See Energy-dependent chirality

2013 MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination

See also E. Ben-Jacob

Ben-Jacob et al., have linked everything currently known about natural information processing from natural selection for energy-dependent codon optimality to healthy longevity and from virus-driven energy theft to mutations that cause cancer.

See for comparison: LH Tsai

Tsai laboratory

Our primary goal is to elucidate the mechanisms underlying neurological disorders affecting learning & memory. The major research areas include age disorders, autism, and Alzheimer’s disease.

2012 MicroRNAs in learning, memory, and neurological diseases

Recent advances in methods of next-generation sequencing, such as RNA-seq, offer the means to quantitatively evaluate the functions of miRNAs in a genome-wide manner in large cohorts of samples. These new technologies have already yielded valuable information and are expanding our understanding of miRNA-based mechanisms in higher-order brain processing, including learning and memory and cognition, as well as in neuropsychiatric disorders.

2015 Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

The exposure to a new sensory experience, for instance, profoundly alters the morphology and connectivity of neural circuits, and these changes are thought to be instrumental in the formation of long-lasting memories and adaptive responses (Goelet et al., 1986).

They linked ecological variation to experience-dependent changes in the connectome and ecological adaptations.

2016 Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

They linked the ecological adaptation to social behavior.

Reported as: Researchers identify genome-modifying enzyme linked to Rett Syndrome

To understand how the HDAC3 protein regulates the genes, the researchers then analysed them further. In particular, they hoped to identify any motifs, or patterns of DNA sequence, to which regulatory proteins, known as transcription factors, could bind. Transcription factors are proteins that control which genes are turned on or off within the genome.

They linked ecological variation to gene regulation via energy-dependent transcription

2016 Gamma frequency entrainment attenuates amyloid load and modifies microglia

Abstract conclusion:

Our findings uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer’s-disease-associated pathology.

They linked light-induced changes in gamma oscillations (20-50 Hz) to pathology via levels of amyloid-beta (Abeta)1-40 and Abeta 1-42 isoforms in the context of energy-dependent changes in the onset of plaque formation and cognitive decline in the mouse model of Alzheimer’s disease.

isoform: any of two or more functionally similar proteins that have a similar but not an identical amino acid sequence.

Tsai et al., have linked everything currently known about natural information processing from natural selection for energy-dependent codon optimality to RNA-mediated amino acid substitutions and healthy longevity and from virus-driven energy theft to mutations that cause neurodegenerative diseases. They place what is known about amino acid substitutions into the context of isoforms.

See also: 2017 In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory

Everything known about natural selection for energy-dependent codon optimality and healthy longevity for comparison to virus-driven energy theft and the mutations linked to all pathology is placed into this context:

“… neuronal activity induces relocalization of gene loci to ‘transcription factories’, and specific enhancer–promoter looping contacts allow for precise transcriptional regulation.

Learning and memory appear to depend on specific enhancer–promoter looping instead of energy-dependent changes that link microRNAs from amino acid substitutions to healthy longevity and virus-driven energy theft to cancer via the works of Eshel Ben-Jacob et al.

Enhancer–promoter looping interactions are an important event in transcriptional initiation, but looping is not always sufficient to drive expression per se. This is exemplified by the finding that many looping contacts are established prior to gene activation [66].

Claims about enhancer–promoter looping interactions obfuscate facts about energy-dependent transcription, which is established in the context of energy-dependent changes in the microRNA/messenger RNA balance. The works of LH Tsai et al., go a long way towards obfuscating the facts serious scientists have learned form the works of the late Eshel Ben-Jacob et al.

See also: Language and Communication as Universal Requirements for Life (link opens pdf)

If stem-loop consortia build complex consortia, they initiate social interactions not present in a pure chemical world, that is, biological selection emerges. This designates the crucial step from inanimate world to life (Figure 16.8).

No matter how much obfuscation of facts about energy-dependent chromatin remodeling is introduced via use of different terms, such as chromatin topology, stem-loop and enhancer–promoter looping, the word play can always be viewed in the context of funding attempts that are the primary concern of politicized science.

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