RNA-directed DNA methylation

Anti-entropic sunlight: Schrödinger’s Creationist Secret? (2)

  Arabidopsis mRNA decay landscape arises from specialized RNA decay substrates, decapping-mediated feedback, and redundancy The decay of mRNA plays a vital role in modulating mRNA abundance, which, in turn, influences cellular and organismal processes. In plants and metazoans, three distinct pathways carry out the decay of most cytoplasmic mRNAs: The mRNA decapping complex, which requires the scaffold protein VARICOSE (VCS), removes a protective 5′ cap, allowing for 5′ to 3′ decay via EXORIBONUCLEASE4 (XRN4, XRN1 in metazoans and yeast),…

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Anti-entropic sunlight: Schrödinger’s Creationist Secret? (1)

Summary: Perhaps Daniel Dennett will make people feel better about the unnecessary suffering and premature death. Daniel Dennett is scheduled to present the Keynote Lecture at Schrödinger at 75 – The Future of Biology – September 2018 For insight into his philosophical perspective see: How to Criticize with Kindness: Philosopher Daniel Dennett on the Four Steps to Arguing Intelligently 1) You should attempt to re-express your target’s position so clearly, vividly, and fairly that your target says, “Thanks, I wish…

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The MicroRNAome Strikes Back: A Sokalian hoax (10)

Linda Buck, Ben Feringa, Michael Gazzaniga, Christof Koch, Nick Lane and Svante Paabo are among the presenters who will almost undoubtedly discuss some or all of my claims. Prepare to ask questions or intelligently discuss accurate representations of top-down causation by watching this: The energy-dependent creation of the microRNAome protects the organized genomes of all living genera from the virus-driven degradation of messenger RNA that links mutations to all pathology. See: The Bull Sperm MicroRNAome and the Effect of Fescue…

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The MicroRNAome Strikes Back: A Sokalian hoax (9)

Summary: Darwin’s “conditions of life” link the creation of sunlight from the creation of ATP to the creation of microRNAs and RNA-mediated cell type differentiation in the context of biophysically constrained viral latency. There is no magical creation of an RNA force field or protein force field that could be used to link the magic of evolution to biologically-based diversity in species from microbes to humans. RNA force field with accuracy comparable to state-of-the-art protein force fields The complex and…

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BiondVax Universal Flu Vaccine Patent

Summary: …the dream to create an effective universal flu vaccine to ultimately eradicate the flu is placed into the context of claims about changes to the virus. The changes are energy-dependent ecological adaptations. No one claims that the virus mutates or that it evolves. Only biologically uninformed theorists make such ridiculous claims. BiondVax Universal Flu Vaccine Patent Granted in India The patent describes influenza vaccines comprised of multiple copies of several epitopes, such as M-001 which contains nine common and…

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http://nnjournal.net/article/viewFile/2354/1850/10234

The MicroRNAome Strikes Back: A Sokalian hoax (5)

Premise: Sunlight is the quantized energy as information that is required to link endogenous RNA interference to healthy longevity (The energy-dependent creation of microRNAs links the physiology of reproduction from changes in electrons to ecosystems in all living genera via the creation of ATP, RNA, and supercoiled DNA in organized genomes.) Counter claim:  The Quantum Thermodynamics Revolution: Information theory Understanding entropy as a subjective measure allows the universe as a whole to evolve without ever losing information. See, for comparison: On…

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The MicroRNAome Strikes Back: A Sokalian hoax (2)

The problem with -omics has repeatedly been detailed in articles from social scientists and other theorists who fail to link what is known to serious scientists about the microRNAome to their theories. Pseudoscientists continue to create bricks that clutter the metaphorical physical landscape and prevent the epigenetic landscape from being linked from the physiology of nutrient energy-dependent pheromone-controlled reproduction to all cell type differentiation via energy-dependent changes in atoms to ecosystems in all living genera. On 1/22/18, I discussed this with…

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The MicroRNAome Strikes Back: A Sokalian hoax (1)

Summary: How can this not be a Sokalian hoax? The creation of sunlight is not linked to anti-entropic virucidal energy-dependent  cell-type-specific epigenetic modifications. The quantized energy-dependent epigenetic modifications include RNA-directed DNA methylation, histone modification, nucleosome remodeling and higher-order chromatin reorganization. Instead, the magic of non-cell autonomous DNA methylation in plants is placed into in the context of the cytosine residue in CG, CHG and CHH sequence contexts (where H represents A, T or C). See for comparison: Analysis of 6,515 exomes reveals…

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http://nnjournal.net/article/viewFile/2354/1850/10234

A mental health problem at the highest level (2)

Biologically uninformed theorists and so-called science journalists have ignored their own mental health issues and focussed their attention on the mental health of serious scientists. Some of the serious scientists advise the President of the United States in attempts to help him make America great again by draining the political and academic swamps. It is time to examine the personality disorders of theorists and biologically uninformed journalists for comparison to the mental health of serious scientists and the President of…

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http://nnjournal.net/article/viewFile/2354/1850/10234

Diet-driven RNA interference and mental health (1)

The historical record of facts about the transgenerational epigenetic inheritance of RNA-mediated diet-driven mental health must be viewed in the context of the claims made by neo-Darwinian theorists and “Big Bang” cosmologists. They refused to link the creation of the anti-entropic virucidal energy of sunlight on contact with water from the creation of microRNAs to all biodiversity on Earth via the creation of enzymes. They still refuse to acknowledge the fact that the physiology of pheromone-controlled reproduction in species from…

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