RNA-mediated toxicity

RNAi 2002 to AI 2021 (10)

The 6-part series on Energy-dependent epigenetic translation to mRNA stability that ran here between 5/12/17 and 5/22/17 predictably links facts about energy-dependent microRNA-mediated chromosomal inheritance to the end of all the stupid theories that were touted by Gene Levinson in Rethinking Evolution: The Revolution That’s Hiding in Plain Sight (2021) See first: RNAi 2002 to AI 2021 (8) Light-activated microRNA biogenesis obviously links God’s energy-dependent Creation of the cell wall across kingdoms via: Biogenesis and Mechanisms of miRNA-Mediated Gene Regulation…

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RNAi 2002 to AI 2021 (4)

Happy New Year. Got SARS-Cov-2 or one of its synthetic mRNA vaccine-induced variants yet? SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes 12/28/21 …we unexpectedly discovered a viral miRNA-like small RNA, named CoV2-miR-O7a (for SARS-CoV-2 miRNA-like ORF7a-derived small RNA). Its abundance ranges from low to moderate as compared to host miRNAs and it associates with Argonaute proteins-core components of the RNA interference pathway. For a historical perspective on the role of microRNA-like small RNAs in viruses,…

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RNAi 2002 to AI 2021 (2)

For more facts that link RNAi to young earth creationism and AI to pseudoscientific nonsense, see: DNA from dirt can offer new view of ancient life 7/12/21 The new study adds to a handful of others to show the power of DNA from ancient soils. No experimental evidence of biophysically constrained energy-dependent top-down creation of soil types exists that extends the dating from Biblical Genesis beyond the past 5-10,000 years. That fact places God’s Creation of energy-as-information into the context…

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microRNA-mediated cures (10)

Merry Christmas 2021! Summary: microRNA-mediated cures for all virus-driven pathology have been linked from the 2002 Breakthrough of the Year: Small RNAs (12/19/02) to the 2021 Breakthrough of the year: Protein structures for all (12/16/21) via light-activated carbon fixation and biophysically constrained naturally-attenuated viral endemicity/latency in species from cyanobacteria to humans. As presciently predicted in Biblical Genesis, the physiology of pheromone-regulated genetic processes is required. That fact has been exemplified in at least 3 different patents, all of which attest…

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microRNA-mediated cures (5)

“Dead” nucleotides are biophysically constrained pH-dependent single nucleotide substitutions (SNPs). See first: microRNA-mediated cures (4) Remember what’s been known for decades about dead nucleotides, nucleotide substitutions that are biophysically constrained, when you read about the prevention of bioterrorism and public health fascism in Imagination and remembrance: what role should historical epidemiology play in a world bewitched by mathematical modelling of COVID-19 and other epidemics? 6/7/21 …every established respiratory pandemic of the last 130 years has caused seasonal waves of infection…

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microRNA-mediated cures (3)

See first:  microRNA-mediated cures (2) For comparison to Genetic variations creating microRNA target sites…, and Nutrient-dependent/pheromone-controlled adaptive evolution, Masatoshi Nei claimed that nucleotide substitutions, insertion/deletion, segmental gene duplication, genomic duplication, changes in gene regulatory systems, transposition of genes, horizontal gene transfer et al., were mutations. Simply put, simple-minded theorists start with the idea that everything the happens to our supercoiled DNA is a mutation and they link mutations to evolution across billions to millions of years after energy-emerged from the…

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microRNA-mediated cures (1)

See first: Naturally attenuated viral endemicity (10) All effective cancer therapies and drug therapies are energy-dependent and microRNA-mediated. Princeton team disables long-targeted gene behind spread of major cancers 11/29/21 This discovery has its roots in 2004 research in which Princeton scientists identified a gene implicated in metastatic breast cancer, called metadherin, or MTDH. Prevent obfuscation of facts that link energy-dependent changes in single nucleotide polymorphisms (SNPs) in microRNAs to all effective cancer treatments via the RBP-noncoding RNA regulation network. Read:…

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Naturally attenuated viral endemicity (10)

See: Naturally attenuated viral endemicity (9) Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life” 4/25/20 links God’s Creation of energy-as-information from Peptide synthesis at the origin of life 11/13/20 to naturally attenuated viral endemicity across kingdoms via food energy-dependent pheromone-regulated genetic processes of reproduction. See for comparison: Kinematic self-replication in reconfigurable organisms This suggests other unique and useful phenotypes can be rapidly reached from wild-type organisms without selection or genetic engineering… Conclusion: Even if the behaviors…

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Naturally attenuated viral endemicity (8)

See first: Naturally attenuated viral endemicity (7) “MicroRNA-101-3p Modulates Mitochondrial Metabolism via the Regulation of Complex II Assembly 11/19/21 …we describe a new role for miR-101-3p as a modulator of mitochondrial metabolism via its regulation of multiple mitochondrial processes, including mtDNA transcription and complex II biogenesis.” See also: Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function 11/24/21 Exposure to long wavelength light (650–900 nm) in animals improves mitochondrial function, increasing ATP production and…

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Orchestrated death: J. Michael Bailey

A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development 10/7/21 Epigenetic manipulation of the human VNTR was sufficient to switch off ZNF558 expression and thereby increase SPATA18 expression. Our data reveal the co-option of a TE-controlling KZFP to regulate a protein-coding gene and how this regulatory network is controlled between species and human individuals by a cis-acting structural variation. Presumably, the molecular mechanisms are the same in people with gender dysphoria. Reported…

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