RNA-directed DNA methylation

Orchestrated death: J. Michael Bailey

A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development 10/7/21 Epigenetic manipulation of the human VNTR was sufficient to switch off ZNF558 expression and thereby increase SPATA18 expression. Our data reveal the co-option of a TE-controlling KZFP to regulate a protein-coding gene and how this regulatory network is controlled between species and human individuals by a cis-acting structural variation. Presumably, the molecular mechanisms are the same in people with gender dysphoria. Reported…

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Orchestrated death: Philip C. Ball

Topological phonon-polariton funneling in midinfrared metasurfaces 10/8/21 was reported as Researchers announce photon-phonon breakthrough Re: “…coupling of topological light and lattice vibrations to form chiral half-light half-vibration excitations…” Light-activated changes in the pH-dependent functional structure of vibrating supercoiled DNA links God’s Creation of sunlight and humidity to biophysical constraints on the chemistry of achiral glyine in position 6 in the gonadotropin hormone releasing hormone (GnRH) decapeptide (in all jawed vertebrates). See: Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor…

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Orchestrated death: Sir Paul Nurse

Epigenetics, the misunderstood science that could shed new light on ageing 10/10/21 …some people include RNA modifications in their definition of epigenetics… That’s why Ewan Birney… says that epigenetic sequencing stands poised to revolutionise science: “We’re opening up an entirely new world.” That’s why the biologically uninformed science idiot, Ewan Birney blocked me from seeing his tweets. He knows that our 1996 Hormones and Behavior review included a section on molecular epigenetics. See: From Fertilization to Adult Sexual Behavior. We…

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Orchestrated death: Francis S. Collins

MicroRNA-155 and antiviral immune responses 10/8/21 The microRNA, miR-155 regulates both adaptive and innate immune responses. …dysregulated expression of miR-155 can result in virus persistence and disruption of the normal response to viral infections. This collaboration among researchers from Iran, UCLA, and South Africa attests to facts that led Francis S. Collins to resign as NIH director. See first: Collins was the first to plan his escape from prosecution. Watch this blog site as others get thrown under the bus…

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God’s microRNA-mediated Creation of genotypes (9)

Watch for the 2021 Nobel Prize in Chemistry (10/6/21) to be linked from claims about the diet of moths and their physiology of reproduction to today’s resignation of NIH Director, Francis S. Collins, or to corruption among members of the Nobel Prize Committee. With few exceptions, awards in the “hard sciences” (Physics, Chemistry, Physiology and Medicine) link the light-activated proton motive force from the ATP-dependent Creation of microRNAs, RNA, and RNA interference to the pH-dependent physiology of reproduction across kingdoms…

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God’s microRNA-mediated Creation of genotypes (8)

See first: God’s microRNA-mediated Creation of genotypes (7) The current issue of Science Magazine supports Trump’s claim via the claims in: Protein-coding repeat polymorphisms strongly shape diverse human phenotypes 9/23/21 The repeat polymorphisms vary with ethnicity, which explains the link from what different human populations eat to the pheromone-regulated genetic processes of reproduction across kingdoms from cyanobacteria to humans. See next: An integrated network analysis approach to identify potential key genes, transcription factors, and microRNAs regulating human hematopoietic stem cell…

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God’s microRNA-mediated Creation of genotypes (7)

Molecular Biology Empowering a community publishing articles in Molecular Biology, including RNA biology, chromatin and epigenetics, gene expression, translation, DNA replication and repair, nuclear organization, gene editing, and much more. Advanced Search 13,006 results for microRNA Most recent: Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis 9/30/21 See also: 43,893 results for viruses and Micrornas 73,770 results for Potential Therapeutic Effect of Micrornas See for comparison: More than 128,300 indexed publications on PubMed…

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God’s microRNA-mediated Creation of genotypes (6)

microRNA 128,290 results. I was too busy to post links to articles when the total number of indexed publications hit 128,000. But see: Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis 9/30/21 These results indicate possible therapeutic use of stable anti-miR-24, albeit administered by other routes, in diseases that are alleviated by STING. miR-24 is known to affect brain development and fetal neuronal differentiation [69]; however these effects should have little bearing on…

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God’s microRNA-mediated Creation of genotypes (5)

Summary: Energy-dependent changes in single nucleotide polymorphisms (SNPs) in microribonucleic acids (microRNAs/miRNAs) were linked from femotosecond blasts of UV light to DNA repair via an extremely sensitive assay for the label-free optical detection and suppression of interfering effects caused by non-specific binding. Interactions in Augmented and Mixed Reality: An Overview 9/20/21 (This article belongs to the Special Issue Extended Reality: From Theory to Applications) All interactions are energy-dependent and microRNA-mediated. ~250 newly indexed articles attest to that fact, which is…

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God’s microRNA-mediated Creation of genotypes (2)

More than 127,000 indexed published works link God’s energy-dependent Creation of microRNAs to all biodiversity via energy-dependent microRNA-mediated DNA supercoiling . See: microRNA See first: God’s microRNA-mediated Creation of genotypes (1) See also: MiR-125b regulates the differentiation of hair follicles in Fine-wool Sheep and Cashmere goats by targeting MXD4 and FGFR2 9/6/21 If you can’t link this to chromosomal rearrangements and sympatric speciation in species from flies to labradoodles, you haven’t played the STEM toy for ages 14+ “Genotype.” One…

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