RNA-directed DNA methylation

Psychophysical Laws of Biology: RNA-mediated nutritional psychiatry (3)

March 27, 2018
James Kohl
Adaptations, Alternative Splicings, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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Psychophysical Laws and the Superorganism  (open access) …superorganisms may also exhibit such behaviour, suggesting that these laws arise from fundamental mechanisms of information processing and decision-making. Reported on Jun 14, 2013 as Nutrient-dependent/pheromone-controlled adaptive evolution: a model and again on: Mar 27, 2018 as Honeybees may unlock the secrets of how the human brain works The study… found that superorganisms may obey the same laws as the human brain. Kohl’s “Laws of Biology” and Darwin’s “conditions of life” can now be…

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RNA-mediated nutritional psychiatry (2)

March 27, 2018
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity
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Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease. Neo-Darwinian theorists dispense with Darwin’s food energy-dependent  “conditions of life.” They link mutations and disease to evolution via mathematical models. They exemplify human idiocy. See for example: Neopterygian phylogeny: the merger assay Reported as: Adaptive radiations in the Mesozoic Bony fishes are the most diverse of all…

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Light-controlled cell biology (revisited)

March 21, 2018
James Kohl
Adaptations, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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See Sci-Bay Scholar for citations and downloads of more than 3300 published works that link viruses to microRNAs Summary: …either the organized genomes of all cell types use the energy source, or viruses use the biophysically constrained energy of the cell types. No extant species can be used as an example of how the virus-driven theft of quantized energy can be linked from natural selection to the evolution of a new species. See also, with my emphasis: Light Offers New…

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Autophagy in health and disease (1)

March 21, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors Each of these pathways have an intimate relationship with the programmed death pathways of autophagy and apoptosis and share a common link to the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) and the mechanistic target of rapamycin (mTOR). Circadian clock genes are necessary to modulate autophagy, limit cognitive loss, and prevent neuronal injury. Non-coding RNAs can control neuronal stem cell…

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Polymaths and paradigm shifts: From Asimov to Bear (5)

March 14, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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Summary: Neil deGrasse Tyson and Lawrence Krauss are among those who have continued to substitute pseudoscientific nonsense for legitimate facts, which is what Hawking did in every book he ever wrote, and each time he made a spurious claim based on his abilities as a conniving theorist whose works still have not been confirmed-and-validated. Now that he is gone, others may proclaim the greatness of his intellect and lionize the magnitude of his influence because they also are biologically uninformed…

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Polymaths and paradigm shifts: from Asimov to Bear (3)

March 14, 2018
James Kohl
Adaptations, Alternative Splicings, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity
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Polymaths and paradigm shifts: from Asimov to Bear (2) “Teilhardism And The New Religion: A Thorough Analysis of the Teachings of Pierre Teilhard de Chardin”, p.18, TAN Books The evolutionist thesis has become more stringently unthinkable than ever before. — Dr. Wolfgang Smith (2015). A Chat with Information Scientist Pedro Marijuán (2017) I’ve based my informational scheme of the cell on this thinking of “distinction on the adjacent” — where molecular recognition is the essential phenomenon over which biological complexity…

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Polymaths and paradigm shifts: from Asimov to Bear (2)

March 14, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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Polymaths and paradigm shifts: from Asimov to Bear (1) See also: Search results for virus-driven energy theft Summary: The creation of enzymes, such as ATP synthase is energy-dependent. The energy biophysically constrains viral latency via the creation of microRNAs and RNA-mediated amino acid substitutions that differentiate the cell types of all living genera. Modifying Other’s Originality without Quote is an Act of Piracy A writer who does not cite the sources in h/h feature article is committing piracy. Piracy is…

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An evolutionary theory killer

How to create biologically uninformed theorists

March 13, 2018
James Kohl
Adaptations, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic
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Summary: On March 2, 2018, Philip C. Ball and Nick Lane started making claims about proton gradients. Their claims are based on my model of quantized energy as information. This post includes added support for what is known to all serious scientists about the light-activated endogenous substrates that link molecular epigenetics to RNA-mediated autophagy. See first: Energy as information and constrained endogenous RNA interference (audio/visual aid 2017) Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding…

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Carl Zimmer refutes theistic evolution (1)

March 9, 2018
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
One Comment

Primers: From photons to the proton motive force (1) and From photons to the proton motive force (2) George Church, Feng Zhang, Francis S. Collins, Stuart Kauffman, Emily Witkin, and Bill Gates are joined by Carl Zimmer. All have now refuted theistic evolution via their failed attempts to link photons from mutations to the proton motive force, or their ridiculous claims linked to the magic of evolution. Carl Zimmer may be the only so-called science journalist to have published a…

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From photons to the proton motive force (2)

March 9, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, What's in the News
One Comment

If you know someone who has linked differences in the energy of photons from the proton motive force to the physiology of reproduction and all biophysically constrained biodiversity, ask if they will attend Schrödinger at 75-The Future of Biology For contrast, touting genetic evolution is not the future of biology. See: Abstract: K06.00013 : A Path Integral Method for Analytically Tractable Inference of Evolutionary Dynamics Understanding the forces that shape genetic evolution is a subject of fundamental importance in biology…

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