RNA–Mediated Epigenetic Heredity

From optoribogenetics to HelioRiboGenetics (6)

“How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” 8/8/91 2020 Physics Nobel Laureate, Roger Penrose linked the answer to his rhetorical question from physics to chemistry and molecular biology via the refutation of neo-Darwinian pseudoscientific nonsense and Big Bang cosmology. Quantum coherence has since been linked to coherently organized biology. See: MicroRNAs organize intrinsic variation into stem cell states…

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From optoribogenetics to HelioRiboGenetics (2)

See first: From optoribogenetics to HelioRiboGenetics (1) For consistency see Abcam’s: Spotlight on Neuroscience [and the 2020 Nobel Prize for Physiology or Medicine] Abcam’s forthcoming live sessions Adult Neurogenesis  Building and Reparing the Brain Epigenetics in the Nervous System On-demand webinars Role of chronic inflammation in risk for neurodegenerative disorders: Alzheimer’s disease Autophagy and Neurodegeneration Chronic virus-driven inflammation perturbs epigenetic effects on energy-dependent microRNA-mediated autophagy, which prevents neurodegeneration. Attempts to discredit Judy A. MIkovits for her role in linking God’s…

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Optoribogenetic-driven sympatric speciation (1)

For presentation during session: Polycomb and chromatin remodeling Historical perspective: Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes… Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at…

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UV light, H2O, and epigenetic effects… (3)

Trump nominates conservative Amy Coney Barrett for Supreme Court She would be the only justice on the current court not to have received her law degree from an Ivy League school. The eight current justices all attended either Harvard or Yale. Most researchers at Harvard and Yale failed to admit, and failed to teach their students, that God’s Creation of UV light and water biophysically constrains viral latency across kingdoms via oxidative phosphorylation. They are being forced to tell the…

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UV light, H2O, and epigenetic effects… (1)

See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective,…

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Coherently organized healthy longevity (2)

RNA-mediated.com Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift. Within 8 hours from the time I posted Coherently organized healthy longevity (1) to my blog site at RNA-mediated.com, Quanta Magazine regurgitated this claim from 1/3/19 Quantum error-correcting codes are essential for protecting information in quantum computers. They may also be responsible for…

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pH-dependent healthy longevity (1)

Who else linked pH-dependent viral latency to pH-dependent healthy longevity via the Korean Genome Project‘s ethnicity-specific reference genome sequences? The facts about energy-dependent microRNA-mediated biophysically constrained viral latency can be compared to ridiculous theories from the gene-centric Human Genome Project touted by NIH Director, Francis S. Collins. Other neo-Darwinian theorists also failed to start with facts about God’s Creation of UV light and water, which Charles Darwin included in his energy-dependent “conditions of life” Darwin’s “conditions of life” presciently linked…

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Trump-hating advocates of vaccines + GMOs (2)

Trump-hating advocates of vaccines + GMOs (1) Conclusion: People who understand the facts about how energy-dependent ecological adaptations to viruses across kingdoms and across generations prevent pathology do not need more theoretical models. For instance, see: Genome-Wide Study Reveals a Novel Regulatory Pathway: Translation Affects mRNA Stability in a Codon-Dependent Manner on June 26, 2019. It is time to force theorists to move forward. Trump-hating advocates of vaccines + GMOs (2) For an attempt to return to the neo-Darwinian pseudoscientific…

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Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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NHEJ disruption and HDR correction?

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop is being held in Park Inn by Radisson Pulkovskaya Hotel & Conference Centre St Petersburg, Saint-Petersburg, Russia, September 2-7 2018. We will discuss all aspects…

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