RNA interference

Virus-driven dietary pathology (1)

Viral Trigger for Celiac Disease? A common, seemingly benign human virus can trigger an immune response that leads to celiac disease in a mouse model, researchers show. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease Editor’s summary: Viruses compound dietary pathology Reoviruses commonly infect humans and mice asymptomatically. Bouziat et al. found that immune responses to two gut-infecting reoviruses take different paths in mice (see the Perspective by Verdu and Caminero). Both reoviruses invoked protective immune…

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Functionally interdependent editing and methylation

Editing and methylation at a single site by functionally interdependent activities …cytosine 32 in the anticodon loop of Trypanosoma brucei tRNAThr is methylated to 3-methylcytosine (m3C) as a pre-requisite for C-to-U deamination. Formation of m3C in vitro requires the presence of both the T. brucei m3C methyltransferase TRM140 and the deaminase ADAT2/3. Once formed, m3C is deaminated to 3-methyluridine (m3U) by the same set of enzymes. ADAT2/3 is a highly mutagenic enzyme4, but we also show that when co-expressed with…

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Cytosis: Biology Content

  Help Me Write Some Biology Content Project Update #5: Cytosis: A Cell Biology Board Game by John Coveyou (Genius Games) Many of you have mentioned that you’d like to have an explanation of the biology behind Cytosis available… and I think that is an AWESOME plan. Every time I’ve taught the game to non-science players in the past, they say gameplay made even more sense (and was so much more enjoyable) when I explained the science as well. This…

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Light-activated feedback loops vs self-organization of ecosystems

John Lieff has been trying to update his ridiculous misrepresentations of biologically-based cause and effect to match the accurate representations we made in a section on molecular epigenetics in our 1996 Hormones and Behavior review. From Fertilization to Adult Sexual Behavior Nothing can stop him, but this will provide the next source for material that he must borrow as if he learned about it somewhere else. Apoptosis analysis guide | Free ebook download Virus-driven energy theft causes apoptosis, which releases…

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Cytosis: A Cell Biology Board Game

Cytosis: A Cell Biology Board Game A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses! 3/27/17 My comment: On March 24, 2017 this article was published in ‘Science.’ A conserved NAD+ binding pocket that regulates protein-protein interactions during aging The article linked virus-driven energy theft from hydrogen-atom transfer in DNA base pairs in solution to all pathology. On March 24, 2017 this article also was published in…

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Who will kill the billion dollar baby? Bill Gates or Donald Trump

Bill Gates is set to meet with the President on Monday. [March 20, 2017] Both men know that virus-driven energy theft is the biggest threat humanity has ever faced. The threat arose in the context of wasted US government funding and wasted funding from philanthropists who supported the CRISPR gene-editing technology. For comparison, The Penrose Institute appears to be prepared to establish itself as a refuge for serious scientists who have been cast out of academia for their failure to…

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Thinking about energy is not radical re-thinking

The brain: a radical rethink is needed to understand it …Optogenetics, a technique that uses genetic modification of neurons so that their electrical activity can be controlled with light pulses – can help us to explore their specific contribution to brain function. Optogenetics links the speed of light on contact with water to what is known about all energy-dependent cell type differentiation in all individuals of all living genera. Serious scientists, for example, have linked angstroms to ecosystems in all living…

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Food for thought: Penrose v Ellis (1)

Food for thought.   The most popular ideas of atheists may still include hypothetical biogenic features that arrived from outer space. That’s how pseudoscientific nonsense appears to become a fact of life on Earth.   All experimental evidence of energy-dependent biologically-based cause and effect must be suppressed or ignored, and that’s what atheists prefer to do. See for instance: Hypothetical biogenic features in the context of the Alan Hills fossil. (Thanks to John Hewitt for reminding me of this.) On…

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Energy-dependent pheromone-controlled entropy (4)

Solar-driven reforming of lignocellulose to H2 with a CdS/CdOx photocatalyst Reported as: Scientists harness solar power to produce clean hydrogen from biomass They claim that the rigid structure of nature’s equivalent to armored concrete evolved to protect plants and trees from degradation. They don’t make claims about what might cause the degradation. They start with the likelihood that degradation automagically occurs. That led them to design a combination of catalyst and solution that mimics how the anti-entropic energy of sunlight…

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Proof: Sunlight is energy as information

Hypothesis: Kallmann’s syndrome is proof that virus-driven energy theft causes all pathology in species from archaea to humans via the degradation of messenger RNA and the loss of one allele.   Thought experiment: Step 1) The loss of one allele and the transgenerational epigenetic inheritance of Zika virus-damaged DNA can be compared to the degradation of messenger RNA in bacteria that is manifested in archaea and L-forms. Step 2) The degradation of messenger RNA in primates differentiates healthy longevity from…

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