RNA Directed

From optoribogenetics to HelioRiboGenetics (2)

See first: From optoribogenetics to HelioRiboGenetics (1) For consistency see Abcam’s: Spotlight on Neuroscience [and the 2020 Nobel Prize for Physiology or Medicine] Abcam’s forthcoming live sessions Adult Neurogenesis  Building and Reparing the Brain Epigenetics in the Nervous System On-demand webinars Role of chronic inflammation in risk for neurodegenerative disorders: Alzheimer’s disease Autophagy and Neurodegeneration Chronic virus-driven inflammation perturbs epigenetic effects on energy-dependent microRNA-mediated autophagy, which prevents neurodegeneration. Attempts to discredit Judy A. MIkovits for her role in linking God’s…

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From optoribogenetics to HelioRiboGenetics (1)

Optoribogenetic control of regulatory RNA molecules 9/24/20 “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Had he lived, Bruce S. McEwen probably would have received the 2020 Nobel Prize in Physiology or Medicine for linking God’s Creation of UV light and water from energy-as-information to biophysically constrained viral latency across kingdoms. McEwen et al., (1964) linked that heliocentric approach to scientific creationism…

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Optoribogenetic-driven sympatric speciation (2)

See the 7-part series: Predicting who wins the 2017 Nobel Prizes (7) Conclusion: The biggest threat to humanity is not the “Big Bang” theory of creation or the “Big Bang” theory of how life on Earth might end after an explosion of cosmic proportions. The biggest threat has always been “human idiocy.” For examples of human idiocy, see anything published by any researcher or any research group that failed to link God’s Creation of UV light and water from oxidative…

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Optoribogenetic-driven sympatric speciation (1)

For presentation during session: Polycomb and chromatin remodeling Historical perspective: Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes… Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at…

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UV light, H2O, and epigenetic effects… (3)

Trump nominates conservative Amy Coney Barrett for Supreme Court She would be the only justice on the current court not to have received her law degree from an Ivy League school. The eight current justices all attended either Harvard or Yale. Most researchers at Harvard and Yale failed to admit, and failed to teach their students, that God’s Creation of UV light and water biophysically constrains viral latency across kingdoms via oxidative phosphorylation. They are being forced to tell the…

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UV light, H2O, and epigenetic effects… (1)

See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective,…

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Coherently organized healthy longevity (4)

See first: Coherently organized healthy longevity (3) “Perfect Pairing” prevents cancer and all other forms of virus-driven pathology. Biologically uninformed science idiots have placed everything known to serious scientists about biophysically constrained “perfect pairing,”microRNA-mediated viral latency, and healthy longevity into the context of computational biology and chemistry via theoretical pairing. See their ridiculous claim in Computational prediction of miRNA/mRNA duplexomes at the whole human genome scale reveals functional subnetworks of interacting genes with embedded miRNA annealing motifs …a very large…

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Coherently organized healthy longevity (3)

  Development of MicroRNAs as Potential Therapeutics against Cancer 7/15/20 The perfect pairing of the miRNA with the target mRNA promotes mRNA degradation, while imperfect base pairing will lead to protein translational repression. God’s UV light-activated “Perfect Pairing” prevents cancer and all other forms of virus-driven pathology. See: Light-mediated strong coupling between a mechanical oscillator and atomic spins 1 meter apart 5/10/20 To achieve quantum-coherent coupling (40), g must also exceed all thermal and quantum back-action decoherence rates. This is…

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Coherently organized healthy longevity (1)

A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

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pH-dependent healthy longevity (1)

Who else linked pH-dependent viral latency to pH-dependent healthy longevity via the Korean Genome Project‘s ethnicity-specific reference genome sequences? The facts about energy-dependent microRNA-mediated biophysically constrained viral latency can be compared to ridiculous theories from the gene-centric Human Genome Project touted by NIH Director, Francis S. Collins. Other neo-Darwinian theorists also failed to start with facts about God’s Creation of UV light and water, which Charles Darwin included in his energy-dependent “conditions of life” Darwin’s “conditions of life” presciently linked…

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