Summary: Wen Zhou’s group has linked the creation of anti-entropic virucidal light from the quantized energy-dependent creation of microRNAs to the food energy-dependent neuroendocrine origins of human behavior via the pheromone-controlled physiology of reproduction and fixation of RNA-mediated amino acid substitutions in species from microbes to humans. Simply put, she has linked quantum physics to quantum souls via what is known about biophysically constrained viral latency in the context of the cell biology game Cytosis and the future of biology.

Perception of social interaction compresses subjective duration in an oxytocin-dependent manner May 22, 2018

These findings indicate that perceived time, rather than being a faithful representation of physical time, is highly idiosyncratic and ingrained with one’s personality trait. Moreover, they suggest that oxytocin is involved in mediating time perception of social interaction, further supporting the role of oxytocin in human social cognition.

Reported as: Oxytocin mediates subjective duration of social interactions May 23, 2018

These findings highlight the idiosyncrasy of subjective time and represent an initial effort to trace it back to personality factors and their neuroendocrine origins.

I reported this yesterday and today in the context of Olfaction Warps Visual Time Perception. I failed to suspect that biologically uninformed science idiots would report everything known about the links from quantum physics to quantum souls as if they were mediated by the hormone oxytocin.

Wen Zhou’s group has linked the creation of anti-entropic virucidal light from the quantized energy-dependent creation of microRNAs to the food energy-dependent neuroendocrine origins of human behavior via the pheromone-controlled physiology of reproduction and fixation of RNA-mediated amino acid substitutions in species from microbes to humans. Simply put, she has linked quantum physics to quantum souls via what is known about biophysically constrained viral latency in the context of the cell biology game Cytosis and the future of biology.

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

See for instance: Website of Wen Zhou

We might fairly gauge the future of biological science, centuries ahead, by estimating the time it will take to reach a complete, comprehensive understanding of odor. It may now seem to be a profound enough problem to dominate all the life sciences, but it contains, piece by piece, all the mysteries.
— Lewis Thomas (1913-1993)

This quote also appears on page 24 of The Scent of Eros: Mysteries of Odor in Human Sexuality (1995) and as the concluding paragraph on the last page of the “Epilogue” of the updated edition (2002).

See also: Publications by Wen Zhou et al. (2008-2018)

See also:

Epigenetic inheritance of spatiotemporal regulation | RNA-Mediated

Epigenetic inheritance of spatiotemporal regulation (2) | RNA-Mediated

The Social Brain of Autism | RNA-Mediated

The Future of Biological Science (Biology) in the centuries to come requires others to examine what is known to all serious scientists about the levels of biological organization. All levels must be linked from energy-dependent fixation of RNA-mediated amino acid substitutions to the stability of organized genomes in all living genera.

For example, the EDAR V370A (Val370Ala) amino acid substitution has been linked from the stability of organized genomes in human populations from China and North America.

See: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

The historical record of positive selection for quantized energy-dependent codon optimality in the context of RNA-mediated DNA repair extends across ~6000 years, not 20,000 y, of mate selection for the epigenetic effects of food odors and pheromones on biophysically constrained viral latency.

See: Past 5,000 years prolific for changes to human genome (2012)

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

Most harmful variants were biophysically constrained. Pseudoscientists and other theorists who continue to tout their ridiculous theories about mutations and evolution are being rounded up for quick exits from academia. Failed exits invite more ridicule from serious scientists whose works are cited in the context of stress-linked pathology.

See:  Critical Issues in BDNF Val66Met Genetic Studies of Neuropsychiatric Disorders

Epigenetic studies have suggested that histone modifications, DNA methylation, and hydroxymethylation are possible mediators linking individual response to environmental factors and brain diseases (McEwen et al., 2015).

McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., et al. (2015). Mechanisms of stress in the brain. Nat. Neurosci. 18, 1353–1363.

Also cited: Bath, K. G., Chuang, J., Spencer-Segal, J. L., Amso, D., Altemus, M., Mcewen, B. S., et al. (2012a). Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice. Biol. Psychiatry 72, 499–504.

See also: Redefining neuroendocrinology: Epigenetics of brain-body communication over the life course (2017)

This article is both an account of an emerging field elucidating brain-body interactions at multiple levels, from molecules to social organization, as well as a personal account of my laboratory’s role and, most importantly, the roles of trainees and colleagues, along with my involvement in interdisciplinary groups working on this topic.

McEwen’s role and his involvement with interdisciplinary groups led me to publish a series of monographs and co-authored reviews after book publication in 1995.  The most recent review is:

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems

This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experiencedependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity. Species-specific pheromones link quorum-sensing in microbes from chemical ecology to the physiology of reproduction. The reciprocal relationships of species-typical nutrientdependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection for codon optimality links nutritional epigenetics to the behaviors that enable ecological adaptations. All biodiversity is an ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. Simply put, olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.

Every aspect of McEwen’s works, which collectively link molecules to social organization has been validated by experimental evidence that links energy-dependent changes in base pairs to RNA-mediated fixation of amino acid substitutions, DNA repair, and cell type differentiation as predicted in the molecular epigenetics section of this 1996 Hormones and Behavior review.

From Fertilization to Adult Sexual Behavior

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

Facts about the quantized energy-dependent creation of microRNAs (formerly known as pre-mRNAs) can be linked from the creation of enyzmes to food energy-dependent pheromone-controlled viral latency in all living genera. See for example: The tipping point (revisited): 73,000 publications

 

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