Age at onset of puberty is affected by a combination of genetic, nutritional, and other environmental factors and that timing, in turn, is associated with risk of cancer later in life.
Who will be next to link energy-dependent changes in the microRNA/messenger RNA balance from nutritional epigenetics to other environmental factors and stress-linked pathology in all organized genomes?
They report that the strongest age at menarche (AAM) signal encodes a key repressor of energy-dependent microRNA biogenesis, which links methylation to limits on cell pluripotency.
Other significant genome wide signals were mapped to lysine-specific demethylase genes or to Mendelian pubertal disorder genes such as GNRH1 (178) and KAL1 (378). KAL1 and GnRH link olfaction and pheromones from fertilization to adult sexual behavior.
Stop pretending it takes a team of hundreds of people to determine that all biodiversity on Earth is nutrient energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction. All serious scientists know that feedback loops link chirality and autophagy from changes in the morphological and behavioral phenotypes of microbes to mammals during their life history transitions.