RNA Directed

microRNA-mediated replication timing (1)

The phylogenetic utility and functional constraint of microRNA flanking sequences links the patent for naturally occurring light-activated carbon fixation to viral latency and healthy longevity across kingdoms. The patent: RNA-Guided Human Genome Engineering was linked from functional constraints to gain-of-function research in High-Quality Overlapping Paired-End Reads for the Detection of A-to-I Editing on Small RNA WHO failed to examine the problems associated with gain-of-function research, which researchers now suggest led to the creation of SARs-CoV-2. The creation of SARs-CoV-2 can be…

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Light-activated carbon fixation did not evolve (5)

See first: The tipping point (revisited): 120K 5/12/21 Church Speaks: The cyanobacteria fix [carbon via] light…Under ideal circumstances, they can be maybe seven to ten times more productive per photon.” George M. Church et al patented this naturally occurring process. On 5/12/21, I was pleasantly surprised to see the facts represented in this trail-side placard at Canyonlands National Park. The facts make this patent worthless: RNA-Guided Human Genome Engineering See why: Light-activated binding together of sand and other soil particles…

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Quantum biology vs atheism (1)

Peptide synthesis at the origin of life links quantum coherence to coherently organized biology via biophysically constrained viral latency. See: Identification of a micropeptide and multiple secondary cell genes that modulate Drosophila male reproductive success 4/13/21 A noncoding RNA generates amino acid peptides and energy-dependent sperm-competition phenotypes. Moving forward across species, see: Circular RNAs: Novel potential regulators in embryogenesis, female infertility, and pregnancy‐related diseases 4/20/21 Circular RNAs (circRNAs) are endogenous noncoding RNAs with unique cyclic structures. Although they were previously considered…

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Quantum Darwinism (9)

Beyond the Elements: Life (video with transcript) There was a turning point, the evolution of a transformative series of chemical reactions that, over time, remade the planet… They place God’s Creation of sunlight and humidity at the origin of life (THE turning point) into the context of experimental evidence of enzyme-dependent directed evolution, which requires this stupid assumption from 2005. “Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.” Enzymes are proteins. No experimental evidence of…

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Quantum Darwinism (8)

An engineered membrane-bound guanylyl cyclase with light-switchable activity 3/29/21 Expressing switch-Cyclop1 in the cells or tissue of interest will allow non-invasive and reversible manipulation of cGMP levels to a degree which is not possible by pharmacological intervention. The patented cure for all virus-driven pathology links naturally occurring light-activated carbon fixation to biophysically constrained viral latency. That means every intelligent person on Earth can help to end neo-Darwinian pseudoscientific nonsense by learning about quantum Darwinism. See for instance: RNA-Guided Human Genome…

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Quantum Darwinism (6)

Learn how sunlight and humidity link photosynthesis from construction of the cell wall  to biophysically constrained viral latency via God’s ATP-dependent Creation of RNA.   For links from the light-activated assembly of the microRNA-RNA-peptide nanocomplex across kingdoms via the Creation of enzymes see: Castration increases and androgens decrease nitric oxide synthase activity in the brain: physiologic implications (2000) and Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination (2017) The nitric oxide…

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Quantum Darwinism (5)

See with my added emphasis: Parallel genetics of regulatory sequences using scalable genome editing in vivo 4/13/21 [Energy-dependent biophysically-constrained microRNA-mediated] Regulatory elements must ultimately be understood within their genomic environment and development- or tissue-specific contexts. Gene-centric theorists are too stupid to start with God’s Creation of energy, which must be linked from regulatory elements to regulation of the genomic environment before the effects of energy can be understood in any context whatsoever. See for context: Energy as information and constrained…

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Quantum Darwinism (4)

How metformin affects various malignancies by means of microRNAs: a brief review 4/13/21 Metformin adjusts cellular energy metabolism through…an important metabolic sensor that is activated under cellular stress conditions and limits energy consumption by affecting ATP production and consumption [1, 2]. The link from naturally occurring light-activated carbon fixation to God’s ATP-dependent Creation of RNA, protonated RNA interference, and biophysically constrained viral latency became clearer in 1964. Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism…

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Quantum Darwinism (3)

“Quantum biology” is quantum Darwinism Starting from…discovery of quantum coherence in low-temperature photosynthetic microbes in 2007, quantum coherence is emerging as a general principle of biological systems. See: MicroRNAs organize intrinsic variation into stem cell states 3/5/20 …naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology. Theorists chose neo-Darwinian pseudoscientific nonsense about beneficial mutations and evolution via natural selection across billions to millions of years instead of the explanatory power of quantum Darwinism. Their ignorance…

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Quantum Darwinism (2)

Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid 2/5/21 Orgel and Szostak introduced an amino group into 2′- and 3′-positions9, which enabled effective RNA copying due to acceleration of the ligation reaction10,11. Reported as: Origins of life could have started with DNA-like XNAs 4/6/21 …shorter L-aTNA fragments came together and linked up with each other on the longer L-aTNA template. Critically, this happened in the presence of a compound, called N-cyanoimidazole, and a metal ion, like manganese, both of…

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