RNA-directed DNA methylation

Virus-driven sex differences?

DNA methylation on N6-adenine in mammalian embryonic stem cells Excerpt: DNA methylation is a crucial component of epigenetic regulation that controls many important aspects of mammalian biology, such as imprinting, X chromosome inactivation and tumorigenesis1, 2. My comment: Nutrient-dependent RNA-directed DNA methylation links RNA-mediated amino acid substitutions to protein folding chemistry during thermodynamic cycles of energy dependent protein biosynthesis and degradation. Sex of a baby? Ancient virus makes the call Excerpt: …in other organisms, such as C elegans and the…

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Ricki Lewis’ Time Machine (4)

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan Excerpt: The signal we observe is driven by rs429358, a non-synonymous Cys112Arg variant, which defines the ε4 allele and which has not previously been shown to be the causal variant influencing lifespan. See also: Gorilla Genome 2.0: Lessons for the Clinic? Excerpt: VARIANTS OF UNCERTAIN SIGNIFICANCE With phrases such as “settled science” and “scientific proof” part of the lexicon, it’s little wonder that health care consumers expect…

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Creating and/or programming the immune system

A programming language for living cells Thanks to Fabricio Paes de Medeiros for calling attention to this example of an engineered innate immune system. The immune system links the epigenetic landscape to the physical landscape of supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. Excerpt: The sensors can detect different compounds, such as oxygen or glucose, as well as light, temperature, acidity, and other environmental conditions. My comment: It will be interesting to see…

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Half truths support theories without facts

How to lie by telling the truth Excerpt: People… trot out half-truths, in full expectation and knowledge that they will create a false impression. And then, when others act on the false impression, the “truth-telling liars” can sit back and pretend that they aren’t liars. They get the benefit of lying, without any damage to their precious self-image. My comment: It is more difficult for others to determine who benefits from half truths when more than one individual or research…

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YEC compared to Perry Marshall’s opinions

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos Received: June 9, 2015/ Published: March 24, 2016 Conclusion: In conclusion, we suggest that highly heterogeneous expression of several Oct4 and/or Sox2 targets within the 4-cell embryo, regulated by differential activity of CARM1, creates heterogeneities that bias cell fate toward either an embryonic (pluripotent) or extra-embryonic (differentiating) fate. We further suggest that the highly heterogeneous expression of Sox21 is one of a number of mechanisms available to…

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Creating nutrient-dependent life with enough genes to survive (2)

See also: Creating nutrient-dependent life with enough genes to survive Minimal Genome Created Excerpt 1) “In biology, as we’ve been trying to do genetic and biological engineering, we’re frustrated by the fact that . . . evolution has given us a real mess—it’s really just bubble gum and sticks, piecing together whatever works,” said biomedical engineer Chris Voigt of MIT who was not involved in the study. “This [work] is one of the first attempts at a grand scale to…

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Confusing effects and affects of visual input

Their report indicates that these researchers never learned to differentiate between epigenetic effects on RNA-mediated cell type differentiation compared to the experience-dependent affects on behavior of amino acid substitutions. Experience Affects Critical Period Plasticity in the Visual Cortex through an Epigenetic Regulation of Histone Post-Translational Modifications Excerpt: We show that the early exposure of rat pups to enriching environmental conditions accelerates the critical period for plasticity in the primary visual cortex, linking this effect to increased histone acetylation, specifically at…

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Nutrient-dependent life vs virus-driven pathology

Young Earth Creationists killing Christian credibility? Perry Marshall says: March 19, 2016 at 10:04 am James, you are one step away from being banned because of your disingenuous comments, your accusations, and your unnecessary combativeness. I am getting tired of it. People accuse you of being a troll for a reason. This is your final warning. My comment: Thanks for the warning, Perry Marshall. People who do not like me to disseminate accurate information about biologically-based cause and effect accuse…

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Selective reporting of inferences: examples of pseudoscience

In the narrative of this presentation on RNA mediated molecular epigenetics and virus driven entropy, I mentioned that Cori Bargmann is scheduled to deliver a lecture entitled “Genes, neurons, circuits and behavior: an integrated approach in a compact brain.” An integrated approach will help others understand what is currently known about how ecological variation leads to ecological adaptation. Works, like hers, with the nematode model organism will help others understand how ecological adaptation leads to biodiversity in the morphological phenotypes…

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Ignore the evidence: Rachel Feltman

“There is incontrovertible evidence that Alzheimer’s Disease has a dormant microbial component. We can’t keep ignoring all of the evidence” –Professor Douglas Kell, Manchester University Experts Say There’s a Herpes-Alzheimer’s Link Excerpt: …herpes has been linked to damage in the central nervous system and the limbic system, which is associated with mental decline and personality changes, the Telegraph reported. The experts called for a deeper investigation into the connection. Calm down: Herpes probably isn’t going to give you Alzheimer’s Excerpt:…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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