RNA interference

RNA-mediated radiosensitivity (1)

I posted this to microRNA.pro after resolve of an access issue. It now appears as part two of The Tipping Point (revisited): 90K (2) I will follow up on the link to RNA-mediated radiosensitivity after consideration of Maximum Entropy (Most Likely) Double Helical and Double Logarithmic Spiral Trajectories in Space-Time, which was reported in today’s news as Kepler’s Forgotten Ideas about Symmetry Could Explain Spiral Galaxies Without the Need for Dark Matter 8/8/19 Watch as everything known about biophysically constrained…

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Food energy-as-information, and consciousness

Informational Mode of the Brain Operation and Consciousness as an Informational Related System (6/7/19) Conclusion: consciousness could be fully described and understood in informational terms. In the same issue, the food that organisms eat is linked to human consciousness via natural selection for energy-dependent codon optimality. Codon optimality biophysically constrains viral latency via the physiology of pheromone-controlled reproduction and fixation of RNA-mediated amino acid substitutions. The amino acid substitutions link food energy as information to transgenerational epigenetic inheritance of healthy…

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Trump-hating advocates of vaccines + GMOs (2)

Trump-hating advocates of vaccines + GMOs (1) Conclusion: People who understand the facts about how energy-dependent ecological adaptations to viruses across kingdoms and across generations prevent pathology do not need more theoretical models. For instance, see: Genome-Wide Study Reveals a Novel Regulatory Pathway: Translation Affects mRNA Stability in a Codon-Dependent Manner on June 26, 2019. It is time to force theorists to move forward. Trump-hating advocates of vaccines + GMOs (2) For an attempt to return to the neo-Darwinian pseudoscientific…

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Virus-driven downsizing of the human brain (5)

Virus-driven downsizing of the human brain (3) (8/9/16) Virus-driven downsizing of the human brain (4) (4/23/17) Who the heck is James V. Kohl? Thanks for asking. Posted by u/Sphinx_for_hire 3 months ago I’m in biochemistry/toxicology and was reading up on LUCA (aka Last Universal Common Ancestor). While Googling the work of Nick Lane, I stumbled upon the following page absolutely flaying Lane’s and others’ LUCA theories. This guy, James V. Kohl, has many websites in which he writes about human…

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Preprints obfuscate facts (1)

How many preprints should be published? If someone posts something crazy like vaccines cause autism, I don’t think respectable news outlets will cover it without first discussing the preprint with experts. The light-activated assembly of the microRNA-RNA-peptide nanocomplex and the cure for all cancer was reported by researchers from Israel and discussion by so-called experts followed: See: A cure for cancer? Israeli scientists say they think they found one 1/28/19 The company is now writing patents on specific peptides, which…

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Information Wars started by medical practitioners (1)

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (Apr 11, 2018) My Summary: The pheromone-controlled physiology of reproduction biophysically constrains viral latency and the transgenerational epigenetic inheritance of healthy longevity in the context of fixation of the EDAR V370A variant. The variant links changes in a single base pair to differences in an amino acid substitution, which links the mouse-to-human model of ecological adaption from microbes to all extant morphological and behavioral biodiversity. See for comparison: Biological Networks: An Introductory…

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Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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An evolutionary theory killer

Cardiac energy metabolism requires units of energy

Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism (First published May 17, 2018 ) Silencing the mRNA of general control of amino acid synthesis 5-like protein 1 reduced acetylation of LCAD and βHAD as well as fatty acid oxidation rates in cardiomyocytes. Thus, hypertrophy in CHDs prevents the postnatal increase in myocardial acetylation, resulting in a delayed maturation of cardiac fatty acid oxidation. The virus-driven theft of quantized energy causes the silencing of mRNA, which generally controls amino…

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Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

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An evolutionary theory killer

The concept of a species (3)

Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction (2005) This remodeling of LH circuitry could contribute to the chronic deficit in reward function that has been hypothesized to drive the transition to drug addiction. Lena D. van der Stap discussed her role in the publication of this article, which failed to make any assumptions about mutations and/or evolution. James Kohl Did you co-author Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction McEwen told…

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