RNA-mediated gene silencing

Public Heath Fascism vs Creationism (4)

2018 Chemistry Nobel Laureate, Frances H. Arnold failed to link the light-activated assembly of the microRNA-RNA-peptide nanocomplex from microRNA biogenesis to her claims about the evolution of enzymes, which were retracted. See: Nobel Prize-winning scientist Frances Arnold retracts paper 1/3/20 “For my first work-related tweet of 2020, I am totally bummed to announce that we have retracted last year’s paper on enzymatic synthesis of beta-lactams. The work has not been reproducible,” she tweeted. beta-lactamase confers penicillin resistance to various bacterial…

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Public Heath Fascism vs Creationism (3)

KB Whaley’s group published Modern Approaches to Exact Diagonalization and Selected Configuration Interaction with the Adaptive Sampling CI Method on 3/11/20 A mathematical model of a simulation of 34 electrons in 152 orbitals was linked from quantum coherence to coherently organized biology via everything known to intelligent serious scientists about inorganic chemistry, organic chemistry, physics, and molecular epigenetics. For a historical perspective see: Molecular Mechanics Simulations and Improved Tight-Binding Hamiltonians for Artificial Light Harvesting Systems: Predicting Geometric Distributions, Disorder, and…

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Creationism, Communism and Corruption (2)

Study investigates effects of COVID-19 vaccine on male fertility 12/20/20 We’re evaluating the sperm parameters and quality before the vaccine and after the vaccine. See Peptide synthesis at the origin of life 11/13/20 for a more thorough evaluation of naturally occurring biophysically constrained viral latency. It refutes this stupid claim from A lunar pandemic [that never was] 12/22/20 The microscopic universe, it turned out, was simply impossible to control. See also: Genome recoding by tRNA modifications 12/1/16 The succession of mRNA…

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Protonated RNA interference vs stupid theories (5)

See first: Protonated RNA interference vs stupid theories (4) See with my emphasis The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19 10/11/20 Noncoding RNAs (ncRNAs) are a class of RNAs not involved in protein production and can be subdivided into small (miRNAs, tRNAs, PIWI‐targeting RNAs) and long ncRNAs (lncRNAs), based upon their size.8 This class of RNAs not only regulates fundamental biological processes including immune system development and regulation, but also plays a…

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Protonated RNA interference vs stupid theories (2)

Protonated RNA interference vs stupid theories (1) Evidence for Hidden Involvement of N3-Protonated Guanine in RNA Structure and Function 1/31/19 Charged nucleobases have been found to occur in several known RNA molecules and are considered essential for their structure and function. Estimating Strengths of Individual Hydrogen Bonds in RNA Base Pairs: Toward a Consensus between Different Computational Approaches 4/30/19 Noncoding RNA molecules are composed of a large variety of noncanonical base pairs that shape up their functionally competent folded structures.…

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Optoribogenetic-driven sympatric speciation (1)

For presentation during session: Polycomb and chromatin remodeling Historical perspective: Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes… Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at…

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UV light, H2O, and epigenetic effects… (1)

See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective,…

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pH-dependent healthy longevity (1)

Who else linked pH-dependent viral latency to pH-dependent healthy longevity via the Korean Genome Project‘s ethnicity-specific reference genome sequences? The facts about energy-dependent microRNA-mediated biophysically constrained viral latency can be compared to ridiculous theories from the gene-centric Human Genome Project touted by NIH Director, Francis S. Collins. Other neo-Darwinian theorists also failed to start with facts about God’s Creation of UV light and water, which Charles Darwin included in his energy-dependent “conditions of life” Darwin’s “conditions of life” presciently linked…

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pH-dependent viral latency (2)

New vaccines protect against COVID-19 in non-human primates, study finds 5/20/20 See for comparison: Vaccines do not control pandemics (1) 5/15/20 I reiterate: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/18/18 Amino acid substitutions at these positions were found to be associated with an inability to serotype a strain and are responsible for antigenic changes48. Recently, amino acid substitutions in the three main antigenic regions, especially at positions 96…

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The tipping point (revisited): 102K (1)

See first:  The tipping point (revisited): 101K (1) 4/22/20 and Vaccines do not control pandemics (1) 5/15/20 Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion 5/11/20 They linked virus-driven changes in light-activated energy-dependent differences in hydrogen-atom transfer in DNA base pairs in solution from microRNA flanking sequences to the degradation of messenger RNA and all obesity-linked diseases via changes in the potential of hydrogen (pH). See: Control of pH responsive peptide self-association…

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