RNA methylation

Light energy-induced base pair changes (2)

See: Light energy-induced base pair changes (1) To help others move forward via the concept of energy-dependent biophysically constrained RNA-mediated protein folding and what is known about how virus-driven energy theft is linked to all pathology, see also: Subatomic Particles, Part 1: Leptons Subatomic Particles, Part 2: Baryons, the Substance of the Cosmos Subatomic Particles, Part 3: Mesons If you are not ready to start from the de novo creation of the energy in a hydrogen atom, you may need…

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Light energy-induced base pair changes (1)

Semisynthetic organisms and synthetic biology Unintended Consequences of Expanding the Genetic Alphabet Conclusion: …phototoxicity results presented herein using a human skin cancer cell line are intended to create awareness to the scientific community of the potential unintended consequences of expanding the genetic alphabet with unnatural nucleosides like those used in this work. Reported as:  Unintended consequences of creating the world’s first semisynthetic organism Excerpt: …the artificial base pair makes living cells more susceptible to damage from low doses of sunlight and…

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The Aquatic Ape: New evidence?

The Waterside Ape BBC Radio 4 Publicity Sir David Attenborough considers whether new evidence will help a once widely ridiculed theory of human origins move towards to mainstream acceptance. In 1960, the eminent Oxford marine biologist Sir Alister Hardy proposed a revolutionary idea: that our human ancestors had not started their existence on the wide savannahs of Africa, but had become accustomed to living alongside water – swimming and diving in the shallows, collecting the abundant food, and learning to…

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From angstroms to ecosystems

How a happy moment for neuroscience is a sad moment for science Systems neuroscience is celebrating a landmark, but one that shows the way we do science is broken. Excerpt: These data are the first complete set of neural activity recordings released before publication. No papers preceded it; not even a report. Nothing. Just: here you go guys, the fruits of the joint labour of around 100 people over 4 years.” My comment: They released the information on June 13,…

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Food supplement or licensed immunostimulant?

Glucan from Food Supplement to a Licensed Drug   Excerpt: “…β-glucan possesses a significant immunostimulating activity in a wide variety of species, including earthworms, shrimp, fish, chicken, rats, rabbits, guinea pigs, sheep, pigs, cattle, and, last but not least, humans. Based on these results, it has been concluded that β-glucan represents a type of immunostimulanting molecule that is actively spanning full evolutionary spectrum. Some experiments also show that β-glucan can help even in the protection of plants. β-Glucan is therefore…

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Virus-driven downsizing of the human brain (3)

Is there anyone who is still touting neo-Darwinian pseudoscientific nonsense who understands how the transgenerational epigenetic inheritance of Zika virus damage must be linked to all energy-dependent RNA-mediated cell type differentiation or from the virus-driven degradation of messenger RNA to all pathology? Evolution 2016 Videos (Indexed) Youtube videos Posters See for comparison: Direct radiocarbon dating and genetic analyses on the purported Neanderthal mandible from the Monti Lessini (Italy) Conclusion: If materials from sites excavated long ago (e.g. Riparo Mezzena) are…

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Q and A: Energy-dependent cell type differentiation

Richard Lenski and other theorists will not discuss the amount of pseudoscientific nonsense they have included in their ridiculous claims. Rarely does anyone else attempt to unravel their claims in the context of the reports I will cite below, or in other reports that refute ridiculous neo-Darwinian theories. Recently, however, Greg Thurston made an honorable effort to learn about energy-dependent biophysically constrained cause and effect via a series of questions that could be answered with minimal jargon. Q and A…

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Biophotonics, glycobiology, quantized biodiversity (2)

From Fertilization to Adult Sexual Behavior (1996) In our section on Molecular epigenetics, we wrote: Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility…

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The end of neo-Darwinism

Rapid bacterial infection test reduces antibiotic use Excerpt: The rapid tests detect C-reactive protein (CRP), a marker of infections caused by bacteria, in patients’ blood. A low level of CRP is suggestive of viral infection and therefore antibiotic treatment is not required. My comment: The level of one protein differentiates between a viral and a bacterial infection. That fact attests to claims that one RNA-mediated amino acid substitution in a virus increases its virulence. The major antigenic changes of the…

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Biophotonics, glycobiology, quantized biodiversity

Historical perspective: From Fertilization to Adult Sexual Behavior Excerpt: Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may…

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