RNA interference

Information Wars started by medical practitioners (1)

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (Apr 11, 2018) My Summary: The pheromone-controlled physiology of reproduction biophysically constrains viral latency and the transgenerational epigenetic inheritance of healthy longevity in the context of fixation of the EDAR V370A variant. The variant links changes in a single base pair to differences in an amino acid substitution, which links the mouse-to-human model of ecological adaption from microbes to all extant morphological and behavioral biodiversity. See for comparison: Biological Networks: An Introductory…

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Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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An evolutionary theory killer

Cardiac energy metabolism requires units of energy

Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism (First published May 17, 2018 ) Silencing the mRNA of general control of amino acid synthesis 5-like protein 1 reduced acetylation of LCAD and βHAD as well as fatty acid oxidation rates in cardiomyocytes. Thus, hypertrophy in CHDs prevents the postnatal increase in myocardial acetylation, resulting in a delayed maturation of cardiac fatty acid oxidation. The virus-driven theft of quantized energy causes the silencing of mRNA, which generally controls amino…

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Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

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An evolutionary theory killer

The concept of a species (3)

Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction (2005) This remodeling of LH circuitry could contribute to the chronic deficit in reward function that has been hypothesized to drive the transition to drug addiction. Lena D. van der Stap discussed her role in the publication of this article, which failed to make any assumptions about mutations and/or evolution. James Kohl Did you co-author Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction McEwen told…

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MicroRNA-mediated alternative splicing (revisited)

Building one molecule from a reservoir of two atoms reported as: Cold chemistry with two atoms. They linked differences in the energy of photons from two different wavelengths of light, 700 nm and 976 nm, to the creation of the molecule NaCs*. They were able to detect molecule formation in the context of atom loss and NaCs* vibrational levels near the dissociation threshold. Detecting resonances that have not been previously observed appears to be the link from quantum physics to…

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Corporate owned microRNA-mediated biodiversity

Corporate control and global governance of marine genetic resources Who owns ocean biodiversity? All biodiversity is quantized energy-dependent and RNA-mediated in the context of the physiology of reproduction and pheromone-controlled RNA interference (RNAi) . Naturally occurring light-activated RNAi ensures viral latency, which helps to ensure healthy longevity. George Church et al, own this patent on RNA interference, which suggests that he and others own all biodiversity in the context of the Virus-mediated archaeal hecatomb in the deep seafloor and patent…

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Misleading evidence, Raman Hyperspectroscopy and FB jail

Yesterday, on the topic of vaccines used to prevent Ebola virus transmission, I wrote: …. There is no such thing as an extinct virus. Their ability to steal energy is biophysically constrained until nutrient stress and/or social stress cause their reactivation. I provided a link to The Darwin Code Today, I read about The misleading evidence that fooled scientists for decades After posting this comment to “The Conversation,” I learned I was blocked from posting anything to Facebook. Have you considered…

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The eternal significance of microRNAs and the Vietnam Memorial (2)

Summary: Quantized energy as information has been linked from what organisms eat to biophysically constrained membrane protein construction in the context of viral latency and healthy longevity. Cryoelectron microscopy (aka electron cryomicroscopy for obfuscation) clearly links what is known about the virus-driven degradation of messenger RNA to all pathology or from energy-dependent RNA-mediated DNA repair to species survival. Membrane Proteins – Richard Henderson May 31, 2018 Energy as information and biophysically constrained membrane protein construction – James Kohl Feb 15,…

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