Variations

Codon optimality vs systemic fraud (5)

Light-Controlled Recruitable Hybridization Chain Reaction on Exosome Vehicles for Highly Sensitive MicroRNA Imaging in Living Cells 6/27/22 links more than 144,000 other publications that mention miRNAs from Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 to patented therapeutic solutions that help to protect organized genomes from the virus-driven degradation of messenger RNA. See: Results of Search in PGPUB Production Database and specifically: Nutraceuticals for the prevention, inhibition, and treatment of SARS-CoV-2 and associated COVID-19 The fact that natural selection…

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Crimes against humanity (2)

If they continue to ignore the science, the opinions of patriots will continue to be ignored. See for comparison, the science of virus-driven disease prevention. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer (2015) and Expression change in Angiopoietin-1 underlies change in relative brain size in fish (2015) link miRNAs in exosomes to viral endemicity via Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3 (2015) and the honeybee model of Nutrient-dependent/pheromone-controlled adaptive evolution (2013) In…

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Crimes against humanity (1)

From Michigan State University Ask the expert: What is Juneteenth? Historical Perspective: See: “Apology to People of Color for APA’s Role in Promoting, Perpetuating, and Failing to Challenge Racism, Racial Discrimination, and Human Hierarchy in U.S.” October 29, 2021 When will this historic apology be celebrated? Did you even know about it? Michigan State’s Richard Lenski still promotes the moronic theory that racial differences evolved from nutrient-dependent pheromone-regulated genetic processes of reproduction in E. coli. See: Experimental Test of the…

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Codon optimality vs systemic fraud (4)

A good model predicts. See: From Fertilization to Adult Sexual Behavior (1996). In our section on molecular epigenetics we predicted that A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins 6/16/22 would be linked to food energy and pheromone-regulated genetic processes of reproduction across kingdoms. On 6/23/22, that fact was placed back into the context of stupid theories. See: Abracadabra, One Becomes Two: The Importance of Context in Viral −1 Programmed Ribosomal Frameshifting  Yeast and potentially mammalian cells,…

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Polymathy changes society (1)

Is X-FILES relevant now… Did X-FILES predict the future? 6/9/22 (video) Science fiction author Greg Bear linked gene editing technology to the laboratory-based creation of a novel virus in his 2006 review published as “Quantico.” His claims about the existential threat were turned into a comedy routine by Jon Stewart. 6/1/07 (video) Former President Trump linked God’s Creation of sunlight and humidity to healthy longevity via KB Whaley’s polymathy when he claimed, albeit indirectly, that pH-dependent microRNA-mediated protein folding chemistry…

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Codon optimality vs systemic fraud (3)

A system of fraud exists that fails to link natural selection for energy-dependent codon optimality to The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents 5/17/22 This article belongs to the Special Issue Molecular Effects of Phytochemicals on Cholesterol Metabolism Genes Collectively, everything known to intelligent serious scientists about cell type differentiation across kingdoms can be linked from An Expanded Landscape of Unusually Short RNAs in 11 Samples…

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Codon optimality vs systemic fraud (1)

Two summaries of neo-Darwinian evolutionary theory: Amino acid composition of proteins varies substantially between taxa and, thus, can evolve. …yeast receptors trigger activation of heterotrimeric G proteins just as mammalian receptors do, this conserved signaling pathway must have been present in the common ancestor of yeast and humans. Unless you are a biologically uninformed theorist, see first Epistemic corruption (10) Watch for my next 10-part series on Codon optimality vs systemic fraud. I will link it to the fraudulent representations…

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Epistemic corruption (10)

Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly 5/26/22 Full functional evaluation of the recombinant key enzymes in vivo and in vitro, individually and in concert, provided in-depth mechanistic insights into a streamlined C–C bond-forming cascade that involves installation of compatible reactivity at seemingly unreactive Cα positions of amino acid precursors. Our work extends the biosynthetic and biocatalytic toolbox for γ-butyrolactone formation, provides a general paradigm for furanolide biosynthesis and sets the stage for their targeted discovery, biosynthetic…

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Epistemic corruption (8)

What don’t you believe about these facts from 1910? I posted this video to Facebook one year ago, after a trip across the United States, which I chronicled in a series of other videos. Since then, “Cellulose” has linked fixation of amino acid substitutions to construction of the cell wall and microRNA-mediated protein folding chemistry via microRNA-mediated stem cell creation and healthy longevity across kingdoms. For examples of how energy-dependent ecological adaptations eliminate stupid theories about mutation-driven evolution, which link…

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MicroRNA-mediated existential threats (8)

Summary: Natural processes link light-activated microRNA biogenesis to pH-dependent prevention of viral infections. The natural processes are energy-dependent and biophysically constrained by the pheromone-regulated genetic processes of reproduction across kingdoms from microbes to humans. Follow me @microRNApro on Twitter if you want to help others prevent virus-driven existential threats to humanity. See also: MicroRNA.pro, http://Autophagy.pro & continue to follow me on http://RNA-mediated.com as I link God’s Creation of subatomic particles from pH-dependent peptide synthesis to sympatric speciation and healthy ecosystems…

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