RNA interference

Ecological adaptation: A new definition of heredity (3)

Excerpt: Moving forward: Novel and Haplotype Specific MicroRNAs Encoded by the Major Histocompatibility Complex …these data suggest that a subset of the identified novel miRNAs may contribute to the pathophysiology of numerous diseases, laying the groundwork for future studies to elucidate the functional connections of miRNAs to the numerous diseases associated with sequence variants within non-coding regions of the MHC. OMCD: OncoMir Cancer Database Dysregulation of miRNAs is commonly observed in cancers and it largely cancer dependent. The virus-driven theft…

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Ecological adaptation: A new definition of heredity (1)

Excerpt: ” …long-standing presumptions led to the claims made by biologically uninformed theorists who failed to link biophysically constrained viral latency to the recent origin of most protein-coding variants via the physiology of pheromone-controlled reproduction in species from microbes to humans…” She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity May 29, 2018 | 672 Pages From the description of the book: 1) We need a new definition of what heredity is… 2) …Zimmer ultimately unpacks urgent…

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MicroRNAs biophysically constrain behavior (2)

Excerpt: Researchers, like Shunsuke Suzuki, who cannot link photonic coupling from quantum physics to biophysically constrained atomic energy via classical physics and quantum chemistry prevent scientific progress, They are limited to asking questions that have already been answered by serious scientists. MicroRNA 1-20 of more than 70,400 The fact that the energy-dependent creation of microRNAs links RNA-mediated cell type-differentiation to biophysically constrained viral latency and all morphological phenotypes has been established. See: PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers…

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Anti-entropic sunlight: Schrödinger’s Creationist Secret? (5)

Anti-entropic sunlight: Schrödinger’s Creationist Secret? (3) The list of those scheduled to present has changed. Michael Rosbash has been added. John E. Walker is not scheduled, which suggests that everyone else already knows that the creation of the sun’s anti-entropic virucidal energy is the link from the creation of ATP to the creation of RNA and all biophysically constrained viral latency via feedback loops and the physiology of reproduction. Rosbash, as all serious scientists know,  started with energy-dependent changes in…

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Light-activated carbon fixation did not evolve (4)

Summary: Dobzhansky was joking about the time it would take for the creation of light to cause the energy-dependent fixation of RNA-mediated amino acid substitutions, which link food energy to the creation of enyzmes that metabolized food. His joke extends from the creation of sunlight — as the “light of evolution” — to the species-specific pheromone-controlled physiology of reproduction and cell type differentiation in chimpanzees and humans compared to gorillas via one amino acid substitution. The joke was played on…

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The tipping point (revisited): 70,000 publications

Excerpt: This new empirically based perspective on the evolution of genetic novelty will have more explanatory power in the future than the „error-replication“ narrative of the last century. Simply put, all serious scientists have always known that the “error-replication” narrative of the 20th century was a ridiculous misrepresentation of what Darwin placed into the context of his “conditions of life.” The tipping point?: 50,000publications (May 16, 2016) See also: The tipping point (revisited): 69,000 publications (January 20, 2018) Nearly 1000…

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George Church refutes theistic evolution (4)

See: George Church refutes theistic evolution (February 9, 2017) See also: Energy as information and constrained endogenous RNA interference (February 15, 2017) Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid…

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An evolutionary theory killer

Conceptual critique: Innateness vs the death gene (2)

Excerpt: Martie Haselton notes “…there’s a hidden adaptive intelligence that has been shaped over eons. Martie Haselton places that ecological adaptation into the context of the claim that “…our bodies are designed to fight off invaders, whether they take the form of a cold virus… (p 73.) and she mentions the link from the designer to one theory about menstruation: “female bleeding serves to flush out “bad” sperm that may carry bacteria, viruses and other pathogens.” (p. 84) See also:…

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Conceptual critique: Innateness vs the death gene (1)

Summary: The term innate is used in psychological explanations. The so-called explanations ignore facts about the light energy-dependent activation of endogenous substrates. The anti-entropic virucidal energy of sunlight links the endogenous substrates to biophysically constrained viral latency and healthy longevity via the physiology of reproduction in all living genera. “Proximate mechanisms” and “evolution” are terms used by biologically uninformed theorists. That fact becomes perfectly clear in the context of  The conceptual critique of innateness (paywalled) One proposal is that innateness can…

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How to biophysically constrain the flu virus (1)

Excerpt: John E Walker (Factor-dependent archaeal transcription termination) will probably explain the molecular mechanism of how ATP is made, which may be important to know for those who have learned how important ATP is by playing “Cytosis.” The creation of ATP can be linked to the creation of RNA and the prevention of messenger RNA degradation in the context of the Virus-mediated archaeal hecatomb in the deep seafloor. What the flu does to your body, and why it makes you…

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