Charles Darwin wrote:

  1. IF under changing conditions of life…
  2. …variability is generally related to the conditions of life…
  3. …we cannot tell how much to attribute to the accumulative action of natural selection, and how much to the definite action of the conditions of life.
  4. …during the process of modification, each has become adapted to the conditions of life…

Charles Darwin placed his energy-dependent “conditions of life” first. He knew that natural selection could not occur outside the context of the conditions of life, which are nutrient energy-dependent and pheromone-controlled via the physiology of reproduction in species from microbes to humans.

For information on how ecological variation is linked to ecological adaptation in the context of what is known about Darwin’s and God’s “conditions of life” see:

FEB 23, 2017 12:00 PM PST
Speaker: James Prudent, PhD
Specifically, this talk will focus on proteins that interact with the human Na,K-ATPase (NKA). An active plasma membrane ion pump, the NKA is required for life. Without it, the cell cannot maintain a proper ion potential and the cells dies by a natural death process known as necrosis.


The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See also:

1) ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons

2) Evolutionary drivers of thermoadaptation in enzyme catalysis

3) Endogenous RNAi Pathways Are Required in Neurons for Dauer Formation in Caenorhabditis elegans

4) Nutrient-dependent/pheromone-controlled adaptive evolution: a model

5) Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition

6) Metabolic theory predicts whole-ecosystem properties

7) The phylogenetic utility and functional constraint of microRNA flanking sequences

8) Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression

9) MicroRNA analysis in mouse neuro-2a cells after pseudorabies virus infection

10) microRNA-binding proteins: specificity and function

11) RNA in extracellular vesicles

12) Structural diversity of supercoiled DNA

13) Communication between viruses guides lysis–lysogeny decisions

14) The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters

15) Prevalence and architecture of de novo mutations in developmental disorders

16) All about the base

17) Chemists know

18) Dynamic control of chirality and self-assembly of double-stranded helicates with light

19) The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes

20) RNA-Guided Human Genome Engineering

21) What is Life?

22) Arginine 66 Controls Dark-State Formation in Green-to-Red Photoconvertible Fluorescent Proteins

23) Evolution of gonadotropin-releasing hormone (GnRH) structure and its receptor

24) A Big Bang in spliceosome structural biology

See also:

Achieving Reversible H2/H+ Interconversion at Room Temperature with Enzyme-Inspired Molecular Complexes: A Mechanistic Study

Activity-dependent spatially localized miRNA maturation in neuronal dendrites

The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression

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