RNA Directed

Understanding the role of mutations and evolution

On  Fri Aug 16, 2013 at 10:21 am,  Clarence ‘Sonny’ Williams wrote: “As for mutations, some members of this group might have a misunderstanding regarding the role of mutations and evolution.  A review of college textbooks on evolution reveal this: Mutations are any change to the genomic sequence of an organism and mutations ARE REQUIRED for evolution. Yes, there are a few scientists who argue for such things as “genetic engineering” (e.g., James Shapiro) and “germ line epigenetic inheritance” in mammals (e.g., Eva…

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Alzheimer's, microRNAs, and olfaction

A Blood Test for Alzheimer’s? Circulating microRNAs could help doctors diagnose the neurodegenerative disease. By Jef Akst | July 30, 2013 Excerpt: “Testing the blood of 202 people for 140 different microRNAs (miRNAs), a team of researchers at Saarland University, in Germany, identified 12 RNA fragments circulating at consistently different levels in healthy people and patients with Alzheimer’s…” My comment: In my model, the microRNA/messenger RNA balance is nutrient-dependent and pheromone-controlled. The epigenetic landscape becomes the physical landscape of DNA…

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Pheromones and cancer

Transcription Factor-MicroRNA-Target Gene Networks Associated with Ovarian Cancer Survival and Recurrence Excerpt: “MicroRNAs (miRNAs) are small, non-coding RNA molecules that bind to complementary sequences on target mRNA transcripts, and thus, regulate gene expression at the post-transcription stage. Transcription factors (TFs) are a different type of regulator. These proteins bind to specific DNA sequences in the promoter region, promoting or repressing transcription into mRNA, and thus, regulate genes at a pre-transcription stage [4]. TFs and miRNAs can regulate each other and…

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