RNA Directed

Social experiences epigenetically effect gene networks

Networks of Genes Respond to Social Experiences October 13, 2013, from Searching for the Mind with Jon Lieff, M.D. Excerpt 1: “The gene networks of social experience are consistent through many animals.” My comment: Not just many animals; the gene networks of social experiences must be consistent in all animals that adaptively evolved. You cannot get from microbes to man with any consistent model of cause and effect until you realize that the molecular mechanisms that enable cause and effect…

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Understanding the role of mutations and evolution

On  Fri Aug 16, 2013 at 10:21 am,  Clarence ‘Sonny’ Williams wrote: “As for mutations, some members of this group might have a misunderstanding regarding the role of mutations and evolution.  A review of college textbooks on evolution reveal this: Mutations are any change to the genomic sequence of an organism and mutations ARE REQUIRED for evolution. Yes, there are a few scientists who argue for such things as “genetic engineering” (e.g., James Shapiro) and “germ line epigenetic inheritance” in mammals (e.g., Eva…

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Alzheimer's, microRNAs, and olfaction

A Blood Test for Alzheimer’s? Circulating microRNAs could help doctors diagnose the neurodegenerative disease. By Jef Akst | July 30, 2013 Excerpt: “Testing the blood of 202 people for 140 different microRNAs (miRNAs), a team of researchers at Saarland University, in Germany, identified 12 RNA fragments circulating at consistently different levels in healthy people and patients with Alzheimer’s…” My comment: In my model, the microRNA/messenger RNA balance is nutrient-dependent and pheromone-controlled. The epigenetic landscape becomes the physical landscape of DNA…

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Pheromones and cancer

Transcription Factor-MicroRNA-Target Gene Networks Associated with Ovarian Cancer Survival and Recurrence Excerpt: “MicroRNAs (miRNAs) are small, non-coding RNA molecules that bind to complementary sequences on target mRNA transcripts, and thus, regulate gene expression at the post-transcription stage. Transcription factors (TFs) are a different type of regulator. These proteins bind to specific DNA sequences in the promoter region, promoting or repressing transcription into mRNA, and thus, regulate genes at a pre-transcription stage [4]. TFs and miRNAs can regulate each other and…

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