Orchestrated death: J. Michael Bailey
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development 10/7/21 Epigenetic manipulation of the human VNTR was sufficient to switch off ZNF558 expression and thereby increase SPATA18 expression. Our data reveal the co-option of a TE-controlling KZFP to regulate a protein-coding gene and how this regulatory network is controlled between species and human individuals by a cis-acting structural variation. Presumably, the molecular mechanisms are the same in people with gender dysphoria. Reported…