RNA-mediated gene silencing

microRNA-mediated biodiversity (2)

From microRNA-mediated biodiversity (1) See for comparison my blog posts that mention: glycine, which start with Epigenetic regulation of aging by glycine and GnRH 5/26/15 The focus here is on vertebrates, but the conserved molecular mechanisms extend across all species. Who else is watching science journalist John Hewitt continue on his collision course with reality? microRNA-mediated biodiversity (2)

microRNA-mediated biodiversity (1)

I started this series to show biologically uninformed evolutionary theorist that all intelligent serious scientists know how stupid the theorists have always been A clinical and in-silico study of MicroRNA-21 and growth differentiation factor-15 expression in pre-diabetes, type 2 diabetes and diabetic nephropathy 2/1/22 RESULTS: MicroRNA-21 was found to directly target GDF15 downregulating transcription factors microRNA-mediated biodiversity (1)

“The Darwin Code: Intelligent Design without God” (4)

De novo mutation rates at the single-mutation resolution in a human HBB gene-region associated with adaptation and genetic disease, published by Cold Springs Harbor Laboratory Press, was reported as Study uncovers first evidence of long-term directionality in origination of human mutation, challenging neo-Darwinism  1/31/22 Directionality is energy-dependent. If this was the first study of long-term “The Darwin Code: Intelligent Design without God” (4)

RNAi 2002 to AI 2021 (10)

The 6-part series on Energy-dependent epigenetic translation to mRNA stability that ran here between 5/12/17 and 5/22/17 predictably links facts about energy-dependent microRNA-mediated chromosomal inheritance to the end of all the stupid theories that were touted by Gene Levinson in Rethinking Evolution: The Revolution That’s Hiding in Plain Sight (2021) See first: RNAi 2002 to RNAi 2002 to AI 2021 (10)

RNAi 2002 to AI 2021 (8)

Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes 8/12/19 To test whether the inclusion of amino acids addresses this problem, we coupled direct techniques of cryoelectron microscopy and fluorescence microscopy Reported as:  First cells may have emerged because building blocks of proteins stabilized membranes 8/12/19 The stability of membranes is hydrogen-bond (pH) RNAi 2002 to AI 2021 (8)

RNAi 2002 to AI 2021 (7)

I found this claim in an unpublished blog post from 4/14/15 while attempting to update other posts. Most of more than 1600 are missing the focus keyphrase “microRNA” …the control of cellular and organism-wide homeostasis by the epigenetic effects that inhibit viral replication (e.g., proper nutrition and social stress inhibition), might be the best approach RNAi 2002 to AI 2021 (7)

RNAi 2002 to AI 2021 (4)

Happy New Year. Got SARS-Cov-2 or one of its synthetic mRNA vaccine-induced variants yet? SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes 12/28/21 …we unexpectedly discovered a viral miRNA-like small RNA, named CoV2-miR-O7a (for SARS-CoV-2 miRNA-like ORF7a-derived small RNA). Its abundance ranges from low to moderate as compared to host miRNAs RNAi 2002 to AI 2021 (4)

RNAi 2002 to AI 2021 (2)

For more facts that link RNAi to young earth creationism and AI to pseudoscientific nonsense, see: DNA from dirt can offer new view of ancient life 7/12/21 The new study adds to a handful of others to show the power of DNA from ancient soils. No experimental evidence of biophysically constrained energy-dependent top-down creation of RNAi 2002 to AI 2021 (2)

microRNA-mediated cures (10)

Merry Christmas 2021! Summary: microRNA-mediated cures for all virus-driven pathology have been linked from the 2002 Breakthrough of the Year: Small RNAs (12/19/02) to the 2021 Breakthrough of the year: Protein structures for all (12/16/21) via light-activated carbon fixation and biophysically constrained naturally-attenuated viral endemicity/latency in species from cyanobacteria to humans. As presciently predicted in microRNA-mediated cures (10)

microRNA-mediated cures (8)

A clear indicator of what is required to end the SARS-CoV-2 pandemic was published as: Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review) 12/20/21 The pathophysiology of coronavirus disease 2019 (COVID‑19) is mainly dependent microRNA-mediated cures (8)