheromone-controlled evolutionary model 6/4/14 Editor’s note The 2013 review article by James Vaughn Kohl published in Socioaffective Neuroscience & Psychology and criticized in the above Letter to the Editor was subjected to standard peer review and the revised version was accepted by me after it had been accepted by both reviewers. Neo-Darwinian theorists still seem to think there is room for debate about the fact that nutrient stress and social stress have been linked to all…

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microRNA-mediated biodiversity (3)

See first: The tipping point (revisited): 135K Conclusion: Eating food, for example, is the required link to ecological adaptations. See also: Museum für Naturkunde Explores Maria Sibylla Merian’s Legacy and Editions of Her Metamorphosis The Wondrous Transformation of Caterpillars and their Remarkable Diet of Flowers Moving forward: Fixation of amino acid substitutions in organized primate genomes is food energy-dependent. Pheromone-regulated genetic processes of reproduction link the fixation of the amino acid substitutions to sympatric speciation across kingdoms. This is how…

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The tipping point (revisited): 135K

The tipping point (revisited): 110K (2) 10/22/20 Excerpt …seem to believe that President Trump’s claims about UV light and humidity have not been linked from the end of the COVID-19 nonsense to the end of their party, the end of Communism, the end of atheism, the end of racism and the end of all the liberal BS. Is the link from God’s Creation of UV light and water to ATP-dependent oxidative phosphorylation not perfectly clear to all intelligent people? I…

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microRNA-mediated biodiversity (2)

From microRNA-mediated biodiversity (1) See for comparison my blog posts that mention: glycine, which start with Epigenetic regulation of aging by glycine and GnRH 5/26/15 The focus here is on vertebrates, but the conserved molecular mechanisms extend across all species. Who else is watching science journalist John Hewitt continue on his collision course with reality? In Myelin is a gift from retroviruses 2/1/22, he again fails to link light-activated carbon fixation in cyanobacteria to biophysically constrained naturally attenuated viral endemicity…

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microRNA-mediated biodiversity (1)

I started this series to show biologically uninformed evolutionary theorist that all intelligent serious scientists know how stupid the theorists have always been A clinical and in-silico study of MicroRNA-21 and growth differentiation factor-15 expression in pre-diabetes, type 2 diabetes and diabetic nephropathy 2/1/22 RESULTS: MicroRNA-21 was found to directly target GDF15 downregulating transcription factors KLF4, TP53, and CEBPB. A significant difference in the levels of serum GDF15 was observed in Pre-diabetes (708.56 ±76.37), T2DM (1528.87 ±140.75) and DN patients…

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“The Darwin Code: Intelligent Design without God” (4)

De novo mutation rates at the single-mutation resolution in a human HBB gene-region associated with adaptation and genetic disease, published by Cold Springs Harbor Laboratory Press, was reported as Study uncovers first evidence of long-term directionality in origination of human mutation, challenging neo-Darwinism  1/31/22 Directionality is energy-dependent. If this was the first study of long-term energy-dependent directionality, how did Greg Bear get so far ahead of the evidence on energy-dependent biophysically constrained human endogenous retroviruses (HERVs) via “…the treatment afforded…

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“The Darwin Code: Intelligent Design without God” (3)

Are we living in a baby universe that looks like a black hole to outsiders? If the black holes that form in our cosmos give birth to baby Universes, perhaps we arose from the formation of a black hole ourselves. — Ethan Siegel See for comparison: Focus on Structure to Verify Protein Function (free download) All intelligent serious scientists have linked God’s Creation of sunlight and humidity to His Creation of all biomass on Earth and protection from the virus-driven…

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RNAi 2002 to AI 2021 (10)

The 6-part series on Energy-dependent epigenetic translation to mRNA stability that ran here between 5/12/17 and 5/22/17 predictably links facts about energy-dependent microRNA-mediated chromosomal inheritance to the end of all the stupid theories that were touted by Gene Levinson in Rethinking Evolution: The Revolution That’s Hiding in Plain Sight (2021) See first: RNAi 2002 to AI 2021 (8) Light-activated microRNA biogenesis obviously links God’s energy-dependent Creation of the cell wall across kingdoms via: Biogenesis and Mechanisms of miRNA-Mediated Gene Regulation…

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RNAi 2002 to AI 2021 (6)

Gene Levinson’s Rethinking Evolution: The Revolution That’s Hiding in Plain Sight exemplifies the epic failure of many biologically uninformed theorists who appear to know nothing about energy-dependent microRNA-mediated stem cell creation. See an example of his lessons at The Fruits of the Molecular Genetics Revolution. Daily Lesson 148 from “Rethinking Evolution.” 7/8/21 Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual…

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