“…since epigenetic alterations can promote genetic stability and promote genetic mutations, as previously described32,33, the integration with genetic mutations in the future with the transgenerational germline epigenetics is needed. Future research will need to include the histone core and DHRs in the elucidation of epigenetic transgenerational inheritance mechanisms.”
The epigenetic alterations that promote genetic stability are energy-dependent and RNA-mediated. The virus-driven theft of quantized energy has been linked from mutations to all pathology in more than 71,000 published works.
See for a historical perspective: Energy as information and constrained endogenous RNA interference (audio/visual aid)
Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA.
Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.