Summary: Epigenetic mechanisms did not evolve. DNA methylation is food energy-dependent and RNA-directed. Phenotypes are not fixed by genetics. The food energy-dependent RNA-directed DNA methylation of all organized genomes is biophysically constrained by the metabolism of food to pheromones, which control the physiology of food-dependent reproduction.
On the day after he posted content on the refutation of Karl Popper’s nonsense and the pseudoscientific nonsense touted in every aspect of neo-Darwinian theory, antagonist Jay Feierman posted this to the Human Ethology group:
DNA methylation is involved in gene regulation, silencing of transposons, imprinting, polyphenism, and consolidation of speciation. It may even act as a driver of evolution via stochastic developmental and environmentally induced epigenotype diversification, transgenerational inheritance of epigenetic patterns with phenotypic effects, and differential selection and genetic fixation of these phenotypes.
Epigenetic mechanisms did not evolve. DNA methylation is food energy-dependent and RNA-directed. Phenotypes are not fixed by genetics. The food energy-dependent RNA-directed DNA methylation of all organized genomes is biophysically constrained by the metabolism of food to pheromones, which control the physiology of food-dependent reproduction. Food and pheromones typically biophysically constrain all virus-driven pathology. That allows ecological variation to be linked to ecological adaptation via transgenerational epigenetic inheritance in species from microbes to humans.
See: RNA-directed DNA methylation: an epigenetic pathway of increasing complexity
Simply put, increasing complexity does not automagically evolve. It is biophysically constrained by what organisms eat (i.e., food energy.)See also: RNA-mediated epigenetic regulation of gene expression
Jay Feierman‘s efforts to prevent the dissemination of accurate information about biophysically constrained biologically-based food energy-dependent RNA-mediated cause and effect have led to the unnecessary suffering and premature death of millions during the past 2 decades since I personally presented to him (at a conference) the model that has since been linked to all healthy longevity in all species. (His only question was “What about birds?”)
Rarely have I seen anyone display the lack of regard for biodiversity and for human life that Jay Feierman has included in his examples of “human idiocy.” His posts about the “Evolution of Epigenetic Mechanisms” and posts about the evolution of anything else should long ago have been the “last straw” for all serious scientists. And yet, it seems that no one can stop people like Jay Feierman.
For comparison, the late Charles Manson supposedly claimed: “I am the devil.” If true, in my opinion, another devil is alive and well and his name is Jay Feierman.
Search this domain for: RNA-directed DNA methylation or for RNA-mediated DNA methylation to find hundreds of blog posts that appear to attest to the devilish treachery of people like Jay R. Feierman. If you find one blog post that does not attest to his human idiocy and his treachery, please let me know. I may owe him an apology.
See also, this Google search: RNA mediated, which attests to the facts about why this is currently the top-ranked domain.
Feierman’s other posts to the Human Ethology Group on 11/20/17 include:
Formal Epistemology and Cartesian Skepticism: In Defense of Belief in the Natural World
Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?
Give one species the task to come up with a theory that spans them all: what good can come out of that?
A soft selective sweep during rapid evolution of gentle behaviour in an Africanized honeybee
Variability in Fitness Effects Can Preclude Selection of the Fittest
Throughout the animal kingdom, individual variation in reproductive success is commonly observed, even under similar environmental conditions. However, the mechanisms behind such differences remain unclear.
The mechanisms are energy-dependent and RNA-mediated. Feierman’s “bird-brained” nonsense takes us back to this example of food energy-dependent pheromone-controlled transgenerational epigenetic inheritance of morphology and behavior in a bird species, see: Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes (2014)
For a direct attack on my accurate representations, see: One crank dies, another rises to take his place
In the context of A third of Americans don’t believe in evolution, I wrote:
Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction.
These facts do not refute evolution; they simply refute the ridiculous theory of mutation-initiated natural selection that most people here were taught to believe is the theory of evolution.
That theory is far too ridiculous to be anything but a joke in the context of biological-based increasing organismal complexity. But here, we have lots of jokers, don’t we? The proof of ecological variation that appears to refute the theory of evolution, which actually refutes itself, is that ecological adaptations occur too fast for mutations to compete with them as a source of anything but diseases and disorders.
For comparison, see the comment by Jay R. Feierman on my model:
7/25/13 Jay R. Feierman:
Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.
My model was published as a refutation of neo-Darwinian evolution. Nutrient-dependent/pheromone-controlled adaptive evolution: a model
No one has ever attempted to refute Darwinian evolution. Darwin reasserted the claim that others must start with his “conditions of life.” They are nutrient-dependent and pheromone-controlled. Anyone who has ever started with natural selection is as foolish as Darwin knew they would be.
In “Advancing Techniques Reveal the Brain’s Impressive Diversity,” Rusty Gage and two of his postdocs, Sara Linker and Tracy Bedrosian, describe nonvisual methods for delving ever deeper into neurons—analyzing not just what you see, but what you get by performing genome sequencing and transcriptional, posttranscriptional, posttranslational, and epigenetic analyses on single cells.
The virus-driven degradation of messenger RNA has been linked to the destruction of all food energy-dependent pheromone-controlled biophysically constrained ecosystems in species from microbes to humans.
…revealed a surprising relationship between dementia and decreased quality of RNA—a key player in gene expression—in the more aged brain.
Obviously, something has gone horribly wrong. Serious scientists can now simply recommend that everyone older than 10 play the game Cytosis.
A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!
Anyone older than 10 can then dismiss the claims of people like Rusty Gage about ecology and simply link what organisms eat from ecological variation to ecological adaptation via the physiology of pheromone-controlled reproduction, or link the virus-driven degradation of messenger RNA from mutations to all pathology.