Excerpt: Summaries of mutation categories: The summaries attest to the fact that human interethnic biodiversity can be linked to all biodiversity via the food energy-dependent creation of enzymes and the pheromone-controlled physiology of reproduction, which link autophagy to biophysically constrained viral latency.
…the findings are “not a show stopper, but the field needs to know about this…
Investors are stopping the Zhang-Church-Doudna show. Some were prepared to invest in energy-dependent RNA interference, which biophysically constrains viral latency.The way forward was predicted in 1999 with publication of RNA-triggered gene silencing and revisited with publication of Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy
RNAi based drugs have now advanced steps closer towards clinical trials. The powerful in-vivo RNAi machinery and its delicate factors apprehend that RNAi-dependent therapies might create a billion dollar business against the pathogenic organisms and disease for which treatment options are currently restricted conventionally.
Food energy-dependent microRNA-mediated amino acid substitutions biophysically constrain viral latency and all serious scientists know that.
The “…miRNA-mediated regulation of enzymes and transporters affecting drug metabolism…” links the National Microbiome Initiative to the Precision Medicine Initiative and to all healthy longevity or to all virus-driven pathology in all living genera via differences in energy as information.
The identified variant affected a fully conserved amino acid that is part of the catalytic site of the enzyme.
Now that the cause of the symptoms is known [i.e., the loss of the conserved amino acid substitution], it is possible to think about an enzyme replacement therapy for the patients [whose symptoms are obviously caused by the virus-driven degradation of messenger RNA, which links the missense variation and all other mutations to all pathology via the loss of fixed amino acid substitutions in all living genera].
The enzyme replacement therapy would not be required in the context of what is known to all serious scientists about energy-dependent RNA-mediated cell type differentiation in all living genera. See for examples of what is known about the conserved amino acid substitution on page 19 of this sample report. The creation of CYP enzymes clearly links the food that people eat to healthy longevity. Alternatively, the virus-driven theft of quantized energy can be linked to the virus-driven degradation of messenger RNA and all pathology, which traditional medicine has attempted to treat with pharmaceuticals and/or surgery.
See for details of how biophysically constrained viral latency is linked from the energy-dependent creation of microRNAs to all biodiversity in the context of a model that links atoms to ecosystems and refutes all theoretical pseudoscientific nonsense.
…the explanatory power of a model of ecological variation and biophysically constrained nutrient-dependent pheromone-controlled ecological adaptations became clear with companion papers published in 2013. See for review .
The companion papers [162-163] told a new short story of ecological adaptations. In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China.
30) Kohl, J. V., Nutrient–dependent / pheromone–controlled adaptive evolution: a model. Socioaffective Neuroscience & Psychology 2013, 3. doi: 10.3402/snp.v3i0.20553
162) Kamberov, Yana G.; Wang, S.; Tan, J.; Gerbault, P.; Wark, A.; Tan, L.; Yang, Y.; Li, S.; Tang, K.; Chen, H., et al., Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell 2013, 152 (4), 691-702. doi: 10.1016/j.cell.2013.01.016
163 Grossman, Sharon R.; Andersen, Kristian G.; Shlyakhter, I.; Tabrizi, S.; Winnicki, S.; Yen, A.; Park, Daniel J.; Griesemer, D.; Karlsson, Elinor K.; Wong, Sunny H., et al., Identifying Recent Adaptations in Large-Scale Genomic Data. Cell 2013, 152 (4), 703-713. doi: 10.1016/j.cell.2013.01.035
The naturally selected food energy-dependent EDAR variant and two amino acid substitutions have since been linked to human interethnic biodiversity in the context of other energy-dependent RNA-mediated fixation of all amino acids in all cell types of all individuals of all living genera.
See: Brief report: Geographic variation in EGFR mutation frequency in lung adenocarcinoma may be explained by interethnic genetic variation The full article can be downloaded from here:
G180A (aka ABCC11, Gly180Ala) and V370A (aka 1540T/C, 370A or Val370Ala) are established biomarkers of East Asian ancestry. Taken together, the two amino acid substitutions clearly linked rs17822931 and rs3827760 respectively to other food energy-dependent changes in base pairs via the physiology of pheromone-controlled reproduction and biophysically constrained interethnic biodiversity in a human population.
Val370Ala is a single nucleotide polynmorphism (SNP) in the ectodysplasin A receptor (EDAR) gene on chromosome 2. The adaptive variant links food energy-dependent changes in immunity from the mouse model to human biodiversity via autophagy, the innate antiphage defense mechanism.
Eighteen years ago, Gly180Ala was linked from the creation of ATP to the creation of RNA and all food energy-dependent hemoglobin variants via the publication of Rotation of F(1)-ATPase and the hinge residues of the beta subunit
The mean work done by a 120 degrees step was approximately 80 pN nm, a value close to the free energy liberated by hydrolysis of one ATP molecule, implying nearly 100% efficiency of energy conversion. The torque is probably generated by the beta subunit, which undergoes large opening-closing domain motion upon binding of AT(D)P. We identified three hinge residues, betaHis179, betaGly180 and betaGly181, whose peptide bond dihedral angles are drastically changed during domain motion. Simultaneous substitution of these residues with alanine resulted in nearly complete loss (99%) of ATPase activity.
Simply put, the Val370Ala and Gly180Ala substitutions exemplify how the anti-entropic virucidal energy of sunlight is biophysically constrained by the substitution of achiral glycine in position 6 of the gonadotropin releasing hormone (GnRH) decapeptide and the food energy-dependent pheromone-controlled fixation of other amino acid substitution that differentiate all cell types in all living genera. In humans.
For example, more than 1700 hemoglobin variants have bee linked to interethnic bidiversity and to primate species biodiversity via the nutrient energy-dependent pheromone-controlled fixation of one or more amino acid substitutions in the organized genomes of humans, chimpanzees, and gorillas.
For example, the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.
Single nucleotide substitutions or indels [INsertions/DELetionS] can lead to several hemoglobin variants owing to amino acid replacements, while molecular defects in either regulatory or coding regions of the human HBA2, HBA1, HBB or HBD genes can minimally or drastically reduce their expression, leading to α-, β- or δ-thalassemia, respectively.
The nucleotide substitutions are food energy-dependent. The virus-driven theft of quantized energy causes the deletions. Ecological variation links the ability to find food to ecological adaptations only in the context of the pheromone-controlled physiology of reproduction, which biophysically constrains viral latency during the transgenerational epigenetic inheritance of healthy morphological and behavioral phenotypes.
See also: HbVar: A Database of Human Hemoglobin Variants and Thalassemias: Summaries of mutation categories
The summaries attest to the fact that food energy-dependent human interethnic biodiversity can be linked to all biodiversity via the creation of enzymes and the pheromone-controlled physiology of reproduction, which link autophagy to biophysically constrained viral latency.
Re: Monetization of these facts: First, consider short-selling the stocks of companies that have built their capitalization on ridiculous claims that link mutations to evolution. Those claims disappeared with release of the cell biology game “Cytosis.”
Next, buy or lease one — or all three — of the following domains from the owner / founder of the only domains that have continued to disseminate the facts about pheromone constrained viral latency, since 1995 (which is when I founded Pheromones.com). Then RNA-mediated.com. Then Autophagy.pro.
If you have any doubts about what your future holds, see: